CD4-PLZF transgenic mice contain CD4 promoter/enhancer elements driving expression of the zinc finger and BTB domain containing 16 (Zbtb16 or PLZF) cDNA from purified natural killer T (NKT cells). Hemizygous mice are viable and fertile. PLZF is a transcriptional regulator that is expressed in NKT cells and is required for their maturation into effector-type lymphocytes. Transgenic expression of PLZF using the CD4 promoter induces 
conventional CD4 T cells to acquire effector characteristics. While 
CD4 T cells are present at normal levels in the thymus, spleen, liver, 
and lungs of the CD4-PLZF mouse, they are nearly absent in the blood 
and lymph nodes. Greater than 98% of mature CD4 T cells display a 
CD44hi/CD62Llo effector phenotype. An increased percentage of CD4 T cells produce both interleukin-4 (IL-4) and interferon (IFN) &gamma; upon TCR stimulation. These mice may be useful for studying the function 
of PLZF in T cells.

CD4-PLZF transgenic mice contain CD4 promoter/enhancer elements driving expression of the zinc finger and BTB domain containing 16 (Zbtb16 or PLZF) cDNA from purified natural killer T (NKT cells). These mice may be useful for studying the function 
of PLZF in T cells.

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