As with other caracul mutants, heterozygotes have a very wavy coat and curved vibrissae. The mutation can be detected when the coat first comes in at about 7 to 8 days of age, is easily recognized at 3 weeks of age, and remains ruffled throughout life but is less wavy with age.
The caracul 17 Jackson mutation was identified in the progeny of an ENU treated C57BL/6J male at The Jackson Laboratory in 2011. This dominant mutation was maintained segregating on this inbred background.
|Allele Name||caracul 17 Jackson|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||Krt71, keratin 71|
|Strain of Origin||C57BL/6J|
|Molecular Note||A single G-to-A transversion was found at chromsome 15 position 101,736,601 (GRCm38), resulting in an alanine to valine codon change at position 425 (p.A425V).|