Gfra1 (glial cell line derived neurotrophic factor family receptor alpha 1) is expressed by limb-innervating motor neurons. These transgenic mice express a FLAG-tagged Gfra1 under the control of a Mnx1 (motor neuron and pancreas homeobox 1; also called Hb9) motor neuron-specific promoter fragment. 

These mice show defects in hindlimb innervation. Significant thinning of the peroneal nerve indicates a reduced contribution of LMCL (lateral division of the lateral motor column) axons to the dorsal branch. Additionally, these LMCL axons misproject into the ventral hindlimb of embryos. Other motor neuron pathways including the ventral branch of the hindlimb and dorsal ramus directed to axial musculature are unaffected in embryos at E10.5-13.5. Innervation of the cutaneous maximus and latissimus dorsi muscles by brachial motor neurons that depend on GDNF (glial cell line derived neurotrophic factor) is normal.

These transgenic mice express a FLAG-tagged Gfra1 under the control of a Mnx1 (motor neuron and pancreas homeobox 1; also called Hb9) motor neuron-specific promoter fragment. Mice show defects in hindlimb innervation.

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