In this transgenic strain, the mouse Per1 (period homolog 1 (Drosophila)) promoter drives in vivo and in vitro expression of luciferase in a pattern recapitulating that of circadian rhythms in the suprachiasmatic nuclei (SCN). Long-term circadian rhythms of luminescence are also seen in SCN slice culture. Pulses of light rapidly induce high luciferase mRNA expression in the SCN that, unlike endogenous Per1 mRNA levels, are sustained and do not return to baseline. This P1L141 line exhibits highly specific SCN expression. Luciferase riboprobe hybridization signal intensities indicate that among the various transgenic lines made by this research group, copy number does not correlate well with expression levels (possibly due to integration site differences). This strain is reported to carry approximately 10 copies of the transgene, but copy number analysis performed at the Jackson laboratory indicates that transgenic line 128 (see Stock No. <a href="https://www.jax.org/strain/016165">016165</a>) is of higher luciferase copy number than transgenic line 141 (see Stock No. <a href="https://www.jax.org/strain/016166">016166</a>).

The mouse Per1 (period homolog 1 (Drosophila)) promoter drives in vivo and in vitro expression of luciferase in a pattern recapitulating that of circadian rhythms in this transgenic strain. These mice may be useful in studies of circadian and photic regulation of the mammalian circadian oscillator.

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