This recessive spontaneous single G deletion, predicted to result in a frameshift mutation, causes head tossing, circling, otitis media, hearing impairment, abnormal hair pattern, curled tail, reduced fertility, reduced in utero viability, and smaller body size.
Read More +Genetic Background | Generation |
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001026 BALB/cByJ |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous (Null/Knockout) | Celsr1 | cadherin, EGF LAG seven-pass G-type receptor 1 |
Curly tail bobber homozygotes may display head tossing, circling, otitis media, hearing impairment, abnormal hair pattern, curled/wavy tail or small size in comparison to littermates. The fur, most noticeably on the rump, can grow in reverse orientation leading to an overall ruffled coat appearance. The phenotype varies from animal to animal. Some mice that exhibited only small body size and wavy tails proved to be homozygotes, and the head bobbing and circling phenotypes also range from severe to mild. Homozygotes seldom breed, although they do live a normal lifespan. Histology on two males at ten months of age found otitis media, testicular atrophy and mild hydrocephalus. Cross sections of ears from three homozygotes found otitis media in all three and auditory brainstem response (ABR) analysis at four and five weeks of age found moderate to severe hearing loss. No hearing loss or abnormal phenotype was found in heterozygotes. Heterozygous intercrosses yield fewer than 21% homozygotes.
The curly tail bobber mutation arose spontaneously in the CByJ.Cg-Foxn1nu/J strain in 1999, when that strain was at backcross generation N21. This mutant subline was maintained by sibling intercrossing for five generations then oocytes from a homozygous female were transplanted into a host female, which was bred to BALB/cByJ. The obligate heterozygous offspring were intercrossed and the line was then maintained again by sibling intercrossing. The nude phenotype was never seen in this mutant subline. In 2014 sperm was cryopreserved from homozygous males at generation N21+F5N1F21.
Allele Name | curly tail bobber |
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Allele Type | Spontaneous (Null/Knockout) |
Allele Synonym(s) | |
Gene Symbol and Name | Celsr1, cadherin, EGF LAG seven-pass G-type receptor 1 |
Gene Synonym(s) | |
Strain of Origin | CByJ.Cg-Foxn1nu/J |
Chromosome | 15 |
Molecular Note | This spontaneous single-nucleotide deletion of G (C forward strand) at chromosome 15 position 85,959,170 bp (GRCm38) causes a frameshift and subsequent premature stop codon. |
When using the curly tail bobber mouse strain in a publication, please cite the originating article(s) and include JAX stock #016111 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or wildtype for Celsr1<ctb> |
Frozen Mouse Embryo | CByJ.Cg-Celsr1<ctb>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | CByJ.Cg-Celsr1<ctb>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | CByJ.Cg-Celsr1<ctb>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | CByJ.Cg-Celsr1<ctb>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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