JAX Mouse Strain Datasheet - 012845

CByJ.129S7(B6)-Ldlr^tm1Her/J

Stock No:: 012845

Cryo Recovery

Overview

These BALB.LDLR knock-out mice may be useful for studying the effects of hyperlipidemia and hyperglycemia on diabetic nephrology and artherosclerosis.

Donating Investigator

Dr. Renee C LeBoeuf, Universtiy of Washington

Genetic overview

Genetic Background	Generation

Ldlr^tm1Her

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Ldlr	low density lipoprotein receptor

View Genetics

Research Applications

Cardiovascular Research
Diabetes and Obesity Research
Internal/Organ Research
Metabolism Research

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

In the BALB.LDLR^-/- strain, a neomycin (neo) selection cassette is inserted in exon 4 of the low density lipoprotein receptor (Ldlr) gene, abolishing endogenous gene function. Homozygous mice are viable, fertile, appear normal in size, and do not display any gross physical or behavioral abnormalities. On a 4% diet, BALB.LDLR^-/- mice have increased cholesterol (~200 mg/dl), increased triglycerides (~170mg/dl), and increased blood glucose (122 mg/dl) as compared with wildtype (WT). When moved onto a 21% fat diet these mice have cholesterol levels of 572 mg/dl, triglyceride levels of 180mg/dl, and blood glucose levels of 141 mg/dl. They exhibit renal injury, tubulointerstitial injury, and an increase in interstitial macrophages, and an increase in blood urea nitrogen when challenged with hyperlipidemia and hyperglycemia. When injected with Streptozotocin these mice also exhibit atherosclerotic lesions, aortic sinus lesions, and aortic fatty streak lesions caused by hyperlipidemia. These mice may be useful for studying the effects of hyperlipidemia and hyperglycemia on diabetic nephrology and artherosclerosis.

Development

A targeting vector was designed to insert neomycin (neo) selection cassette into exon 4 of the low density lipoprotein receptor (Ldlr) gene, abolishing gene function. This construct was electroporated into 129S7/SvEvBrd-Hprt1⁺-derived AB-1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts and chimeric males were bred with C57BL/6 females. The resulting offspring were backcrossed to C57BL/6 for at least 10 generations to establish a colony of Ldlr^-/- mice (Stock No. 002207). These mice were subsequently backcrossed to BALB/cByJ for at least 10 generations to establish a colony of BALB.LDLR^-/- mice. Upon arrival at The Jackson Laboratory, mice were bred with BALB/cByJ inbred mice (Stock No. 001026) for at least one generation to establish the colony.

Control Suggestions

Approximate Controls

001026 BALB/cByJ

Additional Information

Considerations for Choosing Controls

Selected References

Ishibashi S; Brown MS; Goldstein JL; Gerard RD; Hammer RE; Herz J. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments] J Clin Invest 92(2):883-93. PubMed: 8349823 MGI: J:37394

View All References

Genetics

Ldlr^tm1Her

Allele Symbol: Ldlr^tm1Her

Allele Name	targeted mutation 1, Joachim Herz
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	LDLR KO; LDLR-; LDLr-KO; LDLr0; LDLrKO; Ldlrtm1Her
Gene Symbol and Name	Ldlr, low density lipoprotein receptor
Gene Synonym(s)	FH; FHC; LDLCQ2; LDLRA
Site of Expression	Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals.
Strain of Origin	129S7/SvEvBrd-Hprt<+>
Chromosome	9
General Note	When used in bone marrow transplant into Ldlr^tm1Her homozygous mice, Abca1^tm1Jdm Abcg1^tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777) Phenotypic Similarity to Human Syndrome: Atherosclerosis, Susceptibility to J:29950, J:225091 in mice fed a high-cholesterol diet.
Molecular Note	Insertion of a neomycin resistance cassette into exon 4. The authors predict that the targeted allele would encode a truncated non-functional protein that will not bind LDL, and that lacks a membrane spanning segment. Immunoblot analysis of liver membranes detected a truncated protein in homozygous mutant animals.
Mutations Made By	Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Cardiovascular Research
- Hypercholesterolemia
Diabetes and Obesity Research
- Hyperglycemia
- Hyperinsulinemia
  - diet-induced
Internal/Organ Research
- Kidney Defects
  - Renal tubulointerstitial lesions
Metabolism Research
- Lipid Metabolism

Genotype: Ldlr^tm1Her related

Cardiovascular Research
- Atherosclerosis
- Hypercholesterolemia
Metabolism Research
- Lipid Metabolism

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Ldlr^tm1Her/Ldlr⁺
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

homeostasis/metabolism phenotype

hyperglycemia
- streptozotocin (STZ) treatment leads to 3-fold higher level of blood glucose in mice fed a high fat diet
- these high glucose levels persist for at least 12 weeks after STZ treatment

Genotype: Ldlr^tm1Her/Ldlr⁺
B6.129S7-Ldlr^tm1Her

homeostasis/metabolism phenotype

increased circulating cholesterol level
- seen at 3-4 months of age

increased circulating triglyceride level
- seen at 3-4 months of age

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA

homeostasis/metabolism phenotype

abnormal cholesterol homeostasis
- increase in the APOB lipoprotein cholesterol level compared to wild-type controls
- plasma cholesterol is nearly equal distribution between the HDL and LDL fractions
- the ratio of saturated + monounsaturated/polyunsaturated cholesterol ester fatty acid species in the LDL fraction is significantly decreased compared to Apoe^tm1Unc single mutantsts
- there is a 2.3 fold decrease in the ratio of saturated + monounsaturated/polyunsaturated cholesterol ester fatty acid species compared to Apoe^tm1Unc single mutants

abnormal circulating protein level
- increase in APOB-100

abnormal lipid homeostasis
- the HDL phospholipid fraction contains less 16:0 and 18:0 species and is enriched for 20:4 and 22:6 species compared to Apoe^tm1Unc single mutants

