These Pdha1flox8 mutant mice possess loxP sites flanking exon 8 of the pyruvate dehydrogenase E1 alpha 1 (Pdha1) gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. PDHA1 is catalytic component of the pyruvate dehydrogenase complex (PDC) which is a mitochondrial multienzyme complex involved in lipid synthesis, glucose homeostasis, and metabolism of carbohydrates. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 8 deleted in cre-expressing tissues. For example, when crossed to a strain expressing Cre recombinase in the liver, this mutant mouse strain may be useful for studying lipid metabolism, glucose metabolism, and insulin sensitivity in the liver.
When bred to a strain expressing Cre recombinase in the central and periphal nervous system (see Stock No. 003771 for example), this mutant mouse strain may be useful in studies of neuronal migration, axonal growth and cell-cell interactions.
When bred to a strain expressing Cre recombinase in the oocyte (see Stock No. 003651 for example), this mutant mouse strain may be useful in studies of oogenesis.
When bred to a strain expressing Cre recombinase in skeletal and cardiac muscle (see Stock No. 006475 for example), this mutant mouse strain may be useful in studies of cardiac glucose metabolism.
