The mouse Serpinb3a gene is similar to the human SERPINB4 and SERPINB3 genes, which have been associated with allergic reactions and asthma. Mouse Serpinb3a inhibits both serine and cysteine proteinases. These mice carry a null targeted mutation of Serpinb3a; exon 8 is disrupted. No gene product (mRNA) is detected by RT-PCR analysis of homozygotes. Serpinb3a-deficient mice are less sensitive to house dust mite-induced airway hyper-responsiveness, with reduced goblet cell hyperplasia and mucus production when compared to wildtype controls. IL13-induced airway hyper-responsiveness is reduced in homozygotes, with a reduced number of inflammatory cells in the bronchoalveolar lavage fluid. Mice that are homozygous for the targeted mutation are viable and fertile.

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A NEO cassette replaces exon 8 of the Serpinb3a gene in these mice resulting in a reduced sensitivity to certain allergens.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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