Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. However, more than half of all homozygous females suffer dystocia after pregnancy. Mice exhibit reduced numbers of CD19+ B cells. The reduction in B cells is first observed at the pre-pro B to pro-B transition in the bone marrow. Marginal zone B cells persist in normal numbers. The donating investigator reports that mice develop hyperbilirubinemia with elevated levels of cholic acid in the serum. This mutant mouse strain may be useful in studies of B cell lymphopoiesis and cholestasis. 
 For additional information, see The Scripps Research Institute <a href="http://mutagenetix.utsouthwestern.edu/phenotypic/phenotypic_rec.cfm?pk=545&rn=4&rl=4&so=al&ac=1&r0=0&nr=500&gsm=atp11c">Mutagenix website</a>.
Heterozygote: Normal

These ENU-induced Atp11c mutant mice exhibit reduced numbers of CD19+ B cells and hyperbilirubinemia with elevated levels of cholic acid in the serum. This mutant mouse strain may be useful in studies of B cell lymphopoiesis and cholestasis.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.