Homozygote: Mice that are homozygous for the targeted mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Following subcutaneous innoculation with Leishmania mexicana, mutant mice exhibit larger lesions and greater parasite burdens than susceptible 129S4/SvJae controls. Although TH1/TH2 response is similar to control, mutant mice have elevated levels of IgM and IgG2a. This mutant mouse strain may be useful in studies of immune response.

Heterozygote: Not evaluated

Leishmania mexicana inoculated PD-L2 (programmed cell death 1, ligand 2) knockout mice exhibit larger lesions, greater parasite burdens than controls as well as elevated levels of IgM and IgG2a. This mutant mouse strain may be useful in studies of immune response.

This strain is hosted by NIH's MMRRC, which partners with JAX for the distribution of this and other strains. For additional information and to purchase, please visit the MMRRC site.