STOCK Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}/J

Stock No:: 013731 |; R26R-Confetti

Repository Live

Overview

Also Known As: R26R-Brainbow2.1, R26R-Confetti

R26R-Confetti mice are available on a congenic C57BL/6J background (Stock No. 017492) and that congenic version will replace this mixed background strain in the near future.

The R26R-Confetti conditional allele has a CAG promoter followed by a floxed-STOP cassette and the Brainbow 2.1 construct all targeted into the Gt(ROSA)26Sor locus. The R26R-Confetti allele functions as a stochastic multicolor Cre recombinase reporter of multiple fluorescent proteins from a single genomic locus. These R26R-Confetti mice allow a way to label and distinguish individual / adjacent cells with nuclear localized, membrane-targeted, or cytoplasmic fluorescent proteins in cre recombined cells.

Donating Investigator

Hans Clevers, Hubrecht Institute

Genetic overview

Genetic Background	Generation
	F?+F17 (2017-07-06 00:00:00)

Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}

Allele Type	Gene Symbol	Gene Name
Targeted (Conditional ready (e.g. floxed), Reporter)	Gt(ROSA)26Sor	gene trap ROSA 26, Philippe Soriano

View Genetics

Research Applications

Research Tools
Neurobiology Research

View All Research Applications

Base Price

Starting at:

$333.00 Domestic price for female

View Price List

Details

Detailed Description

Mice homozygous for the R26R-Confetti conditional allele are viable and fertile, with a CAG promoter, loxP site, and STOP cassette preventing transcription of the downstream Brainbow 2.1 sequences. The Brainbow 2.1 region contains two loxP-flanked dimers, each uniquely positioned in head-to-tail tandem. One dimer has nuclear-localized green fluorescent protein (hrGFPII) and a reverse-oriented cytoplasmic yellow fluorescent protein (mYFP). The other dimer has cytoplasmic red fluorescent protein (tdimer2(12)) and a reverse-oriented membrane-tethered cyan fluorescent protein (mCerulean). The Brainbow2.1 region may be written as loxP-STOP-loxP-GFP-PFY-Pxol-loxP-RFP-PFC-Pxol to show the transcriptional direction of each part. When bred to mice that express Cre recombinase, the resulting offspring may have a recombination event that stochastically places one of the four fluorescent proteins into position directly downstream of the CAG promoter within the cre-expressing tissues. Because this CAG promoter-driven Brainbow 2.1 reporter construct was targeted for insertion into the Gt(ROSA)26Sor locus, fluorescent protein expression is determined by which tissues express Cre recombinase. The donating investigator reports that mice do not express any fluorescent cells prior to introduction of Cre recombinase. The donating investigator confirms fluorescent protein expression following exposure to cre can be detected by direct fluorescence (and presumably also via mRNA (in situ hybridization) and antibody staining (immunohistochemistry)).

Initial Cre recombination outcomes may recombine the loxP-flanked STOP cassette (green), invert the loxP-STOP-loxP-GFP-PFY-Pxol region (yellow), recombine the loxP-STOP-loxP-GFP-PFY-Pxol-loxP region (red), or invert the entire loxP-STOP-loxP-GFP-PFY-Pxol-loxP-RFP-PFC-Pxol region (blue). Other recombination outcomes may not remove the STOP cassette and result in no fluorescent reporter labeling in cre-expressing cells. In addition, sequential recombination outcomes may reduce the construct to a single invertible dimer segment that can continue to invert as long as Cre recombinase is present. The donating investigator also reports that weaker cre expression favors inverting the loxP-STOP-loxP-GFP-PFY-Pxol region rather than removal of the loxP-STOP-loxP region: this results in less green-fluorescing cells / more non-fluorescing cells than is expected if using a strong cre-expressing line.

View R26R-Confetti images [pdf]

Development

A targeting vector containing (from 5' to 3') a strong CAGG promoter (CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter), a loxP site, a PGK-Neo^r-pA cassette (serving as a transcriptional roadblock), and the Brainbow 2.1 construct (described in greater detail below). This entire construct was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus via electroporation into 129P2/OlaHsd-derived IB10/E14IB10 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric males were bred with C57BL/6 females to generate the R26R-Confetti colony. The resulting R26R-Confetti colony were bred with other mutant or cre-expressing mice, but these other mutations were bred away from the R26R-Confetti colony. The R26R-Confetti mice are reported to be on a genetic background equivalent to ~2-3 backcross generations to C57BL/6 prior to sending to The Jackson Laboratory Repository in 2010. Upon arrival the mice were bred with C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony.

The Brainbow 2.1 construct was designed by Drs. Jeff Lichtman and Joshua Sanes (Harvard University) with four fluorescent protein sequences uniquely positioned in a tandem fashion and delimited by loxP sites in opposite orientation. Specifically, this Brainbow 2.1 coding region is composed of two adjacent floxed head-to-tail tandem dimers. The first head-to-tail dimer contains a loxP site and humanized Renilla GFP (hrGFPII; with nuclear localization signal plus polyA sequence) in forward orientation, and a loxP site and monomeric EYFP (mYFP^A206K plus polyA sequence) in reverse orientation. The second head-to-tail dimer contains a loxP site and tdimer2(12) RFP plus polyA sequence in forward orientation, and a loxP site and mCerulean CFP (with membrane tethering palmitoylation sequence plus polyA sequence) in reverse orientation. A single frt site is located at the 3' end of the Brainbow 2.1 construct. The entire construct may be written as loxP-STOP-loxP-GFP-PFY-Pxol-loxP-RFP-PFC-Pxol-frt to show transcriptional direction of each part.

