JAX
Mouse Strain Datasheet - 013762
129-Nr1h3tm1Djm/J
These Nr1h3 knock-out mice lose their ability to respond normally to dietary cholesterol. This strain may be useful in studies involving fertility, innate immunity, metabolism, and the effects of dietary cholesterol, lipids and carbohydrates
Donating Investigator
David Mangelsdorf, UT Southwestern Medical Center
Genetic overview
| Genetic Background | Generation |
|---|---|
|
|
Nr1h3tm1Djm
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Nr1h3 | nuclear receptor subfamily 1, group H, member 3 |
Research Applications
- Cardiovascular Research
- Immunology, Inflammation and Autoimmunity Research
- Internal/Organ Research
- Metabolism Research
- Reproductive Biology Research
Detailed Description
Homozygous Nr1h3 (nuclear receptor subfamily 1, group H, member 3) targeted mutation mice lose their ability to respond normally to dietary cholesterol. Mice maintained on cholesterol diets fail to induce transcription of the Cyp7a1 (cytochrome P450, family 7, subfamily a, polypeptide 1) gene, a rate-limiting enzyme in bile acid synthesis, and fail to induce expression of ABCG5 (ATP-binding cassette, sub-family G (WHITE), member 5) and ABCG8 (ATP-binding cassette, sub-family G (WHITE), member 8), ATP-binding cassette transporters that are required for cholesterol secretion into bile. Large amounts of cholesterol rapidly accumulate in the liver leading to impaired hepatic function. Impaired reverse cholesterol transport from peripheral tissues is also observed. The ability to regulate lipids and carbohydrates is also lost. Defects in innate immune responses by activated macrophages have also been described. Males are not infertile, but show a significantly higher number of testicular apoptotic cells than wildtype mice. Testosterone production is significantly lower. It is not known whether genetic background affects the phenotype associated with this mutation.
Development
Exons 3-6, containing the complete DNA-binding domain and majority of the ligand-binding domain, were replaced with a neomycin resistance cassette. The mutation was created in SM1 embryonic stem (ES) cells derived from 129S6/SvEvTac mice. This strain was backcrossed to a 129-derived strain of unknown subline for seven generations by the donating laboratory.
Control Suggestions
Selected References
- Peet DJ; Turley SD; Ma W; Janowski BA; Lobaccaro JM; Hammer RE; Mangelsdorf DJ. 1998. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93(5):693-704. PubMed: 9630215MGI: J:47971
Nr1h3tm1Djm
Allele Symbol: Nr1h3tm1Djm
| Allele Name | targeted mutation 1, David J Mangelsdorf |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | LXRalpha (-); Nr1h3- |
| Gene Symbol and Name | Nr1h3, nuclear receptor subfamily 1, group H, member 3 |
| Gene Synonym(s) | AU018371; LXR alpha; LXR-a; LXRA; LXRalpha; RLD-1; Unr1; Unr1; expressed sequence AU018371; ubiquitously-expressed nuclear receptor 1 |
| Strain of Origin | 129S6/SvEvTac |
| Chromosome | 2 |
| Molecular Note | Exons 3-6 encoding the DNA-binding and ligand-binding domains (amino acids 87-327) were replaced with a neomycin resistance gene via homologous recombination. Northern blot and Western blot analysis of liver from homozygous mutant animals verified the absence of mRNA and protein expression. |
| Mutations Made By | David Mangelsdorf, UT Southwestern Medical Center |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cardiovascular Research
- Hypercholesterolemia
- Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
- Macrophage defects
