C57BL/6J-Krt71^Ca-17J/GrsrJ

Stock number: 017307
Research areas: Dermatology Research

Description

This strain has been discontinued, but other caracul alleles are available and DNA for this allele is available.

Detailed description

As with other caracul mutants, heterozygotes have a very wavy coat and curved vibrissae. The mutation can be detected when the coat first comes in at about 7 to 8 days of age, is easily recognized at 3 weeks of age, and remains ruffled throughout life but is less wavy with age.

Development

The caracul 17 Jackson mutation was identified in the progeny of an ENU treated C57BL/6J male at The Jackson Laboratory in 2011. This dominant mutation was maintained segregating on this inbred background.

Allele

Symbol: Krt71^Ca-17J
Name: caracul 17 Jackson
MGI accession ID: MGI:5291635
Generation method: Chemically induced (ENU)
Marker symbol: Krt71
Marker name: keratin 71
Marker synonyms: Ca; Cal4; Cu; HYPT13; K6IRS1; Krt2-6g; KRT6IRS; KRT6IRS1; mK6irs; mK6irs1
Chromosome: 15
Strain of origin: C57BL/6J
Molecular note: A single G-to-A transversion was found at chromsome 15 position 101,736,601 (GRCm38), resulting in an alanine to valine codon change at position 425 (p.A425V).