Homozygotes: Mice that are homozygous for the targeted mutation are viable, fertile and normal in size. Mice exhibit vestibular dysfunction by 13 and 21 months of age as determined by elevated measurements of the vestibular evoked potential (VsEP). Auditory brainstem response (ABR) testing at 21 months of age indicates hearing loss at the highest frequencies as determined by elevated or absent ABR thresholds. Histopathology at 21 months of age reveals no hair cell loss or obvious change in morphology. This mutant mouse strain may be useful in studies of late onset hearing loss.


Heterozygote: 
Heterozygous mice do not have hearing loss, but exhibit the same vestibular malfunction at 21 months of age as the homozygous mice.

Mice homozygous for this Coch (coagulation factor C homolog) null allele exhibit vestibular dysfunction, hearing loss at the highest frequencies by 21 months. This mutant mouse strain may be useful in studies of late onset hearing loss.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.