- Immunodeficiency
- Internal/Organ Research
- Liver Defects
- Metabolism Research
- Lipid Metabolism
- Reproductive Biology Research
- Fertility Defects
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Nr1h3tm1Djm/Nr1h3tm1Djm
involves: 129S6/SvEvTac * C57BL/6
mortality/aging
- increased sensitivity to induced morbidity/mortality
- mice succumb to infection of Listeria monocytogenes 2-3 days earlier than controls (MGI Ref ID J:81696)
reproductive system phenotype
- abnormal corpus luteum morphology
- superovulated-mice rarely exhibit hemorrhage of the corpus luteum unlike similarly treated wild-type mice (MGI Ref ID J:158168)
- abnormal male germ cell apoptosis
- apoptosis of germ cells within seminiferous tubules is more than double that of controls (MGI Ref ID J:120913)
- abnormal ovary physiology
- following follicle retrieval, a greater number of follicles are expulsed with 45% dead oocytes or empty zonae pellucidae unlike in similarly treated wild-type mice (MGI Ref ID J:158168)
- abnormal superovulation
- superovulated-mice exhibit increased follicle expulsion, increased number of dead oocytes or empty zona pellucida, enlarged ovaries, ovarian cysts, rare ovarian hemorrhage, increased ovarian vascular permeability, circulating estradiol, and inflammation compared with similarly treated wild-type miceompared with similarly treated wild-type mice (MGI Ref ID J:158168)
- enlarged ovary
- ovary cysts
- superovulated-mice exhibit hemorrhagic cysts unlike similarly treated wild-type mice (MGI Ref ID J:158168)
- ovary hemorrhage
- superovulated-mice rarely exhibit hemorrhage of the corpus luteum unlike similarly treated wild-type mice (MGI Ref ID J:158168)
homeostasis/metabolism phenotype
- abnormal bile salt homeostasis
- less fecal excretion of bile acid occurs in mice fed the high cholesterol diet compared to control mice (MGI Ref ID J:47971)
- mice fail to increase their pool of bile acid in response to a high cholesterol diet as wild-type mice do (MGI Ref ID J:47971)
- the ratio of cholic acid to muricholic acid within the bile acid pool is significantly higher than controls on a chow-fed diet, and does not decrease when fed a high cholesterol diet (MGI Ref ID J:47971)
- decreased circulating luteinizing hormone level
- plasma LH levels are almost half that of controls (MGI Ref ID J:120913)
- decreased circulating testosterone level
- testosterone production in the testes is significantly reduced compared to controls (MGI Ref ID J:120913)
- increased circulating LDL cholesterol level
- serum LDL levels are increased 5-fold in mice that are fed a high cholesterol diet (MGI Ref ID J:47971)
- increased circulating alanine transaminase level
- serum alanine transaminase levels are increased in mice that are fed a high cholesterol diet (MGI Ref ID J:47971)
- increased circulating aspartate transaminase level
- serum aspartate transaminase levels are increased in mice that are fed a high cholesterol diet (MGI Ref ID J:47971)
- increased circulating cholesterol level
- there is a 15- to 20- fold increase in liver cholesterol levels 7 days after being switched to a high (2%) cholesterol diet while only a modest increase is observed in control mice (MGI Ref ID J:47971)
- when fed an intermediate (0.2%) cholesterol diet, mice have increases of 3- and 10- fold after 7 and 22 days on the diet (MGI Ref ID J:47971)
- increased circulating estradiol level
- superovulated-mice compared to in similarly treated wild-type (MGI Ref ID J:158168)
- increased liver cholesterol level