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S7/SvEvBrd

homeostasis/metabolism phenotype

abnormal circulating LDL cholesterol level
- LDL clearance is slowed

abnormal circulating cholesterol level
- circulating VLDL/LDL cholesterol levels are increased compared to in Apobec1^tm1Chan homozygotes and wild-type mice

increased circulating LDL cholesterol level
- in wild-type mice parabiosed with Ldlr-null mice (resulting in shared circulation), plasma total cholesterol levels did not increase significantly over pre-surgery levels
- male mice have a marked increase in plasma LDL cholesterol compared to wild-type
- on a chow diet, plasma LDL levels were higher than both those of wild-type mice and Ldlrap1^tm1Her homozygous mutant mice
- plasma LDL levels become further elevated on high cholesterol diets
- plasma levels are increased 2.5 fold relative to controls

increased circulating cholesterol level
- increased plasma cholesterol levels after 20 weeks on Western diet
- levels are higher than those exhibited by in transgenic Tg(Alb-MYLIP*)1Pton mice after 30 weeks on Western diet
- plasma cholesterol level is 196mg/dl on a normal diet
- when fed a chow diet or Western-type diet for 2 and 4 weeks, mice exhibit increased serum cholesterol levels compared to in Apobec1^tm1Chan homozygotes and wild-type mice

increased circulating triglyceride level
- when fed a chow diet or a Western-type diet for 2 and 4 weeks, mice exhibit increased serum triglyceride levels compared to in Apobec1^tm1Chan homozygotes and wild-type mice

cardiovascular system phenotype

atherosclerotic lesions
- mice develop atherosclerotic lesions after 20 weeks on Western diet
- total lesion area is larger when compared to lesion area in transgenic Tg(Alb-MYLIP*)1Pton mice after 30 weeks on Western diet

increased susceptibility to atherosclerosis

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
B6.129S7-Ldlr^tm1Her

homeostasis/metabolism phenotype

abnormal circulating cholesterol level
- streptozotocin (STZ) induced diabetes leads to blood cholesterol levels that are twice those of non-diabetic mice 6 weeks post-induction and three times greater 8 weeks post- induction
- when fed a western style diet for 12 weeks, male mice exhibit a higher circulating cholesterol level than in Ldlr^tm1Her Scd1^ab-2J homozygotes

abnormal triglyceride level

amyloid beta deposits
- increased amyloid beta 40 but not amyloid beta 42 on a high fat diet

decreased circulating HDL cholesterol level
- when fed a high-cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for HDL of 0.77 compared to 0.83 in wild-type mice

decreased circulating interleukin-10 level

hyperglycemia
- streptozotocin (STZ) treatment leads to 3-fold higher level of blood glucose in mice fed a high fat diet
- these high glucose levels persist for at least 12 weeks after STZ treatment
- when fed a western style diet for 12 weeks

impaired glucose tolerance
- when fed a western style diet for 12 weeks

increased circulating HDL cholesterol level
- slightly elevated at 3 and 8 months of age

increased circulating LDL cholesterol level
- when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for LDL of 0.88 compared to 0.84 in wild-type mice

increased circulating VLDL cholesterol level
- compared to in Ldlr^tm1Her Scd1^ab-2J homozygotes when fed a western style diet for 12 weeks
- when fed a high cholesterol diet, NMR proton spectra of lipids indicates a level of photon intensity for VLDL of 0.92 compared to 0.88 in wild-type mice

increased circulating VLDL triglyceride level
- compared to in Ldlr^tm1Her Scd1^ab-2J homozygotes when fed a western style diet for 12 weeks

increased circulating cholesterol level
- 10 fold increase in total cholesterol on a high fat diet compared to a 150% increase for controls
- 3 fold cholesterol elevation on a normal diet relative to controls
- mice develop severe cholesterolemia when receiving a high fat diet from 6 to 30 weeks (elevated levels are detected at 6, 15, and 30 weeks)
- seen at 3-4 months of age

increased circulating insulin level
- when fed a western style diet for 12 weeks

increased circulating interleukin-1 beta level

increased circulating interleukin-6 level

increased circulating triglyceride level
- elevated on a high fat diet
- seen at 3-4 months of age
- when fed a western style diet for 12 weeks, female mice exhibit a higher circulating triglyceride level than in Ldlr^tm1Her Scd1^ab-2J homozygotes

increased circulating tumor necrosis factor level
- increased TNFalpha levels

increased liver cholesterol level
- livers exhibit slightly, but significantly, higher levels of cholesterol

increased liver triglyceride level
- when fed a western style diet for 12 weeks, mice exhibit a 5-fold higher hepatic triglyceride level than in Ldlr^tm1Her Scd1^ab-2J homozygotes

adipose tissue phenotype

abnormal fat pad morphology
- increased when fed a western style diet for 12 weeks

increased percent body fat/body weight
- when fed a western style diet for 12 weeks

growth/size/body region phenotype

decreased susceptibility to weight gain
- lower body weight on a low cholesterol diet than controls on any diet

increased susceptibility to weight gain
- when fed a western style diet for 12 weeks

cardiovascular system phenotype

atherosclerotic lesions

increased susceptibility to atherosclerosis
- 4 weeks on the Western diet mice have lesions of small fatty streaks on the aorta
- STZ-induced diabetes leads to an almost 3-fold greater size in total lesion area in the aorta compared to non-diabetic Ldlr^tm1Her homozyogotes
- after 12 weeks on a high cholesterol diet, mice exhibit endothelial disruption and an accumulation of macrophage and foam cells at the site of atherosclerotic plaques
- after 12 weeks on a high cholesterol diet, mice exhibit extensive intimal thickening and 60% to 80% of the aortic surface is sudanophilic unlike in wild-type mice
- high-fat diet leads to atherosclerosis

