Mutants have stripes of bald patches evident in the first coat and the skin around the eyes can develop a mild, crusty growth and rash.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | aphl | atypical hair loss |
Homozygotes can be identified as early as 7 to 8 days of age when the first coat comes in. The hair growth is sparse and grows in stripes with bald areas between. The areas around the eyes often develop a mild, crusty growth and rash. All four hair types are present. Of two homozygotes tested both display a low cone response by electroretinograph.
The atypical hair loss (aphl) mutation arose spontaneously at The Jackson Laboratory on the MRL/MpJ-Faslpr/J background in 2006 and was backcrossed to MRL/MpJ to via backcross-intercross breeding to remove the Faslpr mutation. When this strain reached N6 in 2010 and the Faslpr mutation was shown to be removed from the line the breeding scheme changed to sibling mating heterozygotes and homozygotes.
Allele Name | atypical hair loss |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | aphl, atypical hair loss |
Gene Synonym(s) | |
Strain of Origin | MRL/MpJ-Faslpr/J |
Chromosome | 6 |
Molecular Note | Whole exome sequencing identified candidate mutations in the UTRs of 3 genes, Eif2ak3, Mrpl35, and Usp39, but none has yet been proven causative. |
When using the atypical hair loss mouse strain in a publication, please cite the originating article(s) and include JAX stock #013782 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for aphl |
Frozen Mouse Embryo | MRL/MpJ-aphl/GrsrJ | $2595.00 |
Frozen Mouse Embryo | MRL/MpJ-aphl/GrsrJ | $2595.00 |
Frozen Mouse Embryo | MRL/MpJ-aphl/GrsrJ | $3373.50 |
Frozen Mouse Embryo | MRL/MpJ-aphl/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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