This Df(10)5Yey/+ mutant strain contains one copy of mouse Chromosome 10 with the targeted sequence deleted between, and including, the protein arginine N-methyltransferase 2 (Prmt2) gene and the pyridoxal (pyridoxine, vitamin B6) kinase (Pdxk) gene. Heterozygous mice are viable and fertile. This deleted region on the mouse chromosome is one of two regions orthologous to a deleted copy of human Chromosome 21 (Hsa21) which has been implicated in developmental cognitive disabilities like Down Syndrome (DS) and Monosomy 21. Dp(10)5Yey/+ lacks 41 genes on Chromosome 10 which are syntenic to the distal part of human 21q22.3, and is orthologous to genes on Hsa21. These mice exhibit Monosomy 21 related phenotypic defects including impaired contextual conditioning behavior, abnormal spatial learning, and abnormal motor coordination and balance. These mice may be useful for understanding developmental and cognitive disabilities associated with Monosomy 21.

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This Df(10)5Yey/+ mutant strain contains one copy of mouse Chromosome 10 with the targeted sequence deleted between, and including, the protein arginine N-methyltransferase 2 (Prmt2) gene and the pyridoxal (pyridoxine, vitamin B6) kinase (Pdxk) gene. These mice may be useful for understanding developmental and cognitive disabilities associated with Monosomy 21.

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