SWR(Cg)-Elovl3^burf/GrsrJ

Stock number: 016267
Product name: buttery rumpled fur
Research areas: Dermatology Research, Metabolism Research, Sensorineural Research

Description

This allele is now only available from a cryopreserved sperm banksotck that will be recovered using BALB/cByJ oocytes. Please see stock #024182 to order a cryorecovery.

Development

The buttery ruffled fur phenotypic mutant was identified in a predominantly SWR/J background in which the X Chromosome had segments from SJL/J and CAST/EiJ. This recessive mutation has been maintained by sibling intercrossing for many generations.

Allele

Symbol: Elovl3^burf
Name: buttery rumpled fur
MGI accession ID: MGI:5556073
Generation method: Spontaneous
Marker symbol: Elovl3
Marker name: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3
Chromosome: 19
Strain of origin: SWR/J
Molecular note: This spontaneous G-to-A transition at chromosome 19 position 46,133,123 bp (GRCm38) eliminates the exon 2 splice acceptor site by changing it from CAG to CAA, which is expected to yield a functional null but this has not been confirmed with transcript or protein analysis.