Mice homozygous for the spontaneous mutation Foxn1nu-2J are athymic, and therefore T cell deficient and useful where an immunocompromised host is needed.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Foxn1 | forkhead box N1 |
Mice homozygous for the nude 2 Jackson mutation can be identified by approximately 1 week of age by their wrinkly skin. Histology of the skin shows severe follicular dystrophy and their hair fails to grow in leaving them hairless throughout their shortened lifespan. Homozygotes are athymic, smaller than normal, and have short, curled, or sparse vibrissae. Females have small litters or fail to produce pups.
The nude 2 Jackson mutation was first identified in the congenic strain B6.SJL-Ptprca Pepcb/BoyJ at The Jackson Laboratory and was maintained by backcross-intercross to C57BL/6J to breed out the SJL-derived polymorphisms.
Allele Name | nude 2 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Foxn1, forkhead box N1 |
Gene Synonym(s) | |
Strain of Origin | B6.SJL-Ptprca Pepcb/BoyJ |
Chromosome | 11 |
Molecular Note | This spontaneous mutation, which fails to complement the original nude mutation, has a 7 nucleotide deletion encompassing chromosome 11 nucleotides 78,371,200-206 (GRCm38). This causes a frameshift that leads to the introduction of 186 novel amino acids beginning at residue 114 and then an early termination codon within the forkhead DNA binding domain. |
Homozygotes are athymic and therefore T cell deficient and immunocompromised. Female homozygotes have reduced fertility and litter size.
When using the B6(SJL)-Foxn1nu-2J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #016195 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for -Foxn1<nu-2J> |
Frozen Mouse Embryo | B6(SJL)-Foxn1<nu-2J>/GrsrJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6(SJL)-Foxn1<nu-2J>/GrsrJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6(SJL)-Foxn1<nu-2J>/GrsrJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6(SJL)-Foxn1<nu-2J>/GrsrJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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