cardiovascular system phenotype

• increased systemic arterial systolic blood pressure
  • after induction with PiPc, 7-mo-old mice exhibit increased systolic blood pressure relative to control mice
  (MGI Ref ID J:121798)

mammalian phenotype

• growth/size/body region phenotype
  • Normal - after induction with PiPc at 4 weeks of age, mice exhibit no significant differences in body weight relative to control mice, as shown at 7 and 24 months of age
  (MGI Ref ID J:121798)
  • Normal - after induction with IFN at 24-28 days of age, mice exhibit normal postnatal body growth up to 53 days of age relative to control mice
  (MGI Ref ID J:55718)

• renal/urinary system phenotype
  • Normal - after induction with PiPc, 6-mo-old mice exhibit no significant differences in serum and urine creatinine levels, GFR, creatinine clearance, or 24-hr urine volume relative to control mice
  (MGI Ref ID J:121798)
  • Normal - no glomerulosclerosis, vascular defects, mesangial sclerosis, or cortical fibrosis is observed at 24 months of age
  (MGI Ref ID J:121798)

• homeostasis/metabolism phenotype
  • Normal - after induction with PiPc, 6-mo-old mice exhibit no significant differences in serum and urine creatinine levels relative to control mice
  (MGI Ref ID J:121798)

renal/urinary system phenotype

• increased urine sodium level
  • after induction with PiPc, 6-mo-old mice exhibit increased 24-hr sodium excretion relative to control mice
  (MGI Ref ID J:121798)

• increased urine potassium level
  • after induction with PiPc, 6-mo-old mice exhibit increased 24-hr potassium excretion relative to control mice
  (MGI Ref ID J:121798)

• decreased kidney weight
  • after induction with PiPc, absolute and relative kidney weight is reduced in 7- and 24-month-old mice relative to control mice
  (MGI Ref ID J:121798)

homeostasis/metabolism phenotype

• decreased circulating insulin-like growth factor I level
  • after induction with PiPc at 4 weeks of age, mice exhibit a 80-85% reduction in serum IGF-I levels relative to control mice, still evident at 24 months of age
  (MGI Ref ID J:121798)
  • renal IGF-II mRNA levels are reduced by 79%, suggesting that the effects of circulating IGF-I on kidney size may be mediated by renal IGF-II; however, no differences in serum IGF-II levels are observed at 9 months
  (MGI Ref ID J:121798)
  • after induction with IFN at 24-28 days of age, mice exhibit a 75% reduction in serum IGF-I levels relative to control mice, still evident at 53 days of age
  (MGI Ref ID J:55718)

• increased circulating growth hormone level
  • after induction with PiPc, mice exhibit compensatory increased circulating GH levels relative to control mice
  (MGI Ref ID J:121798)

• increased urine sodium level
  • after induction with PiPc, 6-mo-old mice exhibit increased 24-hr sodium excretion relative to control mice
  (MGI Ref ID J:121798)

• increased urine potassium level
  • after induction with PiPc, 6-mo-old mice exhibit increased 24-hr potassium excretion relative to control mice
  (MGI Ref ID J:121798)

homeostasis/metabolism phenotype

• decreased circulating insulin-like growth factor I level
  • male mutant LID (LID, chronic liver-specific IGF-1 deficiency) mice fed a high calorie or regular diet for 8 to 10 weeks exhibit decreased serum IGF-1 levels relative to controls
  (MGI Ref ID J:155733)

• increased circulating leptin level
  • LID mice fed a high calorie for 8 to 10 weeks exhibit increased serum leptin levels compared to lean LID mice (fed a regular diet)
  (MGI Ref ID J:155733)

neoplasm

• decreased tumor growth/size
  • to lean controls
  (MGI Ref ID J:155733)
  • male double mutant (LID, chronic liver-specific IGF-1 deficiency) mice on a high calorie diet for 10-14 weeks and injected with subcutaneous MC-39 murine colorectal carcinoma cell do not show the obesity-associated increase in local tumor growth compared to lean controls
  (MGI Ref ID J:155733)

normal phenotype

• no abnormal phenotype detected
  (MGI Ref ID J:69517)

growth/size/body region phenotype

• slow postnatal weight gain
  • 72% of control weight at 3 weeks of age, 68% at 6 weeks
  (MGI Ref ID J:49468)

• fetal growth retardation
  • fetus at E19 or E20 weighs only 69% as much as comparable controls
  (MGI Ref ID J:49468)

mortality/aging

• perinatal lethality, incomplete penetrance
  • some perinatal mortality but many survive
  (MGI Ref ID J:49468)