Expression of Cacnb2 (calcium channel, voltage-dependent, beta 2 subunit) is regulated by a tetracycline operator (tetO); also called tetracycline-responsive element (TRE, TetRE) or tet-operator) in this transgenic strain. When mated to a mutant strain expressing tetracycline-controlled transactivator protein (tTA), expression of CACNB2 protein may be regulated with tetracycline or its analog doxycycline (dox) in the double mutant offspring. When crossed with a Myh6-tTA strain (e.g. Stock No. <a href="https://www.jax.org/strain/003170">003170</a>), double transgenic mice show increased Ca2+ influx through cardiac L-type Ca2+ channels resulting in Ca2+ overload, myocyte disorganization, interstitial fibrosis, and cell death. Compound mutant animals show a 3.1-fold increase in CACNB2 expression. This strain may be useful in studies of cardiomyopathy.

Expression of Cacnb2 (calcium channel, voltage-dependent, beta 2 subunit) is regulated by a tetracycline operator (tetO). This strain may be useful in studies of cardiomyopathy.

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