JAX
Mouse Strain Datasheet - 012620
STOCK Trp53tm1Brd Brca1tm1Aash Tg(LGB-cre)74Acl/J
Also Known As: BLG-Cre; Brca1F22-24; p53 KO, BLG-Cre; Brca1F22-24/F22-24; p53+/-
These mice carry the beta-lactoglobulin Cre (BLG-Cre) transgene, are homozygous for floxed exons 22-24 of the breast cancer 1 (Brca1) allele, and are heterozygous for p53 tumor-suppressor gene (Trp53) deficiency. This strain may be useful for studying human basal-like cancer and breast cancer, as well as providing a useful tool for testing new therapeutics.
Donating Investigator
Afshan McCarthy, The Breakthrough Toby Robins Breast Canc
Genetic overview
| Genetic Background | Generation |
|---|---|
|
F?+F18
|
Brca1tm1Aash
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Conditional ready (e.g. floxed), No functional change) | Brca1 | breast cancer 1, early onset |
Tg(LGB-cre)74Acl
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Trp53tm1Brd
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Trp53 | transformation related protein 53 |
Research Applications
- Cancer Research
- Endocrine Deficiency Research
- Neurobiology Research
- Research Tools
Base Price
Starting at:
| $263.00 Domestic price for female |
| $526.00 Domestic price for breeder pair |
Important Note
To induce the tumor development in these mice, the donating investigator reports that BLG-Cre; Brca1tm1Aash; Trp53+/- mice should be allowed to go through two rounds of pregnancy and then set aside to allow Cre activation and the loss of Brca1 function.
Detailed Description
BLG-Cre; Brca1tm1Aash; Trp53+/- mice that carry the beta-lactoglobulin Cre (BLG-Cre) transgene are homozygous for floxed exons 22-24 of the breast cancer 1 (Brca1) allele, and are heterozygous for p53 tumor-suppressor gene (Trp53) deficiency. Mice of this genotype are viable, fertile, normal in size and do not display any behavioral abnormalities. BLG-Cre; Brca1tm1Aash; Trp53+/- females have expression of the BLG-Cre transgene during lactation; which leads to loss of Brca1 function in the mammary gland. This results in formation of mammary tumors exhibiting high grade central necrosis and metaplastic elements in the form of spindle cell and squamous cell differentiation; as seen in human basal-like breast cancers and BRCA1 mutation carriers. Heterozygosity for the mutant p53 allele accelerates the formation of mammary tumors. This strain may be useful for studying human basal-like cancer and breast cancer, as well as providing a useful tool for testing new therapeutics.
Development
This mouse colony harbors three mutations: a p53- mutation, the Brca1F22-24 mutation, and a BLG-Cre transgene. The description of each is below.
To generate the p53 mutant allele, a targeting vector was designed to replace part of exon 5 of the mouse p53 tumor-suppressor gene, p53, with a PolII-neomycin (neo) resistance cassette (Harvey et al, Nat Gen, 1993; 5; 225-29). This construct was electroporated into 129S7/SvEvBrd-Hprt1+-derived AB1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts and the resulting chimeric males were bred to C57BL/6 females. These mice were intercrossed to establish a colony of p53 transgenic mice.
To generate the Brca1F22-24 mutant allele, a targeting vector was designed by Dr. Alan Ashworth (Breakthrough Breast Cancer Research Centre, London) to replace exons 22-24 of the mouse breast cancer 1 gene (Brca1) with a loxP site, a cDNA sequence encoded by exons 22-24, a 3' myc epitope, bovine growth hormone polyA signal, a second loxP site, a splice acceptor sequence, and a PGK-neo cassette. This construct was electroporated into (129X1/SvJ x 129S1/Sv)F1-Kitl+-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts and the resulting chimeric mice were bred to C57BL/6 mice. These mice were intercrossed to establish a colony of Brca1F22-24/F22-24 mice on a mixed background.
The BLG-Cre transgene was designed by Dr. Alan R. Clarke (while at University Medical School, Edinburgh, United Kingdom) to have Cre recombinase under the control of the sheep mammary gland specific promoter of the ovine beta-lactoglobulin (BLG) gene. The construct included exon 1 of sheep BLG, and a Cre recombinase with a modified initiation codon and a polyadenylation signal (polyA). The construct was microinjected into the pronuclei of (CBA x C57BL/6) fertilized oocytes, and mice from founder line 74 were identified and bred to C57BL/6 mice. These mice were intercrossed to establish a colony of BLG-cre mice on a mixed background.
