MRL/MpJ-aphl/GrsrJ

Stock number: 013782
Product name: atypical hair loss
Research areas: Dermatology Research

Description

Mutants have stripes of bald patches evident in the first coat and the skin around the eyes can develop a mild, crusty growth and rash.

Detailed description

Homozygotes can be identified as early as 7 to 8 days of age when the first coat comes in. The hair growth is sparse and grows in stripes with bald areas between. The areas around the eyes often develop a mild, crusty growth and rash. All four hair types are present. Of two homozygotes tested both display a low cone response by electroretinograph.

Development

The atypical hair loss (aphl) mutation arose spontaneously at The Jackson Laboratory on the MRL/MpJ-Fas^lpr/J background in 2006 and was backcrossed to MRL/MpJ to via backcross-intercross breeding to remove the Fas^lpr mutation. When this strain reached N6 in 2010 and the Fas^lpr mutation was shown to be removed from the line the breeding scheme changed to sibling mating heterozygotes and homozygotes.

Allele

Symbol: aphl
Name: atypical hair loss
MGI accession ID: MGI:4836501
Generation method: Spontaneous
Marker symbol: aphl
Marker name: atypical hair loss
Chromosome: 6
Strain of origin: MRL/MpJ-Fas^lpr/J
Molecular note: Whole exome sequencing identified candidate mutations in the UTRs of 3 genes, Eif2ak3, Mrpl35, and Usp39, but none has yet been proven causative.