- there is a 15- to 20- fold increase in liver cholesterol levels 7 days after being switched to a high (2%) cholesterol diet while only a modest increase is observed in control mice (MGI Ref ID J:47971)
- when fed an intermediate (0.2%) cholesterol diet, mice have increases of 3- and 10- fold after 7 and 22 days on the diet (MGI Ref ID J:47971)
liver/biliary system phenotype
- hepatic steatosis
- on high (2%) cholesterol diets, livers develop fatty deposits that increase in number and size with time while control mice exhibit no abnormalities (MGI Ref ID J:47971)
- the liver appears pale and is double in size, inflammatory foci are developing, and signs of liver degeneration are evident after 3 months on the diet (MGI Ref ID J:47971)
- increased liver cholesterol level
- there is a 15- to 20- fold increase in liver cholesterol levels 7 days after being switched to a high (2%) cholesterol diet while only a modest increase is observed in control mice (MGI Ref ID J:47971)
- when fed an intermediate (0.2%) cholesterol diet, mice have increases of 3- and 10- fold after 7 and 22 days on the diet (MGI Ref ID J:47971)
- increased liver weight
- 3 months on a high cholesterol diet leads to a doubling in liver mass without increasing body weight (MGI Ref ID J:47971)
- liver degeneration
- hepatocytes have lost most of their normal cell structure after 90 days on a high cholesterol diet (MGI Ref ID J:47971)
- increased serum levels of alanine and aspartate amino transferases are also indicitave of liver injury (MGI Ref ID J:47971)
- signs of liver degeneration are evident after 3 months on a high cholesterol diet (MGI Ref ID J:47971)
- pale liver
- liver appears white after 3 months on a high cholesterol diet due to presence of cholesterol filled droplets (MGI Ref ID J:47971)
cardiovascular system phenotype
- increased vascular permeability
- in the ovaries of superovulated-mice compared to in similarly treated wild-type (MGI Ref ID J:158168)
- ovary hemorrhage
- superovulated-mice rarely exhibit hemorrhage of the corpus luteum unlike similarly treated wild-type mice (MGI Ref ID J:158168)
immune system phenotype
- increased inflammatory response
- following superovulation protocols, mice exhibit an increase in blood sediment rate compared with wild-type mice indicating inflammation (MGI Ref ID J:158168)
- increased susceptibility to bacterial infection
endocrine/exocrine gland phenotype
- abnormal corpus luteum morphology
- superovulated-mice rarely exhibit hemorrhage of the corpus luteum unlike similarly treated wild-type mice (MGI Ref ID J:158168)
- abnormal ovary physiology
- following follicle retrieval, a greater number of follicles are expulsed with 45% dead oocytes or empty zonae pellucidae unlike in similarly treated wild-type mice (MGI Ref ID J:158168)
- enlarged ovary
- ovary cysts
- superovulated-mice exhibit hemorrhagic cysts unlike similarly treated wild-type mice (MGI Ref ID J:158168)
- ovary hemorrhage
- superovulated-mice rarely exhibit hemorrhage of the corpus luteum unlike similarly treated wild-type mice (MGI Ref ID J:158168)
cellular phenotype
- abnormal male germ cell apoptosis
- apoptosis of germ cells within seminiferous tubules is more than double that of controls (MGI Ref ID J:120913)
References
- Peet DJ; Turley SD; Ma W; Janowski BA; Lobaccaro JM; Hammer RE; Mangelsdorf DJ. 1998. Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell 93(5):693-704. PubMed: 9630215MGI: J:47971
Additional - Nr1h3tm1Djm related