The hrGFPII variant of GFP (from Stratagene vector phrGFPII-C) has amino acid substitutions designed to improve spectral properties and performance in mammalian systems. The monomeric EYFP (mYFP^A206K) has an amino acid substitution replacing a hydrophobic region with a positively charged residue designed to prevent dimerization. The tdimer2(12) RFP is a non-oligomerizing DsRed variant with a 12 residue linker fusing two copies of the protein (tandem dimer). The monomeric Cerulean (mCerulean) is a variant of ECFP (ECFP^{S72A/Y145A/H148D/A206K}) with amino acid substitutions designed to improve spectral properties and prevent dimerization.

Expression Data

Expressed Gene	CFP, Cyan Fluorescent Protein, jellyfish
Expressed Gene	GFP, Green Fluorescent Protein,
Expressed Gene	YFP, Yellow Fluorescent Protein, jellyfish
Expressed Gene	RFP, Red Fluorescent Protein, coral
Site of Expression	Cre recombination results in stochastic multicolor fluorescent proteins being expressed from a single genomic locus in cre-expressing tissues.

Control Suggestions

Approximate Controls

000664 C57BL/6J, ()

Additional Information

Considerations for Choosing Controls

Selected References

Livet J; Weissman TA; Kang H; Draft RW; Lu J; Bennis RA; Sanes JR; Lichtman JW. 2007. Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. (7166): 56-62. PubMed: 17972876 MGI: 127053
Snippert HJ; van der Flier LG; Sato T; van Es JH; van den Born M; Kroon-Veenboer C; Barker N; Klein AM; van Rheenen J; Simons BD; Clevers H. 2010. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. (1): 134-44. PubMed: 20887898 MGI: 165740

View All References

Genetics

Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}

Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}

Allele Name	targeted mutation 1, Hans Clevers
Allele Type	Targeted (Conditional ready (e.g. floxed), Reporter)
Allele Synonym(s)	R26R-Brainbow2.1; R26R-Confetti
Gene Symbol and Name	Gt(ROSA)26Sor, gene trap ROSA 26, Philippe Soriano
Gene Synonym(s)	beta geo; ROSA26; R26; Gtrgeo26; Gtrosa26; Gtrgeo26; Gtrosa26; AV258896; expressed sequence AV258896; gene trap ROSA 26; gene trap ROSA b-geo 26; SETD5-AS1; Thumpd3as1
Expressed Gene	CFP, Cyan Fluorescent Protein, jellyfish
Expressed Gene	GFP, Green Fluorescent Protein,
Expressed Gene	YFP, Yellow Fluorescent Protein, jellyfish
Expressed Gene	RFP, Red Fluorescent Protein, coral
Site of Expression	Cre recombination results in stochastic multicolor fluorescent proteins being expressed from a single genomic locus in cre-expressing tissues.
Strain of Origin	129P2/OlaHsd
Chromosome	6
Molecular Note	A targeting vector containing (from 5' to 3') a strong CAGG promoter, a loxP site, a PGK-Neo-pA cassette (serving as a transcriptional roadblock), and the Brainbow 2.1 construct. This entire construct was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus. The Brainbow 2.1 construct was designed by Drs. Jeff Lichtman and Joshua Sanes (Harvard University) with four fluorescent protein sequences uniquely positioned in a tandem fashion and delimited by loxP sites in opposite orientation. Specifically, this Brainbow 2.1 coding region is composed of two adjacent floxed head-to-tail tandem dimers. The first head-to-tail dimer contains a loxP site and humanized Renilla GFP (hrGFPII; with nuclear localization signal plus polyA sequence) in forward orientation and a loxP site and monomeric EYFP (mYFPA206K plus polyA sequence) in reverse orientation. The second head-to-tail dimer contains a loxP site and tdimer2(12) RFP plus polyA sequence in forward orientation, and a loxP site and mCerulean CFP (with membrane tethering palmitoylation sequence plus polyA sequence) in reverse orientation. A single frt site is located at the 3' end of the Brainbow 2.1 construct.
Mutations Made By	Hans Clevers, Hubrecht Institute

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: GFP related

Research Tools
- Fluorescent Proteins

Genotype: YFP related

Research Tools
- Fluorescent Proteins

Research Tools
- Toxicology Research
  - xenograft/transplant host
  - B and T cell deficiency, xenograft transplant host
- Genetics Research
  - Mutagenesis and Transgenesis
  - Mutagenesis and Transgenesis: Cre-lox System
  - Tissue/Cell Markers
  - Tissue/Cell Markers: cell marker for bone marrow transplantation
  - Tissue/Cell Markers: Cre-lox System
  - Tissue/Cell Markers: spermatogonial transplantation marker
  - Tissue/Cell Markers: transplantation marker for embryonic and adult tissue
- Reproductive Biology Research
  - Cre-lox System
  - spermatogonial transplantation marker
  - transplantation marker for embryonic and adult tissue
- Neurobiology Research
  - cell marker
- Cre-lox System
  - loxP-flanked Sequences
  - loxP-flanked Sequences: Test/Reporter
- Developmental Biology Research
  - transplantation marker for embryonic and adult tissue
  - Cre-lox System
- Fluorescent Proteins
- Cardiovascular Research
  - Cre-lox System
- Immunology, Inflammation and Autoimmunity Research
  - T cell deficiency, xenograft/transplant host
Neurobiology Research
- Fluorescent protein expression in neural tissue
- Cre-lox System
  - loxP-flanked Sequences
  - loxP-flanked Sequences: Test/Reporter

