This strain has been discontinued, but other caracul alleles are available and DNA for this allele is available.
Read More +Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Chemically induced (ENU) | Krt71 | keratin 71 |
As with other caracul mutants, heterozygotes have a very wavy coat and curved vibrissae. The mutation can be detected when the coat first comes in at about 7 to 8 days of age, is easily recognized at 3 weeks of age, and remains ruffled throughout life but is less wavy with age.
The caracul 17 Jackson mutation was identified in the progeny of an ENU treated C57BL/6J male at The Jackson Laboratory in 2011. This dominant mutation was maintained segregating on this inbred background.
Allele Name | caracul 17 Jackson |
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Allele Type | Chemically induced (ENU) |
Allele Synonym(s) | |
Gene Symbol and Name | Krt71, keratin 71 |
Gene Synonym(s) | |
Strain of Origin | C57BL/6J |
Chromosome | 15 |
Molecular Note | A single G-to-A transversion was found at chromsome 15 position 101,736,601 (GRCm38), resulting in an alanine to valine codon change at position 425 (p.A425V). |
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