Homozygotes: Homozygous embryos die between E11.5 and E12.5 due to a severe liver defect. Expected Mendelian numbers of embryos are recovered at E11.5 and appear normal, however, by E12, embryos exhibit a significant reduction in liver size, a progressively pale yolk sac and developmental retardation. By E12.5, all embryos are dead. By E11.5, fetal livers have few hematopoietic cells, an accumulation of blood in enlarged live spaces, many cells with pyknotic nuclei and few erythroid cells. Hematopoietic tissues including erythroid and myeloid/granuloid progenitors are significantly reduced in the yolk sac, fetal liver and peripheral blood. This mutant mouse strain may be useful in studies of RNA editing and hematopoiesis.

Heterozygote: Mice that are heterozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities.

These Adar knockout mice die between E11.5 and E12.5 due to a severe liver defect. Hematopoietic tissues including erythroid and myeloid/granuloid progenitors are significantly reduced in the yolk sac, fetal liver and peripheral blood. This mutant mouse strain may be useful in studies of RNA editing and hematopoiesis.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.