Mice heterozygous for the dominant tail short mutation have kinked, shortened tails that range from one quarter to three quarters the length of a normal tail. The number of kinks varies and the average is slightly over 3. This mutant is also prone to hydrocephalus and aberrant cells have been found in the testis. No homozygotes have been identified to date, although predicted Mendelian segregation and complete penetrance is found in heterozygotes.
The dominant tail short mutation arose spontaneously on the CBA/J inbred background at The Jackson Laboratory in the year 2000 and has been maintained on this inbred background by sibling inbreeding ever since.
|Allele Name||dominant tail short|
|Gene Symbol and Name||Rpl31, ribosomal protein L31|
|Strain of Origin||CBA/J|
|Molecular Note||This is a spontaneous deletion of AATAAAGTTGCAG / ATAAAGTTGCAGA / TAAAGTTGCAGAA from the AATAAAGTTGCAGAA sequence at position 39,371,347-361 (GRCm38) in the 3' UTR.|