These mice carry the ROSAbetageo+1 gene trap inserted into the mouse Usf1 (upstream transcription factor 1) gene.
Dr. Joseph S. Takahashi, Univ Texas Southwestern Medical Ctr
Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Gene trapped (Reporter, Null/Knockout) | Usf1 | upstream transcription factor 1 |
These mice carry the ROSAbetageo+1 gene trap inserted into the mouse Usf1 (upstream transcription factor 1) gene. USF1 is involved with embryonic development, and is implicated as an antagonist of c-Myc protooncoprotein in the control of cellular proliferation. Suppression of Clock gene-regulated circadian period has also been noted in mice overexpressing Usf1. In humans, this gene has been linked to familiar combined hyperlipidemia (FCHL).
The ROSAbetageo+1 gene trap vector (incorporating fused beta galactosidase and neomycin) was introduced to 129S2/SvPas-derived TBV2 embryonic stem (ES) cells to generate mutant cell lines. Clone W233A07 cells (German Gene Trap Consortium), carrying a vector insertion in the Usf1 gene, were used to generate mice which were backcrossed to C57BL/6J for more than 6 generations by the donating laboratory. The gene trap was localized to Chr1:17341444-173349273 bp (+ strand).
Allele Name | gene trap W233A07, German Gene Trap Consortium |
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Allele Type | Gene trapped (Reporter, Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Usf1, upstream transcription factor 1 |
Gene Synonym(s) | |
Strain of Origin | 129S2/SvPas |
Chromosome | 1 |
Molecular Note | Trapped gene association determined by genome coordinate overlap and strand. |
Mutations Made By | Wolfgang Wurst, HelmholtzZentrum Muenchen |
When maintained as a live colony, heterozygotes may be bred.
When using the B6.129S2-Usf1Gt(W233A07)Wrst/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #016579 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous or wildtype for Usf1<Gt(W233A07)Wrst> |
Frozen Mouse Embryo | B6.129S2-Usf1<Gt(W233A07)Wrst>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.129S2-Usf1<Gt(W233A07)Wrst>/J Frozen Embryo | $2595.00 |
Frozen Mouse Embryo | B6.129S2-Usf1<Gt(W233A07)Wrst>/J Frozen Embryo | $3373.50 |
Frozen Mouse Embryo | B6.129S2-Usf1<Gt(W233A07)Wrst>/J Frozen Embryo | $3373.50 |
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