STOCK Map3k11^m1J/GrsrJ

Stock number: 012874
Product name: bloodline
Research areas: Cell Biology Research, Dermatology Research, Developmental Biology Research, Internal/Organ Research

Description

Homozygoue mutants show dorsal lines of dark red skin and necrotic dental pulp during early post-natal development.

Detailed description

Mice homozygous for the Map3k11^m1J mutation can be identified easily as early as 3 to 4 days of age by the dorsal lines of dark red skin that run from head to tail along the spine and from left to right across the crown of the head, base of the neck in front of the shoulders, and between the base of the ribs and the pelvis. These lines fade away and by 3 weeks of age are no longer evident even when the homozygote is shaved to expose the skin. Homozygotes have necrotic dental pulp, which also improves with age.

Development

The Map3k11^m1J mutation arose spontaneously in the STOCK Bdnf^tm3Jae/J strain at The Jackson Laboratory in 2004. This mutant subline was maintained by sibling inbreeding for many generations before being outcrossed for two consecutive generations to BALB/cByJ and then maintained by intercross selecting out the Bdnf^tm3Jae mutation. This mutant subline reached generation N2F2 in 2011.

Allele

Symbol: Map3k11^m1J
Name: mutation 1 Jackson
MGI accession ID: MGI:4999723
Generation method: Spontaneous
Synonyms: bloodline
Marker symbol: Map3k11
Marker name: mitogen-activated protein kinase kinase kinase 11
Marker synonyms: 2610017K16Rik; MEKK11; MLK3; MLK-3; PTK1; RHOE; SPRK
Chromosome: 19
Strain of origin: STOCK Bdnf^tm3Jae/J
Molecular note: A spontaneous G-to-A mutation at position 5,695,295 (GRCm38) changes amino acid 293 from glutamate to lysine (p.E293K).