In this strain, a neomycin resistance (neo) cassette replaces exon 3 of the p21 protein (Cdc42/Rac)-activated kinase 5 (Pak5, formerly Pak7) gene, abolishing gene expression. Homozygotes are viable, fertile, normal in size, and do not display any gross physical abnormalities. Pak5 is a member of the group B family of PAK serine/threonine kinases and is expressed in the cortex, striatum, hypothalamus, cerebellum, and hippocampus. It is involved in neuronal growth and filopodia formation. The absence of a significant aberrant phenotype in these mice may be due to the compensatory actions of Pak6 (p21 protein (Cdc42/Rac)-activated kinase 6). When maintained on a background also lacking Pak6 activity, these mice have impaired cognitive function and deficits in learning and memory retention. These mice may be useful for studying learning, memory, and locomotion.

These Pak5 (formerly Pak7) knock-out mice may be useful for studying learning, memory, and locomotion.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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