immune system phenotype

abnormal microglial cell morphology
- increased number of microglia in the hippocampus

decreased circulating interleukin-10 level

increased circulating interleukin-1 beta level

increased circulating interleukin-6 level

increased circulating tumor necrosis factor level
- increased TNFalpha levels

liver/biliary system phenotype

hepatic steatosis
- when fed a western style diet for 12 weeks

increased liver cholesterol level
- livers exhibit slightly, but significantly, higher levels of cholesterol

increased liver triglyceride level
- when fed a western style diet for 12 weeks, mice exhibit a 5-fold higher hepatic triglyceride level than in Ldlr^tm1Her Scd1^ab-2J homozygotes

behavior/neurological phenotype

abnormal spatial learning
- take longer to reach the target site in a Morris water maze when fed a high cholesterol diet

abnormal spatial working memory
- deficient performance in a water radial arm maze regardless of the diet

hyperactivity
- travel greater distances and spend more time in motion in an open field test

increased grip strength
- perform better than controls on a hanging bar test

nervous system phenotype

abnormal CNS glial cell morphology

abnormal astrocyte morphology
- further increase in reactive astrocytes on a high fat diet
- increased numbers of reactive astrocytes

abnormal microglial cell morphology
- increased number of microglia in the hippocampus

amyloid beta deposits
- increased amyloid beta 40 but not amyloid beta 42 on a high fat diet

hematopoietic system phenotype

abnormal microglial cell morphology
- increased number of microglia in the hippocampus

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

cardiovascular system phenotype

atherosclerotic lesions
- atherosclerosis in both aortic arch and descending aorta

homeostasis/metabolism phenotype

increased circulating cholesterol level
- hypercholesterolemic

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S7/SvEvBrd * C57BL/6J

cardiovascular system phenotype

atherosclerotic lesions
- males show more aortic atherosclerosis than females, both in the arch and in the thoracic and abdominal aorta, whereas the average plasma cholesterol levels are similar in males and females
- mice fed a cholate-free high-cholesterol diet (1%) for 6 months develop more extensive lesions throughout the aorta compared to controls which show smaller lesions that are almost exclusively in the aortic origin; the extent of atherosclerosis in the entire aorta correlates with the size of lesions in the aortic originre aorta correlates with the size of lesions in the aortic origin

increased susceptibility to atherosclerosis
- when fed a high-cholesterol diet, mice develop more extensive atherosclerotic lesions than similarly fed controls, with males more affected than females

homeostasis/metabolism phenotype

increased circulating cholesterol level
- mice fed a high-fat diet (1% cholesterol) exhibit increased average total plasma cholesterol levels

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
B6.129S7-Ldlr^tm1Her/J

homeostasis/metabolism phenotype

decreased circulating triglyceride level
- when fed regular chow or a high fat diet for 16 weeks, serum triglyceride levels are decreased compared to similarly treated Apoa1^tm1Unc Ldlr^tm1Her homozygotes

homeostasis/metabolism phenotype
- mice fed a Western diet exhibit normal HDL cholesterol

increased cholesterol level
- when fed a high fat diet, mice exhibit an increase in cholesterol content in the adrenal gland

increased circulating HDL cholesterol level
- when fed regular chow or a high fat diet for 16 weeks, serum HDL levels are increased compared to similarly treated Apoa1^tm1Unc Ldlr^tm1Her homozygotes

increased circulating LDL cholesterol level
- when fed a Western diet compared to Ldlr^tm1Her homozygotes fed regular chow
- when fed a high fat diet, mice exhibit a greater increase in VLDL and LDL (6-fold) compared to Ldlr^tm1Her homozygotes (3-fold)

increased circulating VLDL cholesterol level
- when fed a Western diet
- when fed a high fat diet, mice exhibit a greater increase in VLDL and LDL (6-fold) compared to Ldlr^tm1Her homozygotes (3-fold)

increased circulating cholesterol level
- 15 fold higher on a normal diet than controls
- 40 fold higher than controls on a high fat diet
- when fed a high fat diet, mice exhibit a greater increase in VLDL and LDL (6-fold) compared to Ldlr^tm1Her homozygotes (3-fold)
- whether are fed a high fat diet or regular chow, plasma cholesterol levels are increased relative to similarly treated Apoa1^tm1Unc Ldlr^tm1Her homozygotes

increased circulating triglyceride level
- when fed a Western diet

increased liver cholesterol level
- when fed a high fat diet, mice exhibit a greater increase in liver cholesterol content (11-fold) compared to in similarly treated Apoa1^tm1Unc Ldlr^tm1Her homozygotes (2.5-fold)

liver/biliary system phenotype

abnormal liver physiology
- LDL updake is decreased by about 2X

hepatic steatosis
- when fed a high fat diet, mice exhibit larger diameter and more frequent lipid droplets than in Apoa1^tm1Unc Ldlr^tm1Her homozygotes

increased liver cholesterol level
- when fed a high fat diet, mice exhibit a greater increase in liver cholesterol content (11-fold) compared to in similarly treated Apoa1^tm1Unc Ldlr^tm1Her homozygotes (2.5-fold)

endocrine/exocrine gland phenotype

abnormal adrenal gland morphology
- when fed a high fat diet, mice exhibit an increase in cholesterol content in the adrenal gland

cardiovascular system phenotype

atherosclerotic lesions
- after 8 or 20 weeks on a cholesterol diet aortic lesion size is increased compared to mice that are homozygous for both Ldlr^tm1Her and Ifng^tm1Ts

integument phenotype

alopecia
- when fed a high fat diet

scaly skin
- when fed a high fat diet

thick skin
- when fed a high fat diet

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S7/SvEvBrd * C57BL/6

growth/size/body region phenotype

decreased lean body mass

obese
- mice fed a diabetogenic high fat diet (35.5% carbohydrate and 36.6% fat) (DD diet) or a a diabetogenic high fat diet (35.5% carbohydrate and 36.6% fat) with 0.15% added cholesterol (DDC diet) exhibit weight gain leading to obesity; similar weight gain is seen regardless of dietseen regardless of diet

