These mice possess loxP sites on either side of an exon encoding portions of both the PDZ1 and PDZ2 domains of the Dlg1 (discs, large homolog 1 (Drosophila); SAP97) gene. Mice that are homozygous for this floxed allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene.
Widespread deletion of expression leads to neonatal lethality due to failure of maxillar bone fusion. If deletion is specific to motor neurons (Stock No. 006600), neurite extension is suppressed. This strain may be useful for further characterizaton of the targeted gene's synaptic function.
When bred to mice carrying Tg(Cd4-cre)1Cwi (Stock No. 017336), Cre recombinase expression in the CD4-expressing T cells results un decreased Th1-associated cytokine production and increased Th2-associated cytokine production following anti-CD3 stimulation.
When bred to mice carrying Tg(Mpz-cre)26Mes (Stock No. 017927), Cre recombinase expression in Schwann cells results hypermyelination.
