CBA/J-Atp8a2^agil-3J/GrsrJ

Stock number: 014084
Research areas: Developmental Biology Research, Neurobiology Research

Description

Mice homozygous for the agitans-like 3 Jackson mutation can be detected by 2 weeks of age by a wobbling gait and the propensity to retract the hind legs when picked up by the tail. They are smaller than their littermates and most die before adulthood.

Detailed description

Mice homozygous for the agitans-like 3 Jackson mutation can be detected by 2 weeks of age by a wobbling gait and the propensity to retract the hind legs when picked up by the tail. They are smaller than their littermates and most die before adulthood. Homozygotes fail to breed.

Development

The agitans-like 3 Jackson mutation arose spontaneously in the CBA/J inbred strain at The Jackson Laboratory in 2007 and was maintained coisogenic on this background by sibling intercrossing. In 2012 sperm was cryopreserved from heterozygous males at generation F7.

Allele

Symbol: Atp8a2^agil-3J
Name: agitans-like 3 Jackson
MGI accession ID: MGI:4837728
Generation method: Spontaneous
Attributes: Not Specified
Marker symbol: Atp8a2
Marker name: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
Marker synonyms: agil; ATP; ATPIB; CAMRQ4; IB; ML-1; wl
Chromosome: 14
Strain of origin: CBA/J
Molecular note: A failed complementation test between this spontantous mutation and the agitans-like mutation proved them allelic and a deletion of 2 bp (AA) was found at chromosome 14 60,046,668-60,046,669 bp (GRCm38) that results in a frameshift mutation and premature termination in the coding sequence.