pigmentation phenotype

abnormal retinal pigment epithelium morphology
- basal membrane infoldings are less regular
- decreased and irregular height
- numerous vacuoles in cytoplasm

cellular phenotype

increased hepatocyte apoptosis
- DD diet fed mice show some apoptotic cells in the liver while those on the DDC diet have a larger increase

maternal effect
- also reduced birth weight persisting to at least 90 days of age
- intrauterine growth restriction of pups from mothers on a high fat diet
- offspring with larger atherosclerotic lesions
- offspring with lower gonadal fat pad to body weight ratio
- poor survival of pups from mothers on a high fat diet

oxidative stress
- mice on the DDC diet exhibit an increase in hepatic oxidative stress

liver/biliary system phenotype

hepatic steatosis
- mice fed the DD diet exhibit diffuse macrovesicular steatosis with limited inflammation and fibrosis in the liver
- mice fed the DDC diet exhibit both macrovesicular and microvesicular steatosis in the liver

increased hepatocyte apoptosis
- DD diet fed mice show some apoptotic cells in the liver while those on the DDC diet have a larger increase

increased liver cholesterol level
- hepatic cholesterol levels are increased only in the mice fed the DDC diet

increased liver triglyceride level
- hepatic triglyceride levels are increased in mice fed the DD or the DDC diet, but higher in those on the DDC diet

increased liver weight
- mice on the DD diet and on the DDC diet exhibit higher liver weights than regular chow-fed mice

liver fibrosis
- intrasinusoidal and pericellular fibrosis is seen to a greater extend in the livers of mice fed the DDC diet than the DD diet

liver inflammation
- inflammatory cell foci is seen to a greater extend in the livers of mice fed the DDC diet than the DD diet

homeostasis/metabolism phenotype

abnormal circulating amino acid level
- levels of other amino acids are normal
- mothers on a high fat diet have reduced plasma concentrations of phenylalanine, lysine, valine, isoleucine, and leucine

abnormal glucose homeostasis

decreased circulating corticosterone level
- levels in response to ACTH are significantly reduced

impaired glucose tolerance
- 30 minute insulin levels elevated
- glucose levels increase during a glucose tolerance test

increased circulating LDL cholesterol level
- clearance of ¹²⁵I-LDL from circulation is retarded, uptake of DiI-LDL by hepatocytes is decreased, and uptake of ³H-CE-LDL by the liver is lower compared to wild-type

increased circulating alanine transaminase level
- ALT levels are increased in mice fed the DD diet and even more so in those fed the DDC diet

increased circulating cholesterol level
- similar levels of hypercholesterolemia are seen in mice fed the DD diet and those fed the DDC diet

increased circulating free fatty acid level
- circulating fatty free acids are increased in mice fed the DD or the DDC diet, however levels are higher in the mice on the DDC diet

increased circulating glucose level
- increased fasting glucose levels after dexamethasone treatment

increased circulating insulin level
- after dexamethasone treatment

increased circulating triglyceride level
- similar levels of hypertriglyceridemia are seen in mice fed the DD diet and those fed the DDC diet

increased liver cholesterol level
- hepatic cholesterol levels are increased only in the mice fed the DDC diet

increased liver triglyceride level
- hepatic triglyceride levels are increased in mice fed the DD or the DDC diet, but higher in those on the DDC diet

insulin resistance
- less likely to become hypoglycemic during an insulin tolerance test

nervous system phenotype

abnormal hippocampus morphology
- reduced cell proliferation in the hippocampus

abnormal microglial cell morphology
- 2X as many arterioles have microglia
- on a Western diet, even small arterioles have associated microglia, sometimes within the basal lamina

abnormal synapse morphology
- 32% of the cholesterol in the synaptic plasma membrane is in the exofacial leaflet as compared to 15% for controls
- cholesterol levels in the cytofacial leaflet are reduced
- cholesterol/phospholipid ratio in the synaptic plasma membrane is elevated
- fluidity of both the exofacial leaflet and the cytofacial leaflet of the synaptic plasma membrane are increased relative to controls

abnormal synaptic bouton morphology
- normal density of synaptophysin-immunoreactive presynaptic boutons in the dentate gyrus
- reduced density of synaptophysin-immunoreactive presynaptic boutons in the CA1 of the hippocampus

photoreceptor outer segment degeneration
- mild degeneration

cardiovascular system phenotype

abnormal arteriole morphology
- wall thickness increases on a Western diet
- wall thickness is directly related to the number of associated microglia
- wall thickness of brain arterioles having a lumen diameter of 15-40 um is greater than controls

abnormal choriocapillaris morphology
- narrowing of lumina
- reduced number of fenestrations
- thickened endothelial basal lamina

behavior/neurological phenotype

abnormal short term spatial reference memory
- mice fed a Western diet and tested in a T-maze demonstrate reduced alternation returning more frequently to the blind arm of the maze

abnormal spatial learning
- less time spent in the target quadrant during a probe test
- mice on a Western diet fail to show improved performance over time in a Morris water maze test
- somewhat slower swimming speed in the acquisition phase of a Morris water maze test

vision/eye phenotype

abnormal Bruch membrane morphology
- enhanced condensation of collagenous and elastic fibers
- laminations disrupted and large vacuoles become diffusely distributed
- thickened (up to 0.8um on a high fat diet)

abnormal choriocapillaris morphology
- narrowing of lumina
- reduced number of fenestrations
- thickened endothelial basal lamina

abnormal retinal pigment epithelium morphology
- basal membrane infoldings are less regular
- decreased and irregular height
- numerous vacuoles in cytoplasm

photoreceptor outer segment degeneration
- mild degeneration

hematopoietic system phenotype

abnormal microglial cell morphology
- 2X as many arterioles have microglia
- on a Western diet, even small arterioles have associated microglia, sometimes within the basal lamina

immune system phenotype

abnormal microglial cell morphology
- 2X as many arterioles have microglia
- on a Western diet, even small arterioles have associated microglia, sometimes within the basal lamina

liver inflammation
- inflammatory cell foci is seen to a greater extend in the livers of mice fed the DDC diet than the DD diet

