These transgenic mice express the human complement component (3b/4b) receptor 1 (Knops blood group), CR1, under the control of the mouse Gata1, GATA binding protein 1, promoter. Transgene expression is detected on erythrocytes by flow cytometry. Unlike erythrocytes from wildtype controls, erythrocytes from transgenic mice will adhere beads coated with human or mouse serum complement. Transgenic erythrocytes exhibit increased adherence of pneumococci and type 5 adenovirus as well as increased Plasmodium falciparum merozoite invasion when compared to wildtype controls. The donating investigator reports that this transgene is located on the X chromosome. Mice hemizygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.

These transgenic mice express human complement receptor 1, CR1, on erythrocytes.
Erythrocytes from transgenic mice will adhere to beads coated with human or mouse serum complement, an attribute that may prove useful in studies of immune adherence and pathogen clearance.

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