- A-Gonzalez N; Bensinger SJ; Hong C; Beceiro S; Bradley MN; Zelcer N; Deniz J; Ramirez C; Diaz M; Gallardo G; de Galarreta CR; Salazar J; Lopez F; Edwards P; Parks J; Andujar M; Tontonoz P; Castrillo A. 2009. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 31(2):245-58. PubMed: 19646905MGI: J:151872
- A-Gonzalez N; Guillen JA; Gallardo G; Diaz M; de la Rosa JV; Hernandez IH; Casanova-Acebes M; Lopez F; Tabraue C; Beceiro S; Hong C; Lara PC; Andujar M; Arai S; Miyazaki T; Li S; Corbi AL; Tontonoz P; Hidalgo A; Castrillo A. 2013. The nuclear receptor LXRalpha controls the functional specialization of splenic macrophages. Nat Immunol 14(8):831-9. PubMed: 23770640MGI: J:204819
- A-Gonzalez N; Quintana JA; Garcia-Silva S; Mazariegos M; Gonzalez de la Aleja A; Nicolas-Avila JA; Walter W; Adrover JM; Crainiciuc G; Kuchroo VK; Rothlin CV; Peinado H; Castrillo A; Ricote M; Hidalgo A. 2017. Phagocytosis imprints heterogeneity in tissue-resident macrophages. J Exp Med 214(5):1281-1296. PubMed: 28432199MGI: J:242001
- Astapova I; Ramadoss P; Costa-e-Sousa RH; Ye F; Holtz KA; Li Y; Niepel MW; Cohen DE; Hollenberg AN. 2014. Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRbeta1-governed pathway. J Clin Invest 124(5):1976-86. PubMed: 24713658MGI: J:212761
- Beaven SW; Matveyenko A; Wroblewski K; Chao L; Wilpitz D; Hsu TW; Lentz J; Drew B; Hevener AL; Tontonoz P. 2013. Reciprocal regulation of hepatic and adipose lipogenesis by liver x receptors in obesity and insulin resistance. Cell Metab 18(1):106-17. PubMed: 23823481MGI: J:199232
- Bensinger SJ; Bradley MN; Joseph SB; Zelcer N; Janssen EM; Hausner MA; Shih R; Parks JS; Edwards PA; Jamieson BD; Tontonoz P. 2008. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 134(1):97-111. PubMed: 18614014MGI: J:145492
- Bradley MN; Hong C; Chen M; Joseph SB; Wilpitz DC; Wang X; Lusis AJ; Collins A; Hseuh WA; Collins JL; Tangirala RK; Tontonoz P. 2007. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest 117(8):2337-46. PubMed: 17657314MGI: J:123957
- Cha JY; Repa JJ. 2007. The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR. J Biol Chem 282(1):743-51. PubMed: 17107947MGI: J:154828
- Cui G; Qin X; Wu L; Zhang Y; Sheng X; Yu Q; Sheng H; Xi B; Zhang JZ; Zang YQ. 2011. Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation. J Clin Invest 121(2):658-70. PubMed: 21266776MGI: J:171827
- Cummins CL; Volle DH; Zhang Y; McDonald JG; Sion B; Lefrancois-Martinez AM; Caira F; Veyssiere G; Mangelsdorf DJ; Lobaccaro JM. 2006. Liver X receptors regulate adrenal cholesterol balance. J Clin Invest 116(7):1902-12. PubMed: 16823488MGI: J:111742
- Denechaud PD; Bossard P; Lobaccaro JM; Millatt L; Staels B; Girard J; Postic C. 2008. ChREBP, but not LXRs, is required for the induction of glucose-regulated genes in mouse liver. J Clin Invest 118(3):956-64. PubMed: 18292813MGI: J:135655
- Dufour J; Pommier A; Alves G; De Boussac H; Lours-Calet C; Volle DH; Lobaccaro JM; Baron S. 2013. Lack of liver X receptors leads to cell proliferation in a model of mouse dorsal prostate epithelial cell. PLoS One 8(3):e58876. PubMed: 23554947MGI: J:200167
- Erbay E; Babaev VR; Mayers JR; Makowski L; Charles KN; Snitow ME; Fazio S; Wiest MM; Watkins SM; Linton MF; Hotamisligil GS. 2009. Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med 15(12):1383-91. PubMed: 19966778MGI: J:155873
- Fond AM; Lee CS; Schulman IG; Kiss RS; Ravichandran KS. 2015. Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. J Clin Invest 125(7):2748-58. PubMed: 26075824MGI: J:224549
- Gillespie MA; Gold ES; Ramsey SA; Podolsky I; Aderem A; Ranish JA. 2015. An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux. EMBO J 34(9):1244-58. PubMed: 25755249MGI: J:221042