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S7/SvEvBrd * C57BL/6 * SJL

homeostasis/metabolism phenotype

increased circulating LDL cholesterol level
- greatly elevated

increased circulating cholesterol level
- total cholesterol greatly elevated

References

Ishibashi S; Brown MS; Goldstein JL; Gerard RD; Hammer RE; Herz J. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments] J Clin Invest 92(2):883-93. PubMed: 8349823 MGI: J:37394

Additional - Ldlr^tm1Her related

Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. PubMed: 10727439 MGI: J:61147
Adachi H; Kondo T; Koh GY; Nagy A; Oike Y; Araki E. 2011. Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice. Biochem Biophys Res Commun 409(2):177-80. PubMed: 21549101 MGI: J:172599
Afek A; Keren G; Harats D; George J. 2001. Whole body hyperthermia accelerates atherogenesis in low-density lipoprotein receptor deficient mice. Exp Mol Pathol 71(1):63-72. PubMed: 11502098 MGI: J:106255
Ahmad PJ; Trcka D; Xue S; Franco C; Speer MY; Giachelli CM; Bendeck MP. 2009. Discoidin domain receptor-1 deficiency attenuates atherosclerotic calcification and smooth muscle cell-mediated mineralization. Am J Pathol 175(6):2686-96. PubMed: 19893047 MGI: J:155320
Ait-Oufella H; Herbin O; Lahoute C; Coatrieux C; Loyer X; Joffre J; Laurans L; Ramkhelawon B; Blanc-Brude O; Karabina S; Girard CA; Payre C; Yamamoto K; Binder CJ; Murakami M; Tedgui A; Lambeau G; Mallat Z. 2013. Group X secreted phospholipase A2 limits the development of atherosclerosis in LDL receptor-null mice. Arterioscler Thromb Vasc Biol 33(3):466-73. PubMed: 23349189 MGI: J:216884
Ait-Oufella H; Kinugawa K; Zoll J; Simon T; Boddaert J; Heeneman S; Blanc-Brude O; Barateau V; Potteaux S; Merval R; Esposito B; Teissier E; Daemen MJ; Leseche G; Boulanger C; Tedgui A; Mallat Z. 2007. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation 115(16):2168-77. PubMed: 17420351 MGI: J:135906
Ait-Oufella H; Pouresmail V; Simon T; Blanc-Brude O; Kinugawa K; Merval R; Offenstadt G; Leseche G; Cohen PL; Tedgui A; Mallat Z. 2008. Defective mer receptor tyrosine kinase signaling in bone marrow cells promotes apoptotic cell accumulation and accelerates atherosclerosis. Arterioscler Thromb Vasc Biol 28(8):1429-31. PubMed: 18467644 MGI: J:159811
Ait-Oufella H; Salomon BL; Potteaux S; Robertson AK; Gourdy P; Zoll J; Merval R; Esposito B; Cohen JL; Fisson S; Flavell RA; Hansson GK; Klatzmann D; Tedgui A; Mallat Z. 2006. Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med 12(2):178-80. PubMed: 16462800 MGI: J:105800
Albrecht C; Preusch MR; Hofmann G; Morris-Rosenfeld S; Blessing E; Rosenfeld ME; Katus HA; Bea F. 2010. Egr-1 deficiency in bone marrow-derived cells reduces atherosclerotic lesion formation in a hyperlipidaemic mouse model. Cardiovasc Res 86(2):321-9. PubMed: 20110335 MGI: J:175882
Alger HM; Brown JM; Sawyer JK; Kelley KL; Shah R; Wilson MD; Willingham MC; Rudel LL. 2010. Inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) prevents dietary cholesterol-associated steatosis by enhancing hepatic triglyceride mobilization. J Biol Chem 285(19):14267-74. PubMed: 20231283 MGI: J:162960
Allred KF; Smart EJ; Wilson ME. 2006. Estrogen receptor-alpha mediates gender differences in atherosclerosis induced by HIV protease inhibitors. J Biol Chem 281(3):1419-25. PubMed: 16299001 MGI: J:107322
Altenburg M; Arbones-Mainar J; Johnson L; Wilder J; Maeda N. 2008. Human LDL receptor enhances sequestration of ApoE4 and VLDL remnants on the surface of hepatocytes but not their internalization in mice. Arterioscler Thromb Vasc Biol 28(6):1104-10. PubMed: 18369154 MGI: J:149026
Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. PubMed: 15485633 MGI: J:93917
Anggraeni VY; Emoto N; Yagi K; Mayasari DS; Nakayama K; Izumikawa T; Kitagawa H; Hirata K. 2011. Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis. Biochem Biophys Res Commun 406(1):36-41. PubMed: 21284936 MGI: J:170936
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Yan D; Jauhiainen M; Hildebrand RB; Willems van Dijk K; Van Berkel TJ; Ehnholm C; Van Eck M; Olkkonen VM. 2007. Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol 27(7):1618-24. PubMed: 17478758 MGI: J:134908
Yan D; Navab M; Bruce C; Fogelman AM; Jiang XC. 2004. PLTP deficiency improves the anti-inflammatory properties of HDL and reduces the ability of LDL to induce monocyte chemotactic activity. J Lipid Res 45(10):1852-8. PubMed: 15258196 MGI: J:93620
Yancey PG; Ding Y; Fan D; Blakemore JL; Zhang Y; Ding L; Zhang J; Linton MF; Fazio S. 2011. Low-density lipoprotein receptor-related protein 1 prevents early atherosclerosis by limiting lesional apoptosis and inflammatory Ly-6Chigh monocytosis: evidence that the effects are not apolipoprotein E dependent. Circulation 124(4):454-64. PubMed: 21730304 MGI: J:186294
Yang X; Peterson L; Thieringer R; Deignan JL; Wang X; Zhu J; Wang S; Zhong H; Stepaniants S; Beaulaurier J; Wang IM; Rosa R; Cumiskey AM; Luo JM; Luo Q; Shah K; Xiao J; Nickle D; Plump A; Schadt EE; Lusis AJ; Lum PY. 2010. Identification and validation of genes affecting aortic lesions in mice. J Clin Invest 120(7):2414-22. PubMed: 20577049 MGI: J:163781
Ye D; Meurs I; Ohigashi M; Calpe-Berdiel L; Habets KL; Zhao Y; Kubo Y; Yamaguchi A; Van Berkel TJ; Nishi T; Van Eck M. 2010. Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem Biophys Res Commun 395(3):387-94. PubMed: 20382126 MGI: J:160341
