A targeted mutation was designed to insert an enhanced green fluorescent protein sequence (EGFP) sequence in the 3' UTR of the methyl CpG binding protein 2 (Mecp2) gene. Homozygous females and male carriers are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. Mecp2 is located on the X-chromosome, and exhibits increased expression in the central nervous system during neuronal maturation. Mutations in the Mecp2 gene can cause Rett Syndrome, an autism-spectrum neurodevelopmental disorder. Under control of the endogenous Mecp2 promoter, these mice express EGFP in neurons throughout the brain at levels consistent with endogenous MECP2 expression in wildtype mice from the colony. These mice may be useful for visualizing MECP2 expressing neuronal cells.

These mice harbor a knock-in mutation designed to insert an EGFP sequence in the 3' UTR of the Mecp2 gene. These mice may be useful for visualizing MECP2-expressing neuronal cells.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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