These Ple143-lacZ;mEMS4990 mice have the Ple143-lacZ transgene targeted as a single copy "knockin" into the upstream region of hypoxanthine guanine phosphoribosyl transferase 1 (Hprt1) locus on the X chromosome. Heterozygous females and hemizygous males are viable and fertile, with the promoter/regulatory regions of the nuclear receptor subfamily 2, group F, member 2 [NR2F2] gene directing expression of &beta;-galactosidase (lacZ). These Ple143-lacZ;mEMS4990 mice may be useful in studying NR2F2-expressing cells in the brain and diseases affecting the brain. For Ple143-lacZ;mEMS4990 expression information, see The Pleiades Promoter Project website (<a href="http://www.pleiades.org/byminip.php">Ple143 Promoter (bEMS85)</a>). The lacZ expression pattern is described by the donating investigator as: These mice were created and deposited by The Pleiades Promoter Project (Centre for Molecular Medicine and Therapeutics, University of British Columbia).

These mice have the Ple143-lacZ transgene targeted as a single copy "knockin" into the upstream region of the Hprt1 locus on the X chromosome. The promoter/regulatory regions of the human NR2F2 gene direct expression of &beta;-galactosidase.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.