Ye D; Zhao Y; Hildebrand RB; Singaraja RR; Hayden MR; Van Berkel TJ; Van Eck M. 2011. The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice. Am J Pathol 178(1):413-22. PubMed: 21224078 MGI: J:168077
Yen FT; Roitel O; Bonnard L; Notet V; Pratte D; Stenger C; Magueur E; Bihain BE. 2008. Lipolysis stimulated lipoprotein receptor: a novel molecular link between hyperlipidemia, weight gain, and atherosclerosis in mice. J Biol Chem 283(37):25650-9. PubMed: 18644789 MGI: J:142162
Yokoyama M; Seo T; Park T; Yagyu H; Hu Y; Son NH; Augustus AS; Vikramadithyan RK; Ramakrishnan R; Pulawa LK; Eckel RH; Goldberg IJ. 2007. Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscle. J Lipid Res 48(3):646-55. PubMed: 17189607 MGI: J:120271
Yoon J; Subramanian S; Ding Y; Wang S; Goodspeed L; Sullivan B; Kim J; O'Brien KD; Chait A. 2011. Chronic insulin therapy reduces adipose tissue macrophage content in LDL-receptor-deficient mice. Diabetologia :. PubMed: 21327868 MGI: J:169596
Yoshimatsu M; Terasaki Y; Sakashita N; Kiyota E; Sato H; van der Laan LJ; Takeya M. 2004. Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process. Int J Exp Pathol 85(6):335-43. PubMed: 15566430 MGI: J:104609
Yu F; Du F; Wang Y; Huang S; Miao R; Major AS; Murphy EA; Fu M; Fan D. 2013. Bone marrow deficiency of MCPIP1 results in severe multi-organ inflammation but diminishes atherogenesis in hyperlipidemic mice. PLoS One 8(11):e80089. PubMed: 24223214 MGI: J:209217
Yu KC; Chen W; Cooper AD. 2001. LDL receptor-related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice. J Clin Invest 107(11):1387-94. PubMed: 11390420 MGI: J:69912
Yu KC; Jiang Y; Chen W; Cooper AD. 2000. Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E J Lipid Res 41(11):1715-27. PubMed: 11060341 MGI: J:65695
Yu Y; Lucitt MB; Stubbe J; Cheng Y; Friis UG; Hansen PB; Jensen BL; Smyth EM; FitzGerald GA. 2009. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proc Natl Acad Sci U S A 106(19):7985-90. PubMed: 19416858 MGI: J:148401
Yun TJ; Lee JS; Machmach K; Shim D; Choi J; Wi YJ; Jang HS; Jung IH; Kim K; Yoon WK; Miah MA; Li B; Chang J; Bego MG; Pham TN; Loschko J; Fritz JH; Krug AB; Lee SP; Keler T; Guimond JV; Haddad E; Cohen EA; Sirois MG; El-Hamamsy I; Colonna M; Oh GT; Choi JH; Cheong C. 2016. Indoleamine 2,3-Dioxygenase-Expressing Aortic Plasmacytoid Dendritic Cells Protect against Atherosclerosis by Induction of Regulatory T Cells. Cell Metab 23(5):852-66. PubMed: 27166946 MGI: J:235369
Yvan-Charvet L; Pagler T; Gautier EL; Avagyan S; Siry RL; Han S; Welch CL; Wang N; Randolph GJ; Snoeck HW; Tall AR. 2010. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science 328(5986):1689-93. PubMed: 20488992 MGI: J:161310
Yvan-Charvet L; Ranalletta M; Wang N; Han S; Terasaka N; Li R; Welch C; Tall AR. 2007. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest 117(12):3900-8. PubMed: 17992262 MGI: J:130777
Zabalawi M; Bharadwaj M; Horton H; Cline M; Willingham M; Thomas MJ; Sorci-Thomas MG. 2007. Inflammation and skin cholesterol in LDLr-/-, apoA-I-/- mice: link between cholesterol homeostasis and self-tolerance? J Lipid Res 48(1):52-65. PubMed: 17071966 MGI: J:117480
Zabalawi M; Bhat S; Loughlin T; Thomas MJ; Alexander E; Cline M; Bullock B; Willingham M; Sorci-Thomas MG. 2003. Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol. Am J Pathol 163(3):1201-13. PubMed: 12937162 MGI: J:85174
Zaid A; Roubtsova A; Essalmani R; Marcinkiewicz J; Chamberland A; Hamelin J; Tremblay M; Jacques H; Jin W; Davignon J; Seidah NG; Prat A. 2008. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration. Hepatology 48(2):646-54. PubMed: 18666258 MGI: J:169834
Zernecke A; Bot I; Djalali-Talab Y; Shagdarsuren E; Bidzhekov K; Meiler S; Krohn R; Schober A; Sperandio M; Soehnlein O; Bornemann J; Tacke F; Biessen EA; Weber C. 2008. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res 102(2):209-17. PubMed: 17991882 MGI: J:145593
Zhang C; An J; Strickland DK; Yepes M. 2009. The low-density lipoprotein receptor-related protein 1 mediates tissue-type plasminogen activator-induced microglial activation in the ischemic brain. Am J Pathol 174(2):586-94. PubMed: 19147818 MGI: J:144185
Zhang D; Fang P; Jiang X; Nelson J; Moore JK; Kruger WD; Berretta RM; Houser SR; Yang X; Wang H. 2012. Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice. Circ Res 111(1):37-49. PubMed: 22628578 MGI: J:212656
Zhang WJ; Bird KE; McMillen TS; LeBoeuf RC; Hagen TM; Frei B. 2008. Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 117(3):421-8. PubMed: 18158360 MGI: J:145089
Zhang X; Thatcher SE; Rateri DL; Bruemmer D; Charnigo R; Daugherty A; Cassis LA. 2012. Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res 110(11):e73-85. PubMed: 22539767 MGI: J:212660
Zhang Y; Breevoort SR; Angdisen J; Fu M; Schmidt DR; Holmstrom SR; Kliewer SA; Mangelsdorf DJ; Schulman IG. 2012. Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest 122(5):1688-99. PubMed: 22484817 MGI: J:184536
Zhang Y; Wang X; Vales C; Lee FY; Lee H; Lusis AJ; Edwards PA. 2006. FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol 26(10):2316-21. PubMed: 16825595 MGI: J:128055
Zhao B; Song J; Chow WN; St Clair RW; Rudel LL; Ghosh S. 2007. Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr mice. J Clin Invest 117(10):2983-92. PubMed: 17885686 MGI: J:127535
