This mutation, like other mutations in the disabled 1 gene, is valuable for studying brain development and neuronal migration during development.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Not Specified) | Dab1 | disabled 1 |
Mice homozygous for the scrambler 5 Jackson mutation are thin, weak, ataxic and nearly all die by three weeks of age. None have survived beyond four weeks of age. By two weeks of age homozygotes can be identified by their severely unstable gait and inability to right themselves. Histology of the brain shows the scrambled arrangement of the cerebral cortex, hippocampus, and cerebellum that is found in other Dab1 mutants.
The scrambler 5 Jackson arose spontaneously at The Jackson Laboratory in the BKS/Cg-Dock7m +/+ Leprdb/J strain. Because homozygotes do not survive weaning so do not breed this strain has been maintained by breeding homozygous ovarian transplant hosts with C57BLKS/J and intercrossing the obligate heterozygous offspring. The misty and diabetes mutation have been bred out of this mutant subline. This strain reached backcross generation N4 in June, 2014.
Allele Name | scrambler 5 Jackson |
---|---|
Allele Type | Spontaneous (Not Specified) |
Allele Synonym(s) | |
Gene Symbol and Name | Dab1, disabled 1 |
Gene Synonym(s) | |
Strain of Origin | BKS.Cg-Dock7m +/+ Leprdb/J |
Chromosome | 4 |
Molecular Note | This spontaneous mutation mapped between Chromosome 4 position 85,096,243 bp and 119,566,789 bp (MGSCv37) and a failed complementation test with scrambler 4 Jackson proved this an allele of disabled 1. |
When using the BKS(Cg)-Dab1scm-5J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #016903 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Progeny testing required but not provided. No genotyping assay is available for these recessive cryo-recovered animals of undefined genotype |
Frozen Mouse Embryo | BKS(Cg)-Dab1<scm-5J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | BKS(Cg)-Dab1<scm-5J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | BKS(Cg)-Dab1<scm-5J>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | BKS(Cg)-Dab1<scm-5J>/GrsrJ | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.