Overview

This strain has been discontinued, but other caracul alleles are available and DNA for this allele is available.

Genetic overview

Genetic Background	Generation

Krt71^Ca-17J

Allele Type	Gene Symbol	Gene Name
Chemically induced (ENU)	Krt71	keratin 71

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Research Applications

Dermatology Research

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Details

Detailed Description

As with other caracul mutants, heterozygotes have a very wavy coat and curved vibrissae. The mutation can be detected when the coat first comes in at about 7 to 8 days of age, is easily recognized at 3 weeks of age, and remains ruffled throughout life but is less wavy with age.

Development

The caracul 17 Jackson mutation was identified in the progeny of an ENU treated C57BL/6J male at The Jackson Laboratory in 2011. This dominant mutation was maintained segregating on this inbred background.

Control Suggestions

Wild-type from the colony
000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Karst SY; Berry ML; Bergstrom DE; Donahue LR. 2011. Caracul 17 Jackson, a remutation in keratin 71 MGI Direct Data SubmissionMGI: J:176415

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Genetics

Krt71^Ca-17J

Allele Symbol: Krt71^Ca-17J

Allele Name	caracul 17 Jackson
Allele Type	Chemically induced (ENU)
Allele Synonym(s)
Gene Symbol and Name	Krt71, keratin 71
Gene Synonym(s)
Strain of Origin	C57BL/6J
Chromosome	15
Molecular Note	A single G-to-A transversion was found at chromsome 15 position 101,736,601 (GRCm38), resulting in an alanine to valine codon change at position 425 (p.A425V).

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Krt71^Ca-17J related

Dermatology Research
- Skin and Hair Texture Defects

Mammalian Phenotype Terms by Genotype

The following phenotype relates to a compound genotype created using this strain

Genotype: Krt71^Ca-17J/Krt71⁺
C57BL/6J-Krt71/GrsrJ

integument phenotype

waved hair
- evident when the first coat comes in, pronounced very wavy coat by 3 weeks of age, and ruffled coat persists but becomes less wavy with age

curly vibrissae
- very curved vibrissae

References

Karst SY; Berry ML; Bergstrom DE; Donahue LR. 2011. Caracul 17 Jackson, a remutation in keratin 71 MGI Direct Data SubmissionMGI: J:176415

Additional - Krt71^Ca-17J related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Genotyping resources and troubleshooting
Mating System
- Heterozygote x +/+ sibling
- +/+ sibling x Heterozygote

Terms Of Use

General Terms and Conditions

Questions about Terms of Use

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

Genetic overview

Research Applications

Detailed Description

Development

Control Suggestions

Additional Information

Selected References

Krt71Ca-17J

Allele Symbol: Krt71Ca-17J

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: Krt71Ca-17J related

Mammalian Phenotype Terms by Genotype

Genotype: Krt71Ca-17J/Krt71+C57BL/6J-Krt71/GrsrJ

integument phenotype

References

Additional - Krt71Ca-17J related

Genotyping Protocols

Mating System

Terms Of Use

Licensing Information

Krt71^Ca-17J

Allele Symbol: Krt71^Ca-17J

Genotype: Krt71^Ca-17J related

Genotype: Krt71^Ca-17J/Krt71⁺
C57BL/6J-Krt71/GrsrJ

Additional - Krt71^Ca-17J related