These mice possess loxP sites on either side of exon 2, which encodes the DNA binding domain. Mice that are homozygous for this allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When these mutant mice are bred to mice that express Cre recombinase, resulting offspring will have exon 2 deleted in the cre-expressing tissue(s). When bred to a strain with Cre recombinase expression in B lymphocytes (see Stock No. <a href="https://www.jax.org/strain/006785">006785</a> for example), this mutant mouse strain may be useful in studies of B cell differentiation.

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This Irf8f floxed targeted mutation strain may be useful in generating conditional mutants for studying B cell differentiation, immunodeficiency (abnormal populations of B cells, T cells, granulocytes and macrophages), hematopoiesis, lymphoma and human chronic myeloid leukemia.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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