Mice homozygous for the spontaneous recessive small roller mutation can usually be identified by 2 weeks of age by their difficulty in walking, which persists into adulthood.  The hind legs splay, the gait has a severe side-to-side sway with the body held lower than normal, and homozygotes often tumble over.  They have difficulty righting.  Homozygotes are also smaller than normal, half normal size at wean age and growing to three quarters normal size as adults.  Homozygous females have smaller than normal litter sizes, often produce fewer than expected numbers of homozygotes, and have a high number of stillborn and lost newborns.  Heterozygous intercrosses also produce a high number of stillborn and lost newborns.  Male homozygotes might not be fertile.

This spontaneous mutant has a neurological defect causing ataxia, difficulty righting, and small body size

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