B6(SJL)-Foxn1^nu-2J/GrsrJ

Stock number: 016195
Research areas: Dermatology Research, Developmental Biology Research, Hematological Research, Immunology, Inflammation and Autoimmunity Research, Internal/Organ Research, Research Tools

Description

Mice homozygous for the spontaneous mutation Foxn1^nu-2J are athymic, and therefore T cell deficient and useful where an immunocompromised host is needed.

Detailed description

Mice homozygous for the nude 2 Jackson mutation can be identified by approximately 1 week of age by their wrinkly skin. Histology of the skin shows severe follicular dystrophy and their hair fails to grow in leaving them hairless throughout their shortened lifespan. Homozygotes are athymic, smaller than normal, and have short, curled, or sparse vibrissae. Females have small litters or fail to produce pups.

Development

The nude 2 Jackson mutation was first identified in the congenic strain B6.SJL-Ptprc^a Pepc^b/BoyJ at The Jackson Laboratory and was maintained by backcross-intercross to C57BL/6J to breed out the SJL-derived polymorphisms.

Allele

Symbol: Foxn1^nu-2J
Name: nude 2 Jackson
MGI accession ID: MGI:5464997
Generation method: Spontaneous
Marker symbol: Foxn1
Marker name: forkhead box N1
Marker synonyms: D11Bhm185e; FKHL20; Hfh11; Rnu; RONU; TIDAND; TLIND; whn
Chromosome: 11
Strain of origin: B6.SJL-Ptprc^a Pepc^b/BoyJ
Molecular note: This spontaneous mutation, which fails to complement the original nude mutation, has a 7 nucleotide deletion encompassing chromosome 11 nucleotides 78,371,200-206 (GRCm38). This causes a frameshift that leads to the introduction of 186 novel amino acids beginning at residue 114 and then an early termination codon within the forkhead DNA binding domain.