These Sirt6Co floxed mutant mice possess loxP sites flanking exons 2-3 of the sirtuin 6 (Sirt6) targeted gene. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Sirt6 is a histone deacetylase highly expressed in the central nervous system, which is involved in the regulation of glucose homeostasis, cell fate, and genomic stability. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exons 2-3 deleted in cre-expressing tissues.
For example, when crossed to a strain expressing Nestin-Cre in the central and peripheral nervous system (see Stock No. 003771), this mutant mouse strain exhibits reduced post-natal growth and obesity.
When crossed to a strain expressing Cre Recombinase in the liver (see Stock No. 016832 or Stock No. 016833), this mutant mouse strain exhibits increased glycolysis, triglyceride synthesis, reduced β oxidation, and fatty liver formation.
