These mice carrying an allele of the loss of righting induced by ethanol 2 (Lore2) from the ISS/Tej strain may be used to study the genetics of neurogenetic, neuropharmacological, and behavioral phenotypes involved in alcohol-related traits.
Thomas Johnson, University of Colorado at Boulder
This allele of the loss of righting induced by ethanol 2 (Lore2) gene from ISS/TejJ (Inbred Short Sleep) exhibits a decrease in the loss of righting response time and an increase in blood ethanol concentration following sedative intraperitoneal ethanol injection on the ILS/TeJ (Inbred Long Sleep) background as compared to the strain ILS/TejJ.
This strain may be used to study the genetics of neurogenetic, neuropharmacological and behavioral phenotypes involved in alcohol-related traits.
This congenic strain was developed by backcrossing ISS/Tej to ILS/TeJ for a minimum of 10 generations, and then intercrossing to generate homozygotes. The Lore2 QTL is defined by D2Mit390 to D2Mit457. This strain and the set of ILSXISS recombinant inbreds and congenics were donated to The Jackson Laboratory Repository in 2011 by Dr. Thomas E. Johnson and Dr. Jerry Stitzel at the University of Colorado, Boulder.
When maintaining a live colony, this mice are bred as homozygotes.
When using the ILS.ISS-Lore2ISS/TejJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #014187 in your Materials and Methods section.