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}/Gt(ROSA)26Sor⁺
involves: 129P2/OlaHsd

no phenotypic analysis

no phenotypic analysis

References

Livet J; Weissman TA; Kang H; Draft RW; Lu J; Bennis RA; Sanes JR; Lichtman JW. 2007. Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. (7166): 56-62. PubMed: 17972876 MGI: 127053
Snippert HJ; van der Flier LG; Sato T; van Es JH; van den Born M; Kroon-Veenboer C; Barker N; Klein AM; van Rheenen J; Simons BD; Clevers H. 2010. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. (1): 134-44. PubMed: 20887898 MGI: 165740

Additional - Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}

van Es JH; Sato T; van de Wetering M; Lyubimova A; Nee AN; Gregorieff A; Sasaki N; Zeinstra L; van den Born M; Korving J; Martens AC; Barker N; van Oudenaarden A; Clevers H. 2012. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage. (10): 1099-104. PubMed: 23000963 MGI: 195033
Sato T; van Es JH; Snippert HJ; Stange DE; Vries RG; van den Born M; Barker N; Shroyer NF; van de Wetering M; Clevers H. 2011. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. (7330): 415-8. PubMed: 21113151 MGI: 169824
Li J; Miao L; Shieh D; Spiotto E; Li J; Zhou B; Paul A; Schwartz RJ; Firulli AB; Singer HA; Huang G; Wu M. 2016. Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification. (1): 158-70. PubMed: 27052172 MGI: 236175
Yan KS; Chia LA; Li X; Ootani A; Su J; Lee JY; Su N; Luo Y; Heilshorn SC; Amieva MR; Sangiorgi E; Capecchi MR; Kuo CJ. 2012. The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations. (2): 466-71. PubMed: 22190486 MGI: 181090
Schepers AG; Snippert HJ; Stange DE; van den Born M; van Es JH; van de Wetering M; Clevers H. 2012. Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. (6095): 730-5. PubMed: 22855427 MGI: 187726
Goldmann T; Zeller N; Raasch J; Kierdorf K; Frenzel K; Ketscher L; Basters A; Staszewski O; Brendecke SM; Spiess A; Tay TL; Kreutz C; Timmer J; Mancini GM; Blank T; Fritz G; Biber K; Lang R; Malo D; Merkler D; Heikenwalder M; Knobeloch KP; Prinz M. 2015. USP18 lack in microglia causes destructive interferonopathy of the mouse brain. (12): 1612-29. PubMed: 25896511 MGI: 223711
Urban N; van den Berg DL; Forget A; Andersen J; Demmers JA; Hunt C; Ayrault O; Guillemot F. 2016. Return to quiescence of mouse neural stem cells by degradation of a proactivation protein. (6296): 292-5. PubMed: 27418510 MGI: 234912
Wang L; Benedito R; Bixel MG; Zeuschner D; Stehling M; Savendahl L; Haigh JJ; Snippert H; Clevers H; Breier G; Kiefer F; Adams RH. 2013. Identification of a clonally expanding haematopoietic compartment in bone marrow. (2): 219-30. PubMed: 23188081 MGI: 194220
Chen H; Matsumoto K; Brockway BL; Rackley CR; Liang J; Lee JH; Jiang D; Noble PW; Randell SH; Kim CF; Stripp BR. 2012. Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. (9): 1948-60. PubMed: 22696116 MGI: 195751
Tanaka T; Komai Y; Tokuyama Y; Yanai H; Ohe S; Okazaki K; Ueno H. 2013. Identification of stem cells that maintain and regenerate lingual keratinized epithelial cells. (5): 511-8. PubMed: 23563490 MGI: 198785
Barkauskas CE; Cronce MJ; Rackley CR; Bowie EJ; Keene DR; Stripp BR; Randell SH; Noble PW; Hogan BL. 2013. Type 2 alveolar cells are stem cells in adult lung. (7): 3025-36. PubMed: 23921127 MGI: 202722
Glenn ST; Jones CA; Sexton S; LeVea CM; Caraker SM; Hajduczok G; Gross KW. 2014. Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma. (50): 5706-15. PubMed: 24292676 MGI: 217656
Leushacke M; Ng A; Galle J; Loeffler M; Barker N. 2013. Lgr5(+) gastric stem cells divide symmetrically to effect epithelial homeostasis in the pylorus. (2): 349-56. PubMed: 24209744 MGI: 206228
Peng T; Tian Y; Boogerd CJ; Lu MM; Kadzik RS; Stewart KM; Evans SM; Morrisey EE. 2013. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. (7464): 589-92. PubMed: 23873040 MGI: 205840
Choi YS; Zhang Y; Xu M; Yang Y; Ito M; Peng T; Cui Z; Nagy A; Hadjantonakis AK; Lang RA; Cotsarelis G; Andl T; Morrisey EE; Millar SE. 2013. Distinct Functions for Wnt/beta-Catenin in Hair Follicle Stem Cell Proliferation and Survival and Interfollicular Epidermal Homeostasis. (6): 720-33. PubMed: 24315444 MGI: 205239
Fischer JM; Schepers AG; Clevers H; Shibata D; Liskay RM. 2014. Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. (1): 237-46. PubMed: 23996931 MGI: 205631
Hackl MJ; Burford JL; Villanueva K; Lam L; Susztak K; Schermer B; Benzing T; Peti-Peterdi J. 2013. Tracking the fate of glomerular epithelial cells in vivo using serial multiphoton imaging in new mouse models with fluorescent lineage tags. (12): 1661-6. PubMed: 24270544 MGI: 207940