- Gold ES; Diercks AH; Podolsky I; Podyminogin RL; Askovich PS; Treuting PM; Aderem A. 2014. 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling. Proc Natl Acad Sci U S A 111(29):10666-71. PubMed: 24994901MGI: J:212267
- Henry-Berger J; Mouzat K; Baron S; Bernabeu C; Marceau G; Saru JP; Sapin V; Lobaccaro JM; Caira F. 2008. Endoglin (CD105) expression is regulated by the liver X receptor alpha (NR1H3) in human trophoblast cell line JAR. Biol Reprod 78(6):968-75. PubMed: 18276933MGI: J:140815
- Hernandez Vallejo SJ; Alqub M; Luquet S; Cruciani-Guglielmacci C; Delerive P; Lobaccaro JM; Kalopissis AD; Chambaz J; Rousset M; Lacorte JM. 2009. Short-term adaptation of postprandial lipoprotein secretion and intestinal gene expression to a high-fat diet. Am J Physiol Gastrointest Liver Physiol 296(4):G782-92. PubMed: 19196952MGI: J:149786
- Hong C; Bradley MN; Rong X; Wang X; Wagner A; Grijalva V; Castellani LW; Salazar J; Realegeno S; Boyadjian R; Fogelman AM; Van Lenten BJ; Reddy ST; Lusis AJ; Tangirala RK; Tontonoz P. 2012. LXRalpha is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice. J Lipid Res 53(6):1126-33. PubMed: 22454476MGI: J:184910
- Hong C; Walczak R; Dhamko H; Bradley MN; Marathe C; Boyadjian R; Salazar JV; Tontonoz P. 2011. Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target. J Lipid Res 52(3):531-9. PubMed: 21187453MGI: J:173138
- Ishikawa T; Yuhanna IS; Umetani J; Lee WR; Korach KS; Shaul PW; Umetani M. 2013. LXRbeta/estrogen receptor-alpha signaling in lipid rafts preserves endothelial integrity. J Clin Invest 123(8):3488-97. PubMed: 23867501MGI: J:201404
- Joseph SB; Bradley MN; Castrillo A; Bruhn KW; Mak PA; Pei L; Hogenesch J; O'connell RM; Cheng G; Saez E; Miller JF; Tontonoz P. 2004. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell 119(2):299-309. PubMed: 15479645MGI: J:93893
- Joseph SB; Castrillo A; Laffitte BA; Mangelsdorf DJ; Tontonoz P. 2003. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9(2):213-9. PubMed: 12524534MGI: J:81696
- Kalaany NY; Gauthier KC; Zavacki AM; Mammen PP; Kitazume T; Peterson JA; Horton JD; Garry DJ; Bianco AC; Mangelsdorf DJ. 2005. LXRs regulate the balance between fat storage and oxidation. Cell Metab 1(4):231-44. PubMed: 16054068MGI: J:129844
- Komuves LG; Schmuth M; Fowler AJ; Elias PM; Hanley K; Man MQ; Moser AH; Lobaccaro JM; Williams ML; Mangelsdorf DJ; Feingold KR. 2002. Oxysterol stimulation of epidermal differentiation is mediated by liver X receptor-beta in murine epidermis. J Invest Dermatol 118(1):25-34. PubMed: 11851872MGI: J:89874
- Koroskenyi K; Duro E; Pallai A; Sarang Z; Kloor D; Ucker DS; Beceiro S; Castrillo A; Chawla A; Ledent CA; Fesus L; Szondy Z. 2011. Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation. J Immunol 186(12):7144-55. PubMed: 21593381MGI: J:175472
- Kotti TJ; Ramirez DM; Pfeiffer BE; Huber KM; Russell DW. 2006. Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc Natl Acad Sci U S A 103(10):3869-74. PubMed: 16505352MGI: J:107142
- Kumar N; Wang H; Liu D; Collins S. 2009. Liver X receptor is a regulator of orphan nuclear receptor NOR-1 gene transcription in adipocytes. Int J Obes (Lond) 33(5):519-24. PubMed: 19238156MGI: J:151278
- Laffitte BA; Repa JJ; Joseph SB; Wilpitz DC; Kast HR; Mangelsdorf DJ; Tontonoz P. 2001. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A 98(2):507-12. PubMed: 11149950MGI: J:67239