Mutant mice were bred together to generate the triple mutant colony. Mice heterozygous for the p53 allele, homozygous for the floxed Brca1 allele (Brca1F22-24/F22-24), and hemizygous for the BLG-cre transgene (also called BLG-Cre; Brca1F22-24/F22-24; p53+/- mice) were maintained on a mixed genetic background prior to sending to The Jackson Laboratory Repository. Upon arrival, mice were bred to C57BL/6J inbred mice (Stock No. 000664) for at least one generation to establish the colony.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | Cre recombinase is active in the mammary gland. |
| Site of Expression | Normal Trp53 expression is widespread. |
Control Suggestions
Selected References
- McCarthy A; Savage K; Gabriel A; Naceur C; Reis-Filho JS; Ashworth A. 2007. A mouse model of basal-like breast carcinoma with metaplastic elements. J Pathol 211(4):389-98. PubMed: 17212342MGI: J:119996
Brca1tm1Aash
Allele Symbol: Brca1tm1Aash
| Allele Name | targeted mutation 1, Alan Ashworth |
|---|---|
| Allele Type | Targeted (Conditional ready (e.g. floxed), No functional change) |
| Allele Synonym(s) | Brca1F22-24 |
| Gene Symbol and Name | Brca1, breast cancer 1, early onset |
| Gene Synonym(s) | BRCAI; BRCC1; BROVCA1; FANCS; IRIS; PNCA4; PPP1R53; PSCP; RNF53 |
| Site of Expression | mammary epithelial cells |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Chromosome | 11 |
| Molecular Note | Exons 22-24 were replaced with a floxed sequence containing cDNA for exons 22-24 with an in frame myc epitope and a bovine growth hormone poly A sequence. This vector allows conditional excision of the second, terminal BRCT domain. Downstream of the floxed sequence, a splice acceptor and PGK-neo were inserted. |
| Mutations Made By | Alan Ashworth, The Breakthrough Toby Robins Breast canc |
Tg(LGB-cre)74Acl
Allele Symbol: Tg(LGB-cre)74Acl
| Allele Name | transgene insertion 74, Alan R Clarke |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | BLG-Cre; Blg-CreTg |
| Gene Symbol and Name | Tg(LGB-cre)74Acl, transgene insertion 74, Alan R Clarke |
| Gene Synonym(s) | BLG-Cre; Blg-CreTg |
| Promoter | LGB, beta-lactoglobulin, sheep |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | Cre recombinase is active in the mammary gland. |
| Strain of Origin | (CBA x C57BL/6) |
| Chromosome | UN |
| Molecular Note | This transgene expresses Cre recombinase under the control of a sheep beta-lactoglobulin promoter (LGB), active in the mammary gland. |
| Mutations Made By | Alan Clarke, University Medical School, Edinburgh, Un |
Trp53tm1Brd
Allele Symbol: Trp53tm1Brd
| Allele Name | targeted mutation 1, Allan Bradley |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | P-; TSG-p53; Trp53-; Trp53N; Trp53delta; p53-; p53N |
| Gene Symbol and Name | Trp53, transformation related protein 53 |
| Gene Synonym(s) | BCC7; LFS1; P53; TRP53; p44; p53 |
| Site of Expression | Normal Trp53 expression is widespread. |
| Strain of Origin | 129S7/SvEvBrd-Hprt<+> |
| Chromosome | 11 |
| Molecular Note | A PolII-neomycin resistance cassette which lacked a polyadenylation signal was inserted into exon 5 of the gene. The insertion was accompanied by a small deletion of a 450 bp fragment containing 106 nucleotides of exon 5 and 350 nucleotides of intron 4. |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Cancer Research
- Increased Tumor Incidence
- Mammary Gland Tumors
- Mammary Gland Tumors: females only
- Other
- tumor metastasis
- Increased Tumor Incidence
- Endocrine Deficiency Research
- Mammary Gland Defects
- Neurobiology Research
- Cre-lox System
- loxP-flanked Sequences
- Cre-lox System
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Developmental Biology Research
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Reproductive Biology Research
- Cre-lox System
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
Mammalian Phenotype Terms by Genotype
Genotype: Brca1tm1Aash/Brca1tm1Aash Trp53tm1Brd/Trp53+ Tg(LGB-cre)74Acl/0
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA
digestive/alimentary phenotype
- increased salivary adenocarcinoma incidence
- some (2/59) develop salivary gland malignant myoepithelial tumors (MGI Ref ID J:119996)
neoplasm
- increased mammary gland ductal carcinoma incidence
- high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumorsissue in a few tumors (MGI Ref ID J:119996)
- increased mammary gland tumor incidence
- majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32) (MGI Ref ID J:119996)
- mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands (MGI Ref ID J:119996)
- most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate (MGI Ref ID J:119996)
- most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation (MGI Ref ID J:119996)
- tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body (MGI Ref ID J:119996)
- increased salivary adenocarcinoma incidence