Uchida S; De Gaspari P; Kostin S; Jenniches K; Kilic A; Izumiya Y; Shiojima I; Grosse Kreymborg K; Renz H; Walsh K; Braun T. 2013. Sca1-derived cells are a source of myocardial renewal in the murine adult heart. (5): 397-410. PubMed: 24286028 MGI: 207242
Rios AC; Fu NY; Lindeman GJ; Visvader JE. 2014. In situ identification of bipotent stem cells in the mammary gland. (7488): 322-7. PubMed: 24463516 MGI: 208058
Desai TJ; Brownfield DG; Krasnow MA. 2014. Alveolar progenitor and stem cells in lung development, renewal and cancer. (7491): 190-4. PubMed: 24499815 MGI: 208565
Li L; Ginty DD. 2014. The structure and organization of lanceolate mechanosensory complexes at mouse hair follicles. e01901. PubMed: 24569481 MGI: 209064
Sutherland KD; Song JY; Kwon MC; Proost N; Zevenhoven J; Berns A. 2014. Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma. (13): 4952-7. PubMed: 24586047 MGI: 208493
Ritsma L; Ellenbroek SI; Zomer A; Snippert HJ; de Sauvage FJ; Simons BD; Clevers H; van Rheenen J. 2014. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. (7492): 362-5. PubMed: 24531760 MGI: 209856
Zhu Z; Khan MA; Weiler M; Blaes J; Jestaedt L; Geibert M; Zou P; Gronych J; Bernhardt O; Korshunov A; Bugner V; Lichter P; Radlwimmer B; Heiland S; Bendszus M; Wick W; Liu HK. 2014. Targeting self-renewal in high-grade brain tumors leads to loss of brain tumor stem cells and prolonged survival. (2): 185-98. PubMed: 24835569 MGI: 212350
Guo C; Eckler MJ; McKenna WL; McKinsey GL; Rubenstein JL; Chen B. 2013. Fezf2 expression identifies a multipotent progenitor for neocortical projection neurons, astrocytes, and oligodendrocytes. (5): 1167-74. PubMed: 24314728 MGI: 208257
Snippert HJ; Schepers AG; van Es JH; Simons BD; Clevers H. 2014. Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. (1): 62-9. PubMed: 24355609 MGI: 213062
Fioret BA; Heimfeld JD; Paik DT; Hatzopoulos AK. 2014. Endothelial Cells Contribute to Generation of Adult Ventricular Myocytes during Cardiac Homeostasis. (1): 229-41. PubMed: 25001281 MGI: 213168
Dyachuk V; Furlan A; Shahidi MK; Giovenco M; Kaukua N; Konstantinidou C; Pachnis V; Memic F; Marklund U; Muller T; Birchmeier C; Fried K; Ernfors P; Adameyko I. 2014. Neurodevelopment. Parasympathetic neurons originate from nerve-associated peripheral glial progenitors. (6192): 82-7. PubMed: 24925909 MGI: 212799
Worthley DL; Churchill M; Compton JT; Tailor Y; Rao M; Si Y; Levin D; Schwartz MG; Uygur A; Hayakawa Y; Gross S; Renz BW; Setlik W; Martinez AN; Chen X; Nizami S; Lee HG; Kang HP; Caldwell JM; Asfaha S; Westphalen CB; Graham T; Jin G; Nagar K; Wang H; Kheirbek MA; Kolhe A; Carpenter J; Glaire M; Nair A; Renders S; Manieri N; Muthupalani S; Fox JG; Reichert M; Giraud AS; Schwabe RF; Pradere JP; Walton K; Prakash A; Gumucio D; Rustgi AK; Stappenbeck TS; Friedman RA; Gershon MD; Sims P; Grikscheit T; Lee FY;. 2015. Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential. (1-2): 269-84. PubMed: 25594183 MGI: 220425
Tian X; Hu T; Zhang H; He L; Huang X; Liu Q; Yu W; He L; Yang Z; Zhang Z; Zhong TP; Yang X; Yang Z; Yan Y; Baldini A; Sun Y; Lu J; Schwartz RJ; Evans SM; Gittenberger-de Groot AC; Red-Horse K; Zhou B. 2013. Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. (9): 1075-90. PubMed: 23797856 MGI: 222054
Lescroart F; Chabab S; Lin X; Rulands S; Paulissen C; Rodolosse A; Auer H; Achouri Y; Dubois C; Bondue A; Simons BD; Blanpain C. 2014. Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development. (9): 829-40. PubMed: 25150979 MGI: 220481
Murphy PA; Kim TN; Huang L; Nielsen CM; Lawton MT; Adams RH; Schaffer CB; Wang RA. 2014. Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels. (50): 18007-12. PubMed: 25468970 MGI: 218908
Kaukua N; Shahidi MK; Konstantinidou C; Dyachuk V; Kaucka M; Furlan A; An Z; Wang L; Hultman I; Ahrlund-Richter L; Blom H; Brismar H; Lopes NA; Pachnis V; Suter U; Clevers H; Thesleff I; Sharpe P; Ernfors P; Fried K; Adameyko I. 2014. Glial origin of mesenchymal stem cells in a tooth model system. (7519): 551-4. PubMed: 25079316 MGI: 218195
Parmigiani E; Leto K; Rolando C; Figueres-Onate M; Lopez-Mascaraque L; Buffo A; Rossi F. 2015. Heterogeneity and Bipotency of Astroglial-Like Cerebellar Progenitors along the Interneuron and Glial Lineages. (19): 7388-402. PubMed: 25972168 MGI: 222735
