Mice both homozygous for the wblo mutation and homozygous or hemizyogus for the Glatm1Kul mutation develop a wobbly gait by approximately 5 weeks of age that decreases in severity with age.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Gla | galactosidase, alpha |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Itpr1 | inositol 1,4,5-trisphosphate receptor 1 |
Mice both homozygous for the wblo mutation and homozygous or hemizyogus for the Glatm1Kul mutation develop a wobbly gait by approximately 5 weeks of age that decreases in severity with age.
The wblo mutation arose spontaneously in the homozyogus strain B6;129-Glatm1Kul/J. One backcross to C57BL/6J was done and then the offspring were sibling intercrossed. The resulting strain is still homozygous for the X-linked Glatm1Kul mutation and maintained segregating for the recessive wblo mutation.
Allele Name | targeted mutation 1, Ashok B Kulkarni |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | alpha-Gal A -/0; alpha-galA-; Gla- |
Gene Symbol and Name | Gla, galactosidase, alpha |
Gene Synonym(s) | |
Strain of Origin | 129S4/SvJae |
Chromosome | X |
Molecular Note | A 1kb genomic fragment containing part of exon 3 and intron 3 was replaced by a neomycin resistance cassette. |
Mutations Made By | Ashok Kulkarni, NIDCR NIH |
Allele Name | wobbly locomotion |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Itpr1, inositol 1,4,5-trisphosphate receptor 1 |
Gene Synonym(s) | |
Strain of Origin | B6;129-Glatm1Kul/J |
Chromosome | 6 |
Molecular Note | This spontaneous mutation was identified at The Jackson Laboratory. The molecular lesion is a G-to-A mutation at coding nucleotide 1166 of the cDNA (NM_010585) which alters an arginine to a histidine at position 389 of the encoded protein (p.R389H). |
When using the B6;129-Glatm1Kul Itpr1wblo/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #012625 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous females and Hemizygous males for Gla<tm1Kul> , Heterozygous or Homozygous for wblo, 1 pair minimum |
Frozen Mouse Embryo | B6;129-Gla<tm1Kul> Itpr1<wblo>/GrsrJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6;129-Gla<tm1Kul> Itpr1<wblo>/GrsrJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6;129-Gla<tm1Kul> Itpr1<wblo>/GrsrJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6;129-Gla<tm1Kul> Itpr1<wblo>/GrsrJ Frozen Embryos | $3373.50 |
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