Homozygoue mutants show dorsal lines of dark red skin and necrotic dental pulp during early post-natal development.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Map3k11 | mitogen-activated protein kinase kinase kinase 11 |
Mice homozygous for the Map3k11m1J mutation can be identified easily as early as 3 to 4 days of age by the dorsal lines of dark red skin that run from head to tail along the spine and from left to right across the crown of the head, base of the neck in front of the shoulders, and between the base of the ribs and the pelvis. These lines fade away and by 3 weeks of age are no longer evident even when the homozygote is shaved to expose the skin. Homozygotes have necrotic dental pulp, which also improves with age.
The Map3k11m1J mutation arose spontaneously in the STOCK Bdnftm3Jae/J strain at The Jackson Laboratory in 2004. This mutant subline was maintained by sibling inbreeding for many generations before being outcrossed for two consecutive generations to BALB/cByJ and then maintained by intercross selecting out the Bdnftm3Jae mutation. This mutant subline reached generation N2F2 in 2011.
Allele Name | mutation 1 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | bloodline |
Gene Symbol and Name | Map3k11, mitogen-activated protein kinase kinase kinase 11 |
Gene Synonym(s) | |
Strain of Origin | STOCK Bdnftm3Jae/J |
Chromosome | 19 |
Molecular Note | A spontaneous G-to-A mutation at position 5,695,295 (GRCm38) changes amino acid 293 from glutamate to lysine (p.E293K). |
When using the bloodline mouse strain in a publication, please cite the originating article(s) and include JAX stock #012874 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous for Map3k11<m1J> |
Frozen Mouse Embryo | STOCK Map3k11<m1J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | STOCK Map3k11<m1J>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | STOCK Map3k11<m1J>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | STOCK Map3k11<m1J>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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