Homozygotes/Hemizygotes: Mice that are homozygous for the targeted mutation and hemizygous for the transgene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These double mutant mice produce normal human tau (MAPT), while no endogenous mouse tau (Mapt) is produced. The ht-PAC-N transgenic mouse expresses all 6 human tau isoforms by P24 with the 3 repeat (3R)-tau predominant to the 4 repeat (4R) -tau ratio. This strain serves as a control for human tau mutations associated with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP 17). No gross or microscopic pathologic lesions were observed in these mice.

This mutant mouse strain may be useful in studies of tau isoforms in neurodegenerative disease.


Heterozygote: Not evaluated.

These double mutant (ht-PAC-N) mice produce normal human tau (MAPT), while no endogenous mouse tau (Mapt) is produced. This strain serves as a control for human tau mutations associated with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP 17). 

This mutant mouse strain may be useful in studies of tau isoforms in neurodegenerative disease.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.