C3.Cg-H2^p hael/GrsrJ

Stock number: 012855
Product name: hyperactive early lethal
Research areas: Developmental Biology Research, Neurobiology Research

Description

Mice homozygous for the spontaneous hael mutation appear normal at two weeks of age, but are either found dead or die following a hyperactive spurt then tonic seizure at around 20-21 days of age.

Detailed description

Mice homozygous for the spontaneous hael mutation appear normal at two weeks of age, but are either found dead or die following a hyperactive spurt then tonic seizure at around 20-21 days of age. One homozygote and one heterozygote died after treatment with atropine, but it is not known if this was an anomaly or attributable to the hael mutation. Because of the phenotype this mutation must be maintained by sibling intercrossing progeny tested heterozygotes.

Development

This mutation arose spontaneously on the histocompatibility congenic strain C3.NB-H2^p/SnJ (Stock No. 000439) and has been maintained by sibling breeding ever since.

Allele

Symbol: H2^p
Name: p variant
MGI accession ID: MGI:5751521
Generation method: Not Applicable
Marker symbol: H2
Marker name: histocompatibility-2, MHC
Marker synonyms: H-2; MHC-II
Chromosome: 17
Strain of origin: various
Molecular note: The p haplotype of the H2 complex is known to be present in the inbred strains F/St, NB, and P/J.

Allele

Symbol: hael
Name: hyperactive early lethal
MGI accession ID: MGI:5774454
Generation method: Spontaneous
Attributes: Not Applicable
Marker symbol: hael
Marker name: hyperactive early lethal
Chromosome: UN
Strain of origin: C3.NB-H2^p H2-T18^c?/SnJ
Molecular note: This heritable phenotype arose spontaneously at The Jackson Laboratory.