- some (2/59) develop salivary gland malignant myoepithelial tumors (MGI Ref ID J:119996)
endocrine/exocrine gland phenotype
- abnormal mammary gland development
- only 2/33 tumors show beta-catenin upregulation that was restricted to areas of squamous differentiation and basaloid cells (MGI Ref ID J:119996)
- increased mammary gland ductal carcinoma incidence
- high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumorsissue in a few tumors (MGI Ref ID J:119996)
- increased mammary gland tumor incidence
- majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32) (MGI Ref ID J:119996)
- mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands (MGI Ref ID J:119996)
- most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate (MGI Ref ID J:119996)
- most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation (MGI Ref ID J:119996)
- tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body (MGI Ref ID J:119996)
- increased salivary adenocarcinoma incidence
- some (2/59) develop salivary gland malignant myoepithelial tumors (MGI Ref ID J:119996)
integument phenotype
- abnormal mammary gland development
- only 2/33 tumors show beta-catenin upregulation that was restricted to areas of squamous differentiation and basaloid cells (MGI Ref ID J:119996)
- increased mammary gland ductal carcinoma incidence
- high grade ductal carcinoma in situ (DCIS) is observed admixed with, or adjacent to, the invasive tumor in some cases, and occasionally columnar cell lesions with cytological atypia are seen with those tumors; columnar cell changes are found in adjacent tissue in a few tumorsissue in a few tumors (MGI Ref ID J:119996)
- increased mammary gland tumor incidence
- majority of tumors (30/33) show marked nuclear pleomorphism; central necrosis is seen in about 67% of tumors (23/32) (MGI Ref ID J:119996)
- mice develop mammary gland tumors with higher frequency (64%; 25/39 animals) and shorter latency of 6-46 weeks (all but one tumor had developed by 31 weeks) relative to control mice; 6/39 mice had multiple tumors in the same and in adjacent glands (MGI Ref ID J:119996)
- most (29/33) neoplasms show mixed pushing and infiltrative borders, while only 4/33 showed a prominent inflammatory infiltrate (MGI Ref ID J:119996)
- most (29/33) tumors show homologous metaplastic elements in form of squamous or spindly differentiation (MGI Ref ID J:119996)
- tumors develop in the inguinal and thoracic glands with equal frequency, and on both sides of the body (MGI Ref ID J:119996)
References
- McCarthy A; Savage K; Gabriel A; Naceur C; Reis-Filho JS; Ashworth A. 2007. A mouse model of basal-like breast carcinoma with metaplastic elements. J Pathol 211(4):389-98. PubMed: 17212342MGI: J:119996
Additional - Brca1tm1Aash related
- Huang HS; Chu SC; Hsu CF; Chen PC; Ding DC; Chang MY; Chu TY. 2015. Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis. Carcinogenesis 36(11):1419-28. PubMed: 26363031MGI: J:226629
- Mgbemena VE; Signer RA; Wijayatunge R; Laxson T; Morrison SJ; Ross TS. 2017. Distinct Brca1 Mutations Differentially Reduce Hematopoietic Stem Cell Function. Cell Rep 18(4):947-960. PubMed: 28122244MGI: J:240315
- Molyneux G; Geyer FC; Magnay FA; McCarthy A; Kendrick H; Natrajan R; Mackay A; Grigoriadis A; Tutt A; Ashworth A; Reis-Filho JS; Smalley MJ. 2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7(3):403-17. PubMed: 20804975MGI: J:164435
- Vasanthakumar A; Arnovitz S; Marquez R; Lepore J; Rafidi G; Asom A; Weatherly M; Davis EM; Neistadt B; Duszynski R; Vardiman JW; Le Beau MM; Godley LA; Churpek JE. 2016. Brca1 deficiency causes bone marrow failure and spontaneous hematologic malignancies in mice. Blood 127(3):310-3. PubMed: 26644450MGI: J:231547
- Zhang Z; Christin JR; Wang C; Ge K; Oktay MH; Guo W. 2016. Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation. Cell Rep 16(12):3146-56. PubMed: 27653681MGI: J:239126
Additional - Trp53tm1Brd related
- Adam J; Deans B; Thacker J. 2007. A role for Xrcc2 in the early stages of mouse development. DNA Repair (Amst) 6(2):224-34. PubMed: 17116431MGI: J:120961
- Akhtar RS; Geng Y; Klocke BJ; Latham CB; Villunger A; Michalak EM; Strasser A; Carroll SL; Roth KA. 2006. BH3-only proapoptotic Bcl-2 family members Noxa and Puma mediate neural precursor cell death. J Neurosci 26(27):7257-64. PubMed: 16822983MGI: J:110228
- Akhtar RS; Geng Y; Klocke BJ; Roth KA. 2006. Neural precursor cells possess multiple p53-dependent apoptotic pathways. Cell Death Differ 13(10):1727-39. PubMed: 16514420MGI: J:126291
- Akli S; Van Pelt CS; Bui T; Meijer L; Keyomarsi K. 2011. Cdk2 is Required for Breast Cancer Mediated by the Low-Molecular-Weight Isoform of Cyclin E. Cancer Res 71(9):3377-86. PubMed: 21385896MGI: J:171726
- Akli S; Van Pelt CS; Bui T; Multani AS; Chang S; Johnson D; Tucker S; Keyomarsi K. 2007. Overexpression of the low molecular weight cyclin E in transgenic mice induces metastatic mammary carcinomas through the disruption