Thy1m&gamma;SN transgenic mice have the mouse thymus cell antigen 1 (Thy-1) promoter directing expression of the mouse &gamma;-synuclein (Sncg) gene. Homozygous Thy1m&gamma;SN mice are viable, fertile, and normal in size. They develop a clasping reflex, abnormal posture and gait, and other symptoms of motor dysfunction around 6 months of age, develop limb paralysis by 9 months of age, and die by 16 months of age. Homozygotes also show a 7-fold increase of &gamma;-synuclein mRNA in neurons compared with wild-type mice, leading to motor neuron impairment and premature death. Hemizygous mice develop this phenotype starting at 12 months of age. &gamma;-synuclein aggregates form fibrils, much like &alpha;-synuclein, aggregates of which have been associated with neurodegeneration in diseases such as Parkinson's disease. These mice may be useful for studying the pathophysiology of Parkinson's disease, and other neurodegenerative disorders.

Use of MICE only available to non-profit entities.

Thy1m&gamma;SN transgenic mice have the mouse thymus cell antigen 1 (Thy-1) promoter directing expression of the mouse &gamma;-synuclein (Sncg) gene. These mice may be useful for studying the pathophysiology of Parkinson's disease, and other neurodegenerative disorders.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

<a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> for more information.