Zhao L; Cuff CA; Moss E; Wille U; Cyrus T; Klein EA; Pratico D; Rader DJ; Hunter CA; Pure E; Funk CD. 2002. Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia. J Biol Chem 277(38):35350-6. PubMed: 12122008 MGI: J:79120
Zhao Y; Pennings M; Hildebrand RB; Ye D; Calpe-Berdiel L; Out R; Kjerrulf M; Hurt-Camejo E; Groen AK; Hoekstra M; Jessup W; Chimini G; Van Berkel TJ; Van Eck M. 2010. Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet. Circ Res 107(12):e20-31. PubMed: 21071707 MGI: J:178508
Zhao Y; Su B; Jacobs RL; Kennedy B; Francis GA; Waddington E; Brosnan JT; Vance JE; Vance DE. 2009. Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arterioscler Thromb Vasc Biol 29(9):1349-55. PubMed: 19520976 MGI: J:167813
Zhao Y; Ye D; Wang J; Calpe-Berdiel L; Azzis SB; Van Berkel TJ; Van Eck M. 2011. Stage-specific remodeling of atherosclerotic lesions upon cholesterol lowering in LDL receptor knockout mice. Am J Pathol 179(3):1522-32. PubMed: 21741939 MGI: J:179953
Zhou C; Pridgen B; King N; Xu J; Breslow JL. 2011. Hyperglycemic Ins2AkitaLdlr-/- mice show severely elevated lipid levels and increased atherosclerosis: a model of type 1 diabetic macrovascular disease. J Lipid Res 52(8):1483-93. PubMed: 21606463 MGI: J:174983
Zhou L; Choi HY; Li WP; Xu F; Herz J. 2009. LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. PLoS One 4(8):e6853. PubMed: 19718435 MGI: J:152391
Zhou L; Takayama Y; Boucher P; Tallquist MD; Herz J. 2009. LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One 4(9):e6922. PubMed: 19742316 MGI: J:153626
Zhou L; Yang H; Lin X; Okoro EU; Guo Z. 2012. Cholecystokinin elevates mouse plasma lipids. PLoS One 7(12):e51011. PubMed: 23300532 MGI: J:195734
Zhou L; Yang H; Okoro EU; Guo Z. 2014. Up-regulation of cholesterol absorption is a mechanism for cholecystokinin-induced hypercholesterolemia. J Biol Chem 289(19):12989-99. PubMed: 24692543 MGI: J:214128
Zhou Q; Mei Y; Shoji T; Han X; Kaminski K; Oh GT; Ongusaha PP; Zhang K; Schmitt H; Moser M; Bode C; Liao JK. 2012. Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis. Circulation 126(18):2236-47. PubMed: 23011471 MGI: J:210071
Zhou X; He W; Huang Z; Gotto AM Jr; Hajjar DP; Han J. 2008. Genetic deletion of low density lipoprotein receptor impairs sterol-induced mouse macrophage ABCA1 expression. A new SREBP1-dependent mechanism. J Biol Chem 283(4):2129-38. PubMed: 18029360 MGI: J:130725
Zhu L; Stalker TJ; Fong KP; Jiang H; Tran A; Crichton I; Lee EK; Neeves KB; Maloney SF; Kikutani H; Kumanogoh A; Pure E; Diamond SL; Brass LF. 2009. Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis. Arterioscler Thromb Vasc Biol 29(7):1039-45. PubMed: 19390055 MGI: J:167817
Zhu SN; Chen M; Jongstra-Bilen J; Cybulsky MI. 2009. GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions. J Exp Med 206(10):2141-9. PubMed: 19752185 MGI: J:153507
Zirlik A; Maier C; Gerdes N; MacFarlane L; Soosairajah J; Bavendiek U; Ahrens I; Ernst S; Bassler N; Missiou A; Patko Z; Aikawa M; Schonbeck U; Bode C; Libby P; Peter K. 2007. CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation 115(12):1571-80. PubMed: 17372166 MGI: J:133045
Zotes TM; Arias CF; Fuster JJ; Spada R; Perez-Yague S; Hirsch E; Wymann M; Carrera AC; Andres V; Barber DF. 2013. PI3K p110gamma deletion attenuates murine atherosclerosis by reducing macrophage proliferation but not polarization or apoptosis in lesions. PLoS One 8(8):e72674. PubMed: 23991137 MGI: J:204917
de Claro RA; Zhu X; Tang J; Morgan-Stevenson V; Schwartz BR; Iwata A; Liles WC; Raines EW; Harlan JM. 2011. Hematopoietic Fas Deficiency Does Not Affect Experimental Atherosclerotic Lesion Formation despite Inducing a Proatherogenic State. Am J Pathol 178(6):2931-7. PubMed: 21550016 MGI: J:173162
de Haan W; Out R; Berbee JF; van der Hoogt CC; van Dijk KW; van Berkel TJ; Romijn JA; Jukema JW; Havekes LM; Rensen PC. 2008. Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo. Biochem Biophys Res Commun 377(4):1294-8. PubMed: 18992221 MGI: J:143183
de Nooijer R; Bot I; von der Thusen JH; Leeuwenburgh MA; Overkleeft HS; Kraaijeveld AO; Dorland R; van Santbrink PJ; van Heiningen SH; Westra MM; Kovanen PT; Jukema JW; van der Wall EE; van Berkel TJ; Shi GP; Biessen EA. 2009. Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis. Arterioscler Thromb Vasc Biol 29(2):188-94. PubMed: 19095996 MGI: J:163799
de Oliveira J; Hort MA; Moreira EL; Glaser V; Ribeiro-do-Valle RM; Prediger RD; Farina M; Latini A; de Bem AF. 2011. Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress. Neuroscience 197:99-106. PubMed: 21945034 MGI: J:184047
de Souza JC; de Oliveira CA; Carneiro EM; Boschero AC; de Oliveira HC. 2010. Cholesterol toxicity in pancreatic islets from LDL receptor-deficient mice. Diabetologia 53(11):2461-2; author reply 2463-4. PubMed: 20694455 MGI: J:166652
van Dijk KW; van Vlijmen BJ; de Winther MP; van 't Hof B; van der Zee A; van der Boom H; Havekes LM; Hofker MH. 1999. Hyperlipidemia of ApoE2(Arg(158)-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression. Arterioscler Thromb Vasc Biol 19(12):2945-51. PubMed: 10591674 MGI: J:59826
van Eck M; Bos IS; Kaminski WE; Orso E; Rothe G; Twisk J; Bottcher A; Van Amersfoort ES; Christiansen-Weber TA; Fung-Leung WP; Van Berkel TJ; Schmitz G. 2002. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci U S A 99(9):6298-303. PubMed: 11972062 MGI: J:76337
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Ldlrtm1Her

