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STOCK ey4/BOC
Stock No: 016848
  • Spontaneous Mutation
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  • Overview
  • Details
    • Detailed Description
    • Development
    • Control Suggestions
    • Selected References
  • Genetics
  • Disease/Phenotype
    • Disease Terms
    • Research Areas By Phenotype
    • Mammalian Phenotype Terms by Genotype
    • References
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    • Genotyping Protocols
    • Mating System
    • Breeder Pairs
    • Citation
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Overview

Mice homozygous for the eyeless 4 mutation display anophthalmia and lens-cornea synechia.

Donating Investigator

Dr. Bo Chang, JAX

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Genetic overview

Genetic Background Generation
F21
(2016-12-29 00:00:00)

ey4

Allele Type Gene Symbol Gene Name
Spontaneous ey4 eyeless 4
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Research Applications

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Base Price

Starting at:

$219.51 Domestic price for female
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Details

Detailed Description

Mice homozygous for the eyeless 4 mutation display anophthalmia and lens-cornea synechia.

Development

The eyeless 4 mutation was identified in the C3Bir.129P2(B6)-Il10tm1Cgn/Lt strain by the laboratory of Dr. Bo Chang at The Jackson Laboratory. The targeted mutation was removed from this line through backcrossing to C57BL/6J, but this line has not been backcrossed to the point of congenicity and has been bred to homozygosity for eyeless 4.

Control Suggestions

Approximate Controls

  • 000664 C57BL/6J

Additional Information

  • Considerations for Choosing Controls

Selected References

  • Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93PubMed: 16332269MGI: J:156373
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Genetics

ey4

Allele Symbol: ey4

Allele Name eyeless 4
Allele Type Spontaneous
Allele Synonym(s)
Gene Symbol and Name ey4, eyeless 4
Gene Synonym(s)
Strain of Origin C3Bir.129P2(B6)-Il10tm1Cgn/Lt
Chromosome 2
Molecular Note This spontaneous mutation was identified at The Jackson Laboratory.

Disease/Phenotype

Disease Terms

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain

Genotype: ey4/ey4
involves: 129P2/OlaHsd * C57BL/6 * C3H/HeJBir

vision/eye phenotype

  • abnormal lens morphology
    • lens-cornea synechia
    • (MGI Ref ID J:156373)
  • abnormal cornea morphology
    • lens-cornea synechia
    • (MGI Ref ID J:156373)
  • anophthalmia
      (MGI Ref ID J:156373)

References

  • Chang B; Hawes NL; Hurd RE; Wang J; Howell D; Davisson MT; Roderick TH; Nusinowitz S; Heckenlively JR. 2005. Mouse models of ocular diseases. Vis Neurosci 22(5):587-93PubMed: 16332269MGI: J:156373

Additional - ey4 related

Technical Support

CONTACT TECHNICAL SUPPORT
  • Genotyping Protocols

    • Genotyping resources and troubleshooting
  • Mating System

    • Homozygote x Homozygote
  • Citation

    When using the STOCK ey4/BOC mouse strain in a publication, please cite the originating article(s) and include JAX stock #016848 in your Materials and Methods section.

Animal Health Reports

Facility Barrier Level Descriptions

MGL277 (Low)

Pricing & Availability

Availability Varies
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Live Mouse

Age Genotype Price
weeks

Cryorecovery - Pricing

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Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.

Terms Of Use

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Phone: 207-288-6470
Email: TechTran@jax.org

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