Homozygotes: Mice that are homozygous for the mutation are viable and fertile. Mice exhibit multiple limb patterning defects, but not the germ cell depletion phenotype observed in other Zbtb16 alleles. Hindlimb polydactyly exists in 100% of mice however, other skeletal deformities exhibit varying degrees of penetrance including hindpaw webbing (20%), metatarsal fusions (13%), failure of the tibia and fibia to fuse (47%), thickened fibulae (40%), absence of the fibula (33%), elongated 8th and 9th ribs (73%) and malformed xiphoid processes (40%). The donating investigator indicates that homozygous mice weigh approximately 17% less than controls. This mutant mouse strain may be useful in studies of skeletal development and germ cell lineage.


Heterozygote: Less than 3% of heterozygotes exhibit the hindlimb polydactyly phenotype.

These ENU-induced 7 toe (7t) mutants exhibit multiple limb patterning defects, including hindlimb polydactyly, hindpaw webbing, metatarsal fusions, failure of the tibia and fibia to fuse, and elongated 8th and 9th ribs. This mutant mouse strain may be useful in studies of skeletal development and germ cell lineage.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.