Mice homozygous for the spontaneous hael mutation appear normal at two weeks of age, but are either found dead or die following a hyperactive spurt then tonic seizure at around 20-21 days of age.
Read More +Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | H2 | histocompatibility-2, MHC |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Not Applicable) | hael | hyperactive early lethal |
Mice homozygous for the spontaneous hael mutation appear normal at two weeks of age, but are either found dead or die following a hyperactive spurt then tonic seizure at around 20-21 days of age. One homozygote and one heterozygote died after treatment with atropine, but it is not known if this was an anomaly or attributable to the hael mutation. Because of the phenotype this mutation must be maintained by sibling intercrossing progeny tested heterozygotes.
This mutation arose spontaneously on the histocompatibility congenic strain C3.NB-H2p/SnJ (Stock No. 000439) and has been maintained by sibling breeding ever since.
Allele Name | p variant |
---|---|
Allele Type | Not Applicable |
Allele Synonym(s) | |
Gene Symbol and Name | H2, histocompatibility-2, MHC |
Gene Synonym(s) | |
Strain of Origin | various |
Chromosome | 17 |
Molecular Note | The p haplotype of the H2 complex is known to be present in the inbred strains F/St, NB, and P/J. |
Allele Name | hyperactive early lethal |
---|---|
Allele Type | Spontaneous (Not Applicable) |
Allele Synonym(s) | |
Gene Symbol and Name | hael, hyperactive early lethal |
Gene Synonym(s) | |
Strain of Origin | C3.NB-H2p H2-T18c?/SnJ |
Chromosome | UN |
Molecular Note | This heritable phenotype arose spontaneously at The Jackson Laboratory. |
hael/GrsrJ
When using the hyperactive early lethal mouse strain in a publication, please cite the originating article(s) and include JAX stock #012855 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Progeny testing required but not provided. No genotyping assay is available for these recessive cryo-recovered animals of undefined genotype |
Frozen Mouse Embryo | C3.Cg-H2<p> hael/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C3.Cg-H2<p> hael/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C3.Cg-H2<p> hael/GrsrJ | $3373.50 |
Frozen Mouse Embryo | C3.Cg-H2<p> hael/GrsrJ | $3373.50 |
Terms are granted by individual review and stated on the customer invoice(s) and account statement. These transactions are payable in U.S. currency within the granted terms. Payment for services, products, shipping containers, and shipping costs that are rendered are expected within the payment terms indicated on the invoice or stated by contract. Invoices and account balances in arrears of stated terms may result in The Jackson Laboratory pursuing collection activities including but not limited to outside agencies and court filings.
The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
What information were you hoping to find through your search?
How easy was it to find what you were looking for?
We may wish to follow up with you. Enter your email if you are happy for us to connect and reachout to you with more questions.
Please Enter a Valid Email Address
Thank you for sharing your feedback! We are working on improving the JAX Mice search. Come back soon for exciting changes.