Females heterozygous for the X-linked hair loss mutation have patches of fur missing from the coat and this phenotype gets a little worse with age. Hemizygous males are almost bald and homozygous females are almost as bald as hemizygous males. All three genotypes breed and live a normal lifespan.
This semi-dominant mutation arose spontaneously in a mutant subline of MRL/MpJ-Faslpr that had been outcrossed to B6C3F1. It was backcrossed to C57BL/6J for twelve backcross generations then maintained by sibling intercrossing. Sperm was cryopreserved from hemizygous males at generation N12F5.
|Allele Name||X-linked hair loss|
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||Xlhl, X-linked hair loss|
|Strain of Origin||STOCK Hrhr-3J/J|
|Molecular Note||This mutation arose spontaneously and has been mapped to the X Chromosome.|