Mice hemizygous for the pLD53.SC2-mCherry transgene are viable and fertile with mCherry expression directed by the Tenascin C (Tnc) promoter/enhancer regions within the BAC transgene. TNC is an extracellular matrix glycoprotein expressed in the developing embryo, and during conditions such as wound healing, inflammation and neoplasia. These mice express mCherry protein in growing and developing tissues of embryo and adults. Specifically, at E10.5 mCherry expression is high in pericardium and by E12.5 expression is detected in the developing craniofacial structures and developing limbs. At E17.5 expression is localized within cartilage. During the first 2 weeks of life, expression is restricted to tendons, ligaments, as well as periosteal and articular surfaces of the bone.

These pLD53.SC2-mCherry express mCherry under the direction of the Tenascin C (Tnc) promoter/enhancer region within a BAC transgene. Expression is observed in a number of tissues during embryonic development.

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