Allele Symbol: Ldlrtm1Her

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Ldlrtm1Her related

Mammalian Phenotype Terms by Genotype

Genotype: Ldlrtm1Her/Ldlr+involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

homeostasis/metabolism phenotype

Genotype: Ldlrtm1Her/Ldlr+B6.129S7-Ldlrtm1Her

homeostasis/metabolism phenotype

Genotype: Ldlrtm1Her/Ldlrtm1Herinvolves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA

homeostasis/metabolism phenotype

Genotype: Ldlrtm1Her/Ldlrtm1Herinvolves: 129S7/SvEvBrd

homeostasis/metabolism phenotype

cardiovascular system phenotype

Genotype: Ldlrtm1Her/Ldlrtm1HerB6.129S7-Ldlrtm1Her

homeostasis/metabolism phenotype

adipose tissue phenotype

growth/size/body region phenotype

cardiovascular system phenotype

immune system phenotype

liver/biliary system phenotype

behavior/neurological phenotype

nervous system phenotype

hematopoietic system phenotype

Genotype: Ldlrtm1Her/Ldlrtm1Herinvolves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

cardiovascular system phenotype

homeostasis/metabolism phenotype

Genotype: Ldlrtm1Her/Ldlrtm1Herinvolves: 129S7/SvEvBrd * C57BL/6J

cardiovascular system phenotype

homeostasis/metabolism phenotype

Genotype: Ldlrtm1Her/Ldlrtm1HerB6.129S7-Ldlrtm1Her/J

homeostasis/metabolism phenotype

liver/biliary system phenotype

endocrine/exocrine gland phenotype

cardiovascular system phenotype

integument phenotype

Genotype: Ldlrtm1Her/Ldlrtm1Herinvolves: 129S7/SvEvBrd * C57BL/6

growth/size/body region phenotype

pigmentation phenotype

cellular phenotype

liver/biliary system phenotype

homeostasis/metabolism phenotype

nervous system phenotype

cardiovascular system phenotype

behavior/neurological phenotype

vision/eye phenotype

hematopoietic system phenotype

immune system phenotype

Genotype: Ldlrtm1Her/Ldlrtm1Herinvolves: 129S7/SvEvBrd * C57BL/6 * SJL

homeostasis/metabolism phenotype

References

Additional - Ldlrtm1Her related

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Ldlr^tm1Her

Allele Symbol: Ldlr^tm1Her

Genotype: Ldlr^tm1Her related

Genotype: Ldlr^tm1Her/Ldlr⁺
involves: 129S7/SvEvBrd * C57BL/6 * DBA/2

Genotype: Ldlr^tm1Her/Ldlr⁺
B6.129S7-Ldlr^tm1Her

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S7/SvEvBrd

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
B6.129S7-Ldlr^tm1Her

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S7/SvEvBrd * C57BL/6J

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
B6.129S7-Ldlr^tm1Her/J

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S7/SvEvBrd * C57BL/6

Genotype: Ldlr^tm1Her/Ldlr^tm1Her
involves: 129S7/SvEvBrd * C57BL/6 * SJL

Additional - Ldlr^tm1Her related