BKS(Cg)-Dab1^scm-5J/GrsrJ

Stock number: 016903
Research areas: Developmental Biology Research, Neurobiology Research

Description

This mutation, like other mutations in the disabled 1 gene, is valuable for studying brain development and neuronal migration during development.

Detailed description

Mice homozygous for the scrambler 5 Jackson mutation are thin, weak, ataxic and nearly all die by three weeks of age. None have survived beyond four weeks of age. By two weeks of age homozygotes can be identified by their severely unstable gait and inability to right themselves. Histology of the brain shows the scrambled arrangement of the cerebral cortex, hippocampus, and cerebellum that is found in other Dab1 mutants.

Development

The scrambler 5 Jackson arose spontaneously at The Jackson Laboratory in the BKS/Cg-Dock7^m +/+ Lepr^db/J strain. Because homozygotes do not survive weaning so do not breed this strain has been maintained by breeding homozygous ovarian transplant hosts with C57BLKS/J and intercrossing the obligate heterozygous offspring. The misty and diabetes mutation have been bred out of this mutant subline. This strain reached backcross generation N4 in June, 2014.

Allele

Symbol: Dab1^scm-5J
Name: scrambler 5 Jackson
MGI accession ID: MGI:5568221
Generation method: Spontaneous
Attributes: Not Specified
Marker symbol: Dab1
Marker name: disabled 1
Chromosome: 4
Strain of origin: BKS.Cg-Dock7^m +/+ Lepr^db/J
Molecular note: This spontaneous mutation mapped between Chromosome 4 position 85,096,243 bp and 119,566,789 bp (MGSCv37) and a failed complementation test with scrambler 4 Jackson proved this an allele of disabled 1.