Mice heterozygous for the dominant spontaneous mutation elliptic have a vestibular defect that causes circling, but no hearing deficit at three months of age.
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous (Not Specified) | Ept | elliptic |
Mice heterozygous for the elliptic mutation display a moderate circling phenotype indicative of a vestibular defect. Consistent with this, they have difficulty orienting in water. Despite the vestibular defect, no hearing deficit was found in heterozygotes assessed by ABR at 1, 2, or 3 months of age. Homozygotes on a mixed B6;D2 background are viable and fertile and also display the same circling phenotype. This dominant heritable phenotype has incomplete penetrance, generating approximately 30% mutants from C57BL/6J x heterozygote crosses. This mutation has been mapped to an interval of Chromosome 16 between D16Mit138 and D16Mit140.
The dominant mutation elliptic arose spontaneously in the C57BL/6J strain and was maintained coisogenic on this background. Sperm was cryopreserved from homozygous males at generation N16F4.
Allele Name | elliptic |
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Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | Ept, elliptic |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 16 |
Molecular Note | This spontaneous heritable phenotype has been mapped to an interval between D16Mit138 and D16Mit140 |
When using the elliptic mouse strain in a publication, please cite the originating article(s) and include JAX stock #017556 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Ept |
Frozen Mouse Embryo | C57BL/6J-Ept/KjnJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Ept/KjnJ Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | C57BL/6J-Ept/KjnJ Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | C57BL/6J-Ept/KjnJ Frozen Embryo | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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