| Allele Name | transgene insertion 1, Julie K Andersen |
| Allele Type | Transgenic (Reporter, Inducible, Inserted expressed sequence, Humanized sequence, Transactivator) |
| Allele Synonym(s) | |
| Gene Symbol and Name | Tg(Gfap-rtTA,tetO-MAOB,-lacZ)1Jkan, transgene insertion 1, Julie K Andersen |
| Gene Synonym(s) | |
| Promoter | tetO, tet operator, |
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| Promoter | Gfap, glial fibrillary acidic protein, mouse, laboratory |
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| Expressed Gene | MAOB, monoamine oxidase B, human |
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| Expressed Gene | lacZ, beta-galactosidase, E. coli |
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| Expressed Gene | rtTA, reverse tetracycline-controlled transactivator, E. coli |
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| Strain of Origin | C57BL/6 |
| Chromosome | UN |
| Molecular Note | This transgene consists of 2 co-injected constructs. One encodes for a reverse tetracycline responsive transactivator with expression driven by a murine Gfap promoter. The second has a bidirectional tetracycline responsive promoter that drives expression of a lacZ reporter and a human MOAB cDNA. Several founders were generated and the line with the highest level of expression was used for analyses. Line 1 was generated. |
| Mutations Made By | Julie Andersen, Buck Institute for Age Research |
