Mice homozygous for the targeted mutation are viable and fertile. Homozygous mutant mice show no overt phenotypic abnormalities. When used in conjunction with a Cre recombinase-expressing strain, this strain is useful in generating tissue-specific mutants of the floxed allele. Widespread excision of the floxed fragment in homozygous mutants during embryogenesis results in embryonic lethality between E11 and E12.5. Widespread apoptosis is detected in tissues at E10.5 to E11.5, however, embryos appear grossly normal with the exception of occasional pallor and reduced size. This mutant strain is useful in organ specific studies involving embryogenesis and stress induced apoptosis.
Heterozygote: Normal

These Adarflox mutant mice may be useful in organ specific studies involving embryogenesis and stress induced apoptosis.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.