NOD.B10Sn-Idd9.2^C57BL/10SnJ/1566MrkTacJ

Stock number: 013253
Product name: NOD.B10-Idd9.2 line 1566
Research areas: Diabetes and Obesity Research, Immunology, Inflammation and Autoimmunity Research

Description

This Chromosome 4 congenic stock contains the C57BL/10SnJ derived Idd9.2 region introgressed into the NOD/MrkTac background and is partially protected from diabetes. This strain may be useful for positional mapping and studying candidate genes within the Idd9.2 region.

Detailed description

This NOD/MrkTac congenic stock, commonly referred to as NOD.B10-Idd9.2 line 1566, carries C57BL/10SnJ (Stock No. 000666) derived genome on chromosome 4 containing the Idd9.2 region.
This strain is partially protected from diabetes. It has been reported that the Idd9.2 region contains a mechanism that strongly modulates CD8⁺tolerance.

This strain may be useful for positional mapping of the Idd9.2 loci and studying candidate genes within the Idd9.2 region.

Development

This NOD congenic stock contains a genomic segment derived from C57BL/10SnJ (Stock No. 000666) introgressed into the Idd9.2 region of Chromosome 4. This strain was produced by mating mice from NOD/MrkTac to C57BL/10SnJ followed by 13 additional crosses (N14) to NOD/MrkTac with selection for Idd9.2 markers. Siblings carrying the 4Mb C57BL/10SnJ derived chromosomal segment denoted by markers AL606963(TA) (144Mb) through Clstn1-RE (148Mb) were intercrossed to make homozygous. 5kSNP Chip Data identifies no C57BL/10SnJ genetic contamination outside of the Chromosome 4 congenic interval. In 2010, the Type 1 Diabetes Resource received this strain at generation N14F20.

Allele

Symbol: Idd9.2^C57BL/10SnJ
Name: C57BL/10SnJ
MGI accession ID: MGI:3036807
Generation method: QTL
Marker symbol: Idd9.2
Marker name: insulin dependent diabetes susceptibility 9.2
Chromosome: 4
Strain of origin: C57BL/10SnJ
Molecular note: This allele confers resistance to insulin dependent diabetes compared to NOD/MrkTac.