This Chromosome 4 congenic stock contains the C57BL/10SnJ derived Idd9.2 region introgressed into the NOD/MrkTac background and is partially protected from diabetes. This strain may be useful for positional mapping and studying candidate genes within the Idd9.2 region.
Linda Wicker, University of Cambridge, UK
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
QTL | Idd9.2 | insulin dependent diabetes susceptibility 9.2 |
This NOD/MrkTac congenic stock, commonly referred to as NOD.B10-Idd9.2 line 1566, carries C57BL/10SnJ (Stock No. 000666) derived genome on chromosome 4 containing the Idd9.2 region.
This strain is partially protected from diabetes. It has been reported that the Idd9.2 region contains a mechanism that strongly modulates CD8+tolerance.
This strain may be useful for positional mapping of the Idd9.2 loci and studying candidate genes within the Idd9.2 region.
This NOD congenic stock contains a genomic segment derived from C57BL/10SnJ (Stock No. 000666) introgressed into the Idd9.2 region of Chromosome 4. This strain was produced by mating mice from NOD/MrkTac to C57BL/10SnJ followed by 13 additional crosses (N14) to NOD/MrkTac with selection for Idd9.2 markers. Siblings carrying the 4Mb C57BL/10SnJ derived chromosomal segment denoted by markers AL606963(TA) (144Mb) through Clstn1-RE (148Mb) were intercrossed to make homozygous. 5kSNP Chip Data identifies no C57BL/10SnJ genetic contamination outside of the Chromosome 4 congenic interval. In 2010, the Type 1 Diabetes Resource received this strain at generation N14F20.
Allele Name | C57BL/10SnJ |
---|---|
Allele Type | QTL |
Allele Synonym(s) | |
Gene Symbol and Name | Idd9.2, insulin dependent diabetes susceptibility 9.2 |
Gene Synonym(s) | |
Strain of Origin | C57BL/10SnJ |
Chromosome | 4 |
Molecular Note | This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac. |
While maintaining a live colony, these mice are mated homozygous (for the congenic interval) female to homozygous males.
When using the NOD.B10-Idd9.2 line 1566 mouse strain in a publication, please cite the originating article(s) and include JAX stock #013253 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous |
Frozen Mouse Embryo | NOD.B10Sn-Idd9.2<C57BL/10SnJ>/1566MrkTacJ | $2595.00 |
Frozen Mouse Embryo | NOD.B10Sn-Idd9.2<C57BL/10SnJ>/1566MrkTacJ | $2595.00 |
Frozen Mouse Embryo | NOD.B10Sn-Idd9.2<C57BL/10SnJ>/1566MrkTacJ | $3373.50 |
Frozen Mouse Embryo | NOD.B10Sn-Idd9.2<C57BL/10SnJ>/1566MrkTacJ | $3373.50 |
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