- Le Martelot G; Claudel T; Gatfield D; Schaad O; Kornmann B; Sasso GL; Moschetta A; Schibler U. 2009. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol 7(9):e1000181. PubMed: 19721697MGI: J:153064
- Lemaire M; Lemarie CA; Flores Molina M; Guilbert C; Lehoux S; Mann KK. 2014. Genetic deletion of LXRalpha prevents arsenic-enhanced atherosclerosis, but not arsenic-altered plaque composition. Toxicol Sci 142(2):477-88. PubMed: 25273567MGI: J:227826
- Lu W; Hisatsune A; Koga T; Kato K; Kuwahara I; Lillehoj EP; Chen W; Cross AS; Gendler SJ; Gewirtz AT; Kim KC. 2006. Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice. J Immunol 176(7):3890-4. PubMed: 16547220MGI: J:129884
- Lund EG; Peterson LB; Adams AD; Lam MH; Burton CA; Chin J; Guo Q; Huang S; Latham M; Lopez JC; Menke JG; Milot DP; Mitnaul LJ; Rex-Rabe SE; Rosa RL; Tian JY; Wright SD; Sparrow CP. 2006. Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype. Biochem Pharmacol 71(4):453-63. PubMed: 16325781MGI: J:105722
- Makoukji J; Shackleford G; Meffre D; Grenier J; Liere P; Lobaccaro JM; Schumacher M; Massaad C. 2011. Interplay between LXR and Wnt/{beta}-Catenin Signaling in the Negative Regulation of Peripheral Myelin Genes by Oxysterols. J Neurosci 31(26):9620-9. PubMed: 21715627MGI: J:174058
- Maqdasy S; El Hajjaji FZ; Baptissart M; Viennois E; Oumeddour A; Brugnon F; Trousson A; Tauveron I; Volle D; Lobaccaro JM; Baron S. 2015. Identification of the Functions of Liver X Receptor-beta in Sertoli Cells Using a Targeted Expression-Rescue Model. Endocrinology 156(12):4545-57. PubMed: 26402841MGI: J:232749
- Marmugi A; Lukowicz C; Lasserre F; Montagner A; Polizzi A; Ducheix S; Goron A; Gamet-Payrastre L; Gerbal-Chaloin S; Pascussi JM; Moldes M; Pineau T; Guillou H; Mselli-Lakhal L. 2016. Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way. Toxicol Appl Pharmacol 303:90-100. PubMed: 27180240MGI: J:234473
- Martin LJ; Tremblay JJ. 2010. Nuclear receptors in leydig cell gene expression and function. Biol Reprod 83(1):3-14. PubMed: 20375256MGI: J:161974
- Menendez-Gutierrez MP; Roszer T; Fuentes L; Nunez V; Escolano A; Redondo JM; De Clerck N; Metzger D; Valledor AF; Ricote M. 2015. Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling. J Clin Invest 125(2):809-23. PubMed: 25574839MGI: J:220393
- Mouzat K; Prod'homme M; Volle DH; Sion B; Dechelotte P; Gauthier K; Vanacker JM; Lobaccaro JM. 2007. Oxysterol nuclear receptor LXRbeta regulates cholesterol homeostasis and contractile function in mouse uterus. J Biol Chem 282(7):4693-701. PubMed: 17166844MGI: J:120923
- Mouzat K; Volat F; Baron S; Alves G; Pommier AJ; Volle DH; Marceau G; DeHaze A; Dechelotte P; Duggavathi R; Caira F; Lobaccaro JM. 2009. Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice. Endocrinology 150(7):3369-75. PubMed: 19325005MGI: J:158168
- Oumeddour A; Viennois E; Caira F; Decourbey C; Maqdasy S; Tahraoui A; Baron S; Volle DH; Lobaccaro JM. 2014. Liver X receptors interfere with the deleterious effect of diethylstilbestrol on testicular physiology. Biochem Biophys Res Commun 446(3):656-62. PubMed: 24333430MGI: J:219158
- Ouvrier A; Alves G; Damon-Soubeyrand C; Marceau G; Cadet R; Janny L; Brugnon F; Kocer A; Pommier A; Lobaccaro JM; Drevet JR; Saez F. 2011. Dietary cholesterol-induced post-testicular infertility. PLoS One 6(11):e26966. PubMed: 22073227MGI: J:180996
- Ouvrier A; Cadet R; Vernet P; Lallier B; Chardigny JM; Lobaccaro JM; Drevet JR; Saez F. 2009. LXR and ABCA1 control cholesterol homeostasis in the proximal mouse epididymis in a cell specific manner. J Lipid Res 50:1766-1775. PubMed: 19395734MGI: J:153781
