Homozygotes: Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Expression of the microtubule-associated protein tau/Green Fluorescent Protein fusion gene, "tauGFP" is controlled by Itpr3 regulatory elements. GPF expression is directed to microvillous cells in the olfactory epithelium. This mutant mouse strain may be useful in studies of taste transduction.

Heterozygote: Heterozygote phenotype is expected to be similar to homozygote phenotype.

In this knockin strain tauGFP replaces exon 1; expression of tauGFP is controlled by Itpr3 regulatory elements and is directed to microvillous cells in the olfactory epithelium. This mutant mouse strain may be useful in studies of taste transduction.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.