Mice heterozygous for the dominant tail short 2 Jackson mutation have kinked, shortened tails that range from one quarter to three quarters the length of a normal tail. The number of kinks also varies from animal to animal. Approximately 50% of offspring from crosses between heterozygotes and C57BL/6J have the mutation, indicating full penetrance.
This spontaneous mutation arose in the strain B6.Cg-Rag1tm1Mom Fcgrttm1Dcr Tg(FCGRT)276Dcr/Dcr in the laboratory of Dr. Derry Roopenian. This dominant mutation was maintained briefly by sibling intercrossing heterozygotes with wild-type littermates and was subsequently backcrossed to C57BL/6J, reaching N4 in 2012. Through this backcrossing the targeted mutations and transgene were bred out of this mutant subline.
|Allele Name||dominant tail short 2 Jackson|
|Allele Type||Spontaneous (Not Specified)|
|Gene Symbol and Name||Rpl31, ribosomal protein L31|
|Strain of Origin||B6.Cg-Rag1tm1Mom Fcgrttm1Dcr Tg(CAG-FCGRT)276Dcr/DcrJ|
|Molecular Note||This is a spontaneous deletion of AAAT / AATA / ATAA / TAAA from the AAATAAA sequence at position 39,371,346-352 (GRCm38) in the 3' UTR.|
When using the B6.Cg-Rpl31Dts-2J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #017686 in your Materials and Methods section.