Watson JK; Rulands S; Wilkinson AC; Wuidart A; Ousset M; Van Keymeulen A; Gottgens B; Blanpain C; Simons BD; Rawlins EL. 2015. Clonal Dynamics Reveal Two Distinct Populations of Basal Cells in Slow-Turnover Airway Epithelium. (1): 90-101. PubMed: 26119728 MGI: 225953
Sun GJ; Zhou Y; Stadel RP; Moss J; Yong JH; Ito S; Kawasaki NK; Phan AT; Oh JH; Modak N; Reed RR; Toni N; Song H; Ming GL. 2015. Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain. (30): 9484-9. PubMed: 26170290 MGI: 227073
Dyment NA; Breidenbach AP; Schwartz AG; Russell RP; Aschbacher-Smith L; Liu H; Hagiwara Y; Jiang R; Thomopoulos S; Butler DL; Rowe DW. 2015. Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis. (1): 96-107. PubMed: 26141957 MGI: 226924
Mo Y; Chen J; Humphrey DM Jr; Fodah RA; Warawa JM; Hoyle GW. 2015. Abnormal epithelial structure and chronic lung inflammation after repair of chlorine-induced airway injury. (2): L168-78. PubMed: 25398987 MGI: 228894
Hayakawa Y; Ariyama H; Stancikova J; Sakitani K; Asfaha S; Renz BW; Dubeykovskaya ZA; Shibata W; Wang H; Westphalen CB; Chen X; Takemoto Y; Kim W; Khurana SS; Tailor Y; Nagar K; Tomita H; Hara A; Sepulveda AR; Setlik W; Gershon MD; Saha S; Ding L; Shen Z; Fox JG; Friedman RA; Konieczny SF; Worthley DL; Korinek V; Wang TC. 2015. Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. (6): 800-14. PubMed: 26585400 MGI: 228347
Demitrack ES; Gifford GB; Keeley TM; Carulli AJ; VanDussen KL; Thomas D; Giordano TJ; Liu Z; Kopan R; Samuelson LC. 2015. Notch signaling regulates gastric antral LGR5 stem cell function. (20): 2522-36. PubMed: 26271103 MGI: 227727
Yahalom-Ronen Y; Rajchman D; Sarig R; Geiger B; Tzahor E. 2015. Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion. . PubMed: 26267307 MGI: 227732
Maddipati R; Stanger BZ. 2015. Pancreatic Cancer Metastases Harbor Evidence of Polyclonality. (10): 1086-97. PubMed: 26209539 MGI: 231701
Cheung KJ; Padmanaban V; Silvestri V; Schipper K; Cohen JD; Fairchild AN; Gorin MA; Verdone JE; Pienta KJ; Bader JS; Ewald AJ. 2016. Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. (7): E854-63. PubMed: 26831077 MGI: 231532
Wuidart A; Ousset M; Rulands S; Simons BD; Van Keymeulen A; Blanpain C. 2016. Quantitative lineage tracing strategies to resolve multipotency in tissue-specific stem cells. (11): 1261-77. PubMed: 27284162 MGI: 234402
Feil S; Fehrenbacher B; Lukowski R; Essmann F; Schulze-Osthoff K; Schaller M; Feil R. 2014. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. (7): 662-7. PubMed: 25070003 MGI: 235990
Hayakawa Y; Sakitani K; Konishi M; Asfaha S; Niikura R; Tomita H; Renz BW; Tailor Y; Macchini M; Middelhoff M; Jiang Z; Tanaka T; Dubeykovskaya ZA; Kim W; Chen X; Urbanska AM; Nagar K; Westphalen CB; Quante M; Lin CS; Gershon MD; Hara A; Zhao CM; Chen D; Worthley DL; Koike K; Wang TC. 2017. Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling. (1): 21-34. PubMed: 27989802 MGI: 239512
Wang AB; Zhang YV; Tumbar T. 2017. Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation. (1): 61-78. PubMed: 27908934 MGI: 240177
Aure MH; Konieczny SF; Ovitt CE. 2015. Salivary gland homeostasis is maintained through acinar cell self-duplication. (2): 231-7. PubMed: 25843887 MGI: 240378
Maruyama T; Jeong J; Sheu TJ; Hsu W. 2016. Stem cells of the suture mesenchyme in craniofacial bone development, repair and regeneration. 10526. PubMed: 26830436 MGI: 237384
Xie T; Liang J; Liu N; Huan C; Zhang Y; Liu W; Kumar M; Xiao R; D'Armiento J; Metzger D; Chambon P; Papaioannou VE; Stripp BR; Jiang D; Noble PW. 2016. Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis. (8): 3063-79. PubMed: 27400124 MGI: 238220
McConnell AM; Yao C; Yeckes AR; Wang Y; Selvaggio AS; Tang J; Kirsch DG; Stripp BR. 2016. p53 Regulates Progenitor Cell Quiescence and Differentiation in the Airway. (9): 2173-2182. PubMed: 27880895 MGI: 242335
Frank DB; Peng T; Zepp JA; Snitow M; Vincent TL; Penkala IJ; Cui Z; Herriges MJ; Morley MP; Zhou S; Lu MM; Morrisey EE. 2016. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. (9): 2312-2325. PubMed: 27880906 MGI: 242329
Yang H; Adam RC; Ge Y; Hua ZL; Fuchs E. 2017. Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices. (3): 483-496.e13. PubMed: 28413068 MGI: 242600
Prochazka J; Prochazkova M; Du W; Spoutil F; Tureckova J; Hoch R; Shimogori T; Sedlacek R; Rubenstein JL; Wittmann T; Klein OD. 2015. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. (6): 713-24. PubMed: 26702830 MGI: 241082
Singh SP; LaSarge CL; An A; McAuliffe JJ; Danzer SC. 2015. Clonal Analysis of Newborn Hippocampal Dentate Granule Cell Proliferation and Development in Temporal Lobe Epilepsy. (6): . PubMed: 26756038 MGI: 241065
