Mice heterozygous for the elliptic mutation display a moderate circling phenotype indicative of a vestibular defect. Consistent with this, they have difficulty orienting in water. Despite the vestibular defect, no hearing deficit was found in heterozygotes assessed by ABR at 1, 2, or 3 months of age. Homozygotes on a mixed B6;D2 background are viable and fertile and also display the same circling phenotype. This dominant heritable phenotype has incomplete penetrance, generating approximately 30% mutants from C57BL/6J x heterozygote crosses. This mutation has been mapped to an interval of Chromosome 16 between <i>D16Mit138</i> and <i>D16Mit140</i>.

Mice heterozygous for the dominant spontaneous mutation elliptic have a vestibular defect that causes circling, but no hearing deficit at three months of age.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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