- Pascual-Garcia M; Carbo JM; Leon T; Matalonga J; Out R; Van Berkel T; Sarrias MR; Lozano F; Celada A; Valledor AF. 2011. Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4. J Immunol 186(8):4656-67. PubMed: 21398609MGI: J:172455
- Pascual-Garcia M; Rue L; Leon T; Julve J; Carbo JM; Matalonga J; Auer H; Celada A; Escola-Gil JC; Steffensen KR; Perez-Navarro E; Valledor AF. 2013. Reciprocal negative cross-talk between liver X receptors (LXRs) and STAT1: effects on IFN-gamma-induced inflammatory responses and LXR-dependent gene expression. J Immunol 190(12):6520-32. PubMed: 23686490MGI: J:204840
- Patel M; Wang XX; Magomedova L; John R; Rasheed A; Santamaria H; Wang W; Tsai R; Qiu L; Orellana A; Advani A; Levi M; Cummins CL. 2014. Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice. Diabetologia 57(2):435-46. PubMed: 24201575MGI: J:208095
- Patel R; Patel M; Tsai R; Lin V; Bookout AL; Zhang Y; Magomedova L; Li T; Chan JF; Budd C; Mangelsdorf DJ; Cummins CL. 2011. LXRbeta is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice. J Clin Invest 121(1):431-41. PubMed: 21123945MGI: J:171854
- Pommier AJ; Dufour J; Alves G; Viennois E; De Boussac H; Trousson A; Volle DH; Caira F; Val P; Arnaud P; Lobaccaro JM; Baron S. 2013. Liver x receptors protect from development of prostatic intra-epithelial neoplasia in mice. PLoS Genet 9(5):e1003483. PubMed: 23675307MGI: J:197130
- Repa JJ; Berge KE; Pomajzl C; Richardson JA; Hobbs H; Mangelsdorf DJ. 2002. Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem 277(21):18793-800. PubMed: 11901146MGI: J:76837
- Repa JJ; Liang G; Ou J; Bashmakov Y; Lobaccaro JM; Shimomura I; Shan B; Brown MS; Goldstein JL; Mangelsdorf DJ. 2000. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta Genes Dev 14(22):2819-30. PubMed: 11090130MGI: J:65994
- Repa JJ; Turley SD; Lobaccaro JA; Medina J; Li L; Lustig K; Shan B; Heyman RA; Dietschy JM; Mangelsdorf DJ. 2000. Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers [see comments] Science 289(5484):1524-9. PubMed: 10968783MGI: J:64343
- Rong X; Albert CJ; Hong C; Duerr MA; Chamberlain BT; Tarling EJ; Ito A; Gao J; Wang B; Edwards PA; Jung ME; Ford DA; Tontonoz P. 2013. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metab 18(5):685-97. PubMed: 24206663MGI: J:206173
- Sallam T; Ito A; Rong X; Kim J; van Stijn C; Chamberlain BT; Jung ME; Chao LC; Jones M; Gilliland T; Wu X; Su GL; Tangirala RK; Tontonoz P; Hong C. 2014. The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis. J Lipid Res 55(6):1120-1130. PubMed: 24671012MGI: J:212418
- Silvennoinen R; Escola-Gil JC; Julve J; Rotllan N; Llaverias G; Metso J; Valledor AF; He J; Yu L; Jauhiainen M; Blanco-Vaca F; Kovanen PT; Lee-Rueckert M. 2012. Acute psychological stress accelerates reverse cholesterol transport via corticosterone-dependent inhibition of intestinal cholesterol absorption. Circ Res 111(11):1459-69. PubMed: 22931956MGI: J:212624
- Spann NJ; Garmire LX; McDonald JG; Myers DS; Milne SB; Shibata N; Reichart D; Fox JN; Shaked I; Heudobler D; Raetz CR; Wang EW; Kelly SL; Sullards MC; Murphy RC; Merrill AH Jr; Brown HA; Dennis EA; Li AC; Ley K; Tsimikas S; Fahy E; Subramaniam S; Quehenberger O; Russell DW; Glass CK. 2012. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell 151(1):138-52. PubMed: 23021221MGI: J:188262
- Tangirala RK; Bischoff ED; Joseph SB; Wagner BL; Walczak R; Laffitte BA; Daige CL; Thomas D; Heyman RA; Mangelsdorf DJ; Wang X; Lusis AJ; Tontonoz P; Schulman IG. 2002. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A 99(18):11896-901. PubMed: 12193651MGI: J:125452
- Tian J; Goldstein JL; Brown MS. 2016. Insulin induction of SREBP-1c in rodent liver requires LXRalpha-C/EBPbeta complex. Proc Natl Acad Sci U S A 113(29):8182-7. PubMed: 27382175MGI: J:234400
- Uemura A; Kusuhara S; Wiegand SJ; Yu RT; Nishikawa S. 2006. Tlx acts as a proangiogenic switch by regulating extracellular assembly of fibronectin matrices in retinal astrocytes. J Clin Invest 116(2):369-77. PubMed: 16424942MGI: J:105463
- Umetani M; Domoto H; Gormley AK; Yuhanna IS; Cummins CL; Javitt NB; Korach KS; Shaul PW; Mangelsdorf DJ. 2007. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat Med 13(10):1185-92. PubMed: 17873880MGI: J:129931
- Uppal H; Saini SP; Moschetta A; Mu Y; Zhou J; Gong H; Zhai Y; Ren S; Michalopoulos GK; Mangelsdorf DJ; Xie W. 2007. Activation of LXRs prevents bile acid toxicity and cholestasis in female mice. Hepatology 45(2):422-32. PubMed: 17256725MGI: J:136468
- Valasek MA; Clarke SL; Repa JJ. 2007. Fenofibrate reduces intestinal cholesterol absorption via PPARalpha-dependent modulation of NPC1L1 expression in mouse. J Lipid Res 48(12):2725-35. PubMed: 17726195MGI: J:129975
- Valbuena-Diez AC; Blanco FJ; Oujo B; Langa C; Gonzalez-Nunez M; Llano E; Pendas AM; Diaz M; Castrillo A; Lopez-Novoa JM; Bernabeu C. 2012. Oxysterol-induced soluble endoglin release and its involvement in hypertension. Circulation 126(22):2612-24. PubMed: 23110859MGI: J:210146
- Viennois E; Esposito T; Dufour J; Pommier A; Fabre S; Kemeny JL; Guy L; Morel L; Lobaccaro JM; Baron S. 2012. Lxralpha regulates the androgen response in prostate epithelium. Endocrinology 153(7):3211-23. PubMed: 22547570MGI: J:188637
- Volle DH; Mouzat K; Duggavathi R; Siddeek B; Dechelotte P; Sion B; Veyssiere G; Benahmed M; Lobaccaro JM. 2007. Multiple roles of the nuclear receptors for oxysterols liver X receptor to maintain male fertility. Mol Endocrinol 21(5):1014-27. PubMed: 17341595MGI: J:120913
- Volle DH; Repa JJ; Mazur A; Cummins CL; Val P; Henry-Berger J; Caira F; Veyssiere G; Mangelsdorf DJ; Lobaccaro JM. 2004. Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Mol Endocrinol 18(4):888-98. PubMed: 14739254MGI: J:89079
- Wang H; Zhang Y; Yehuda-Shnaidman E; Medvedev AV; Kumar N; Daniel KW; Robidoux J; Czech MP; Mangelsdorf DJ; Collins S. 2008. Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype. Mol Cell Biol 28(7):2187-200. PubMed: 18195045MGI: J:134191
- Watanabe M; Houten SM; Wang L; Moschetta A; Mangelsdorf DJ; Heyman RA; Moore DD; Auwerx J. 2004. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest 113(10):1408-18. PubMed: 15146238MGI: J:120199
- Whitfield M; Ouvrier A; Cadet R; Damon-Soubeyrand C; Guiton R; Janny L; Kocer A; Marceau G; Pons-Rejraji H; Trousson A; Drevet JR; Saez F. 2016. Liver X Receptors (LXRs) Alpha and Beta Play Distinct Roles in the Mouse Epididymis. Biol Reprod 94(3):55. PubMed: 26792941MGI: J:232442
- Wu S; Yin R; Ernest R; Li Y; Zhelyabovska O; Luo J; Yang Y; Yang Q. 2009. Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF-kappaB signalling. Cardiovasc Res 84(1):119-26. PubMed: 19487338MGI: J:172488
- Zelcer N; Khanlou N; Clare R; Jiang Q; Reed-Geaghan EG; Landreth GE; Vinters HV; Tontonoz P. 2007. Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors. Proc Natl Acad Sci U S A 104(25):10601-6. PubMed: 17563384MGI: J:122372
- Zhao Z; Xu D; Li S; He B; Huang Y; Xu M; Ren S; Li S; Wang H; Xie W. 2016. Activation of Liver X Receptor Attenuates Oleic Acid-Induced Acute Respiratory Distress Syndrome. Am J Pathol 186(10):2614-22. PubMed: 27520356MGI: J:235602