Xu M; Horrell J; Snitow M; Cui J; Gochnauer H; Syrett CM; Kallish S; Seykora JT; Liu F; Gaillard D; Katz JP; Kaestner KH; Levin B; Mansfield C; Douglas JE; Cowart BJ; Tordoff M; Liu F; Zhu X; Barlow LA; Rubin AI; McGrath JA; Morrisey EE; Chu EY; Millar SE. 2017. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. 15397. PubMed: 28589954 MGI: 243288
Yuan D; Huang S; Berger E; Liu L; Gross N; Heinzmann F; Ringelhan M; Connor TO; Stadler M; Meister M; Weber J; Ollinger R; Simonavicius N; Reisinger F; Hartmann D; Meyer R; Reich M; Seehawer M; Leone V; Hochst B; Wohlleber D; Jors S; Prinz M; Spalding D; Protzer U; Luedde T; Terracciano L; Matter M; Longerich T; Knolle P; Ried T; Keitel V; Geisler F; Unger K; Cinnamon E; Pikarsky E; Huser N; Davis RJ; Tschaharganeh DF; Rad R; Weber A; Zender L; Haller D; Heikenwalder M. 2017. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. (6): 771-789.e6. PubMed: 28609656 MGI: 243653
Yoo YA; Roh M; Naseem AF; Lysy B; Desouki MM; Unno K; Abdulkadir SA. 2016. Bmi1 marks distinct castration-resistant luminal progenitor cells competent for prostate regeneration and tumour initiation. 12943. PubMed: 27703144 MGI: 243451
Lasrado R; Boesmans W; Kleinjung J; Pin C; Bell D; Bhaw L; McCallum S; Zong H; Luo L; Clevers H; Vanden Berghe P; Pachnis V. 2017. Lineage-dependent spatial and functional organization of the mammalian enteric nervous system. (6339): 722-726. PubMed: 28522527 MGI: 244808
Decker RS; Um HB; Dyment NA; Cottingham N; Usami Y; Enomoto-Iwamoto M; Kronenberg MS; Maye P; Rowe DW; Koyama E; Pacifici M. 2017. Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs. (1): 56-68. PubMed: 28438606 MGI: 244302
Suarez-Mier GB; Buckwalter MS. 2015. Glial Fibrillary Acidic Protein-Expressing Glia in the Mouse Lung. (5): . PubMed: 26442852 MGI: 245777
Giroux V; Lento AA; Islam M; Pitarresi JR; Kharbanda A; Hamilton KE; Whelan KA; Long A; Rhoades B; Tang Q; Nakagawa H; Lengner CJ; Bass AJ; Wileyto EP; Klein-Szanto AJ; Wang TC; Rustgi AK. 2017. Long-lived keratin 15+ esophageal progenitor cells contribute to homeostasis and regeneration. (6): 2378-2391. PubMed: 28481227 MGI: 245626
Kaverina NV; Kadoya H; Eng DG; Rusiniak ME; Sequeira-Lopez ML; Gomez RA; Pippin JW; Gross KW; Peti-Peterdi J; Shankland SJ. 2017. Tracking the stochastic fate of cells of the renin lineage after podocyte depletion using multicolor reporters and intravital imaging. (3): e0173891. PubMed: 28329012 MGI: 246735
Pitulescu ME; Schmidt I; Giaimo BD; Antoine T; Berkenfeld F; Ferrante F; Park H; Ehling M; Biljes D; Rocha SF; Langen UH; Stehling M; Nagasawa T; Ferrara N; Borggrefe T; Adams RH. 2017. Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. (8): 915-927. PubMed: 28714968 MGI: 252269
Ramasamy SK; Kusumbe AP; Schiller M; Zeuschner D; Bixel MG; Milia C; Gamrekelashvili J; Limbourg A; Medvinsky A; Santoro MM; Limbourg FP; Adams RH. 2016. Blood flow controls bone vascular function and osteogenesis. 13601. PubMed: 27922003 MGI: 244255
Volckaert T; Yuan T; Chao CM; Bell H; Sitaula A; Szimmtenings L; El Agha E; Chanda D; Majka S; Bellusci S; Thannickal VJ; Fassler R; De Langhe SP. 2017. Fgf10-Hippo Epithelial-Mesenchymal Crosstalk Maintains and Recruits Lung Basal Stem Cells. (1): 48-59.e5. PubMed: 29017029 MGI: 247710
Degn SE; van der Poel CE; Firl DJ; Ayoglu B; Al Qureshah FA; Bajic G; Mesin L; Reynaud CA; Weill JC; Utz PJ; Victora GD; Carroll MC. 2017. Clonal Evolution of Autoreactive Germinal Centers. (5): 913-926.e19. PubMed: 28841417 MGI: 258724
Gaertner F; Ahmad Z; Rosenberger G; Fan S; Nicolai L; Busch B; Yavuz G; Luckner M; Ishikawa-Ankerhold H; Hennel R; Benechet A; Lorenz M; Chandraratne S; Schubert I; Helmer S; Striednig B; Stark K; Janko M; Bottcher RT; Verschoor A; Leon C; Gachet C; Gudermann T; Mederos Y Schnitzler M; Pincus Z; Iannacone M; Haas R; Wanner G; Lauber K; Sixt M; Massberg S. 2017. Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria. (6): 1368-1382.e23. PubMed: 29195076 MGI: 264364
Fletcher RB; Das D; Gadye L; Street KN; Baudhuin A; Wagner A; Cole MB; Flores Q; Choi YG; Yosef N; Purdom E; Dudoit S; Risso D; Ngai J. 2017. Deconstructing Olfactory Stem Cell Trajectories at Single-Cell Resolution. (6): 817-830.e8. PubMed: 28506465 MGI: 264494
Gadye L; Das D; Sanchez MA; Street K; Baudhuin A; Wagner A; Cole MB; Choi YG; Yosef N; Purdom E; Dudoit S; Risso D; Ngai J; Fletcher RB. 2017. Injury Activates Transient Olfactory Stem Cell States with Diverse Lineage Capacities. (6): 775-790.e9. PubMed: 29174333 MGI: 264459
Kohler C; Nittner D; Rambow F; Radaelli E; Stanchi F; Vandamme N; Baggiolini A; Sommer L; Berx G; van den Oord JJ; Gerhardt H; Blanpain C; Marine JC. 2017. Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes. (5): 679-693.e6. PubMed: 29033351 MGI: 264406
Schutgens F; Rookmaaker MB; Blokzijl F; van Boxtel R; Vries R; Cuppen E; Verhaar MC; Clevers H. 2017. Troy/TNFRSF19 marks epithelial progenitor cells during mouse kidney development that continue to contribute to turnover in adult kidney. (52): E11190-E11198. PubMed: 29237753 MGI: 270225
Furlan A; Dyachuk V; Kastriti ME; Calvo-Enrique L; Abdo H; Hadjab S; Chontorotzea T; Akkuratova N; Usoskin D; Kamenev D; Petersen J; Sunadome K; Memic F; Marklund U; Fried K; Topilko P; Lallemend F; Kharchenko PV; Ernfors P; Adameyko I. 2017. Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. (6346): . PubMed: 28684471 MGI: 245686
Kalfon R; Koren L; Aviram S; Schwartz O; Hai T; Aronheim A. 2017. ATF3 expression in cardiomyocytes preserves homeostasis in the heart and controls peripheral glucose tolerance. (2): 134-146. PubMed: 28082453 MGI: 278611
Weng PL; Vinjamuri M; Ovitt CE. 2016. Ascl3 transcription factor marks a distinct progenitor lineage for non-neuronal support cells in the olfactory epithelium. 38199. PubMed: 27910949 MGI: 265292
Kaucka M; Ivashkin E; Gyllborg D; Zikmund T; Tesarova M; Kaiser J; Xie M; Petersen J; Pachnis V; Nicolis SK; Yu T; Sharpe P; Arenas E; Brismar H; Blom H; Clevers H; Suter U; Chagin AS; Fried K; Hellander A; Adameyko I. 2016. Analysis of neural crest-derived clones reveals novel aspects of facial development. (8): e1600060. PubMed: 27493992 MGI: 279661
Ollila S; Domenech-Moreno E; Laajanen K; Wong IP; Tripathi S; Pentinmikko N; Gao Y; Yan Y; Niemela EH; Wang TC; Viollet B; Leone G; Katajisto P; Vaahtomeri K; Makela TP. 2018. Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway. (1): 402-414. PubMed: 29202476 MGI: 276562
Kaucka M; Zikmund T; Tesarova M; Gyllborg D; Hellander A; Jaros J; Kaiser J; Petersen J; Szarowska B; Newton PT; Dyachuk V; Li L; Qian H; Johansson AS; Mishina Y; Currie JD; Tanaka EM; Erickson A; Dudley A; Brismar H; Southam P; Coen E; Chen M; Weinstein LS; Hampl A; Arenas E; Chagin AS; Fried K; Adameyko I. 2017. Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage. . PubMed: 28414273 MGI: 278581
Kabouridis PS; Lasrado R; McCallum S; Chng SH; Snippert HJ; Clevers H; Pettersson S; Pachnis V. 2015. Microbiota controls the homeostasis of glial cells in the gut lamina propria. (2): 289-95. PubMed: 25578362 MGI: 272004
Kuony A; Michon F. 2017. Epithelial Markers aSMA, Krt14, and Krt19 Unveil Elements of Murine Lacrimal Gland Morphogenesis and Maturation. 739. PubMed: 29033846 MGI: 274455
Schaub JR; Huppert KA; Kurial SNT; Hsu BY; Cast AE; Donnelly B; Karns RA; Chen F; Rezvani M; Luu HY; Mattis AN; Rougemont AL; Rosenthal P; Huppert SS; Willenbring H. 2018. De novo formation of the biliary system by TGFbeta-mediated hepatocyte transdifferentiation. (7704): 247-251. PubMed: 29720662 MGI: 285398
Hill RA; Tong L; Yuan P; Murikinati S; Gupta S; Grutzendler J. 2015. Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes. (1): 95-110. PubMed: 26119027 MGI: 271390
Dorner J; Martinez Rodriguez V; Ziegler R; Rohrig T; Cochran RS; Gotz RM; Levin MD; Pihlajoki M; Heikinheimo M; Wilson DB. 2017. GLI1(+) progenitor cells in the adrenal capsule of the adult mouse give rise to heterotopic gonadal-like tissue. 164-175. PubMed: 27585489 MGI: 262079
Zhang Y; Tech L; George LA; Acs A; Durrett RE; Hess H; Walker LSK; Tarlinton DM; Fletcher AL; Hauser AE; Toellner KM. 2018. Plasma cell output from germinal centers is regulated by signals from Tfh and stromal cells. (4): 1227-1243. PubMed: 29549115 MGI: 285574
Kaucka M; Petersen J; Tesarova M; Szarowska B; Kastriti ME; Xie M; Kicheva A; Annusver K; Kasper M; Symmons O; Pan L; Spitz F; Kaiser J; Hovorakova M; Zikmund T; Sunadome K; Matise MP; Wang H; Marklund U; Abdo H; Ernfors P; Maire P; Wurmser M; Chagin AS; Fried K; Adameyko I. 2018. Signals from the brain and olfactory epithelium control shaping of the mammalian nasal capsule cartilage. . PubMed: 29897331 MGI: 290553
Rahmani W; Abbasi S; Hagner A; Raharjo E; Kumar R; Hotta A; Magness S; Metzger D; Biernaskie J. 2014. Hair follicle dermal stem cells regenerate the dermal sheath, repopulate the dermal papilla, and modulate hair type. (5): 543-58. PubMed: 25465495 MGI: 289968

Technical Support

Contact Technical Support

Genotyping Protocols
- Standard PCR: Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}
- Genotyping resources and troubleshooting
Dietary Information
- LabDiet® 5K52 formulation (6% fat)
Breeding Considerations

When maintaining a live colony, heterozygous mice may be bred together or with wildtype mice from the colony. The donating investigator reports breeding homozygous mice together with no fertility or viability problems.
- Additional Breeding and Husbandry Support
Mating System
- Homozygote x Homozygote

Animal Health Reports

Facility Barrier Level Descriptions

AX10 (Standard)

Pricing & Availability

Repository Live

Domestic
International

Live Mouse

Age

Genotype

Price

weeks

Cryorecovery - Pricing

Service	Genotype	Price
	Please inquire

We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.

Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.

Related Products and Services

Frozen Mouse Embryo

$2,595.00 per straw or vial

Payment Terms and Conditions

Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.

The Jackson Laboratory's Genotype Promise

The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project.

Terms Of Use

Terms of Use

General Terms and Conditions

Questions about Terms of Use

Additional Use Restrictions Apply

Use of MICE by companies or for-profit entities requires a license prior to shipping.

Licensing Information

Phone: 207-288-6470

Email: TechTran@jax.org

JAX® Mice, Products & Services Conditions of Use

"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.

No Warranty

MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.

Credit for PRODUCTS or SERVICES

In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.

Animal Care and Use for SERVICES

Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.

No Liability

In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.

MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.

The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.

Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.

Also Known As: R26R-Brainbow2.1, R26R-Confetti

Donating Investigator

Genetic overview

Research Applications

Base Price

Detailed Description

Development

Expression Data

Control Suggestions

Approximate Controls

Additional Information

Selected References

Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle

Allele Symbol: Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: GFP related

Genotype: YFP related

Mammalian Phenotype Terms by Genotype

Genotype: Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle/Gt(ROSA)26Sor+involves: 129P2/OlaHsd

no phenotypic analysis

References

Additional - Gt(ROSA)26Sortm1(CAG-Brainbow2.1)Cle

Genotyping Protocols

Dietary Information

Breeding Considerations

Mating System

Animal Health Reports

Live Mouse

Cryorecovery - Pricing

Related Products and Services

Payment Terms and Conditions

The Jackson Laboratory's Genotype Promise

Terms of Use

Additional Use Restrictions Apply

Licensing Information

JAX® Mice, Products & Services Conditions of Use

No Warranty

Credit for PRODUCTS or SERVICES

Animal Care and Use for SERVICES

No Liability

Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}

Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}

Genotype: Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}/Gt(ROSA)26Sor⁺
involves: 129P2/OlaHsd

Additional - Gt(ROSA)26Sor^{tm1(CAG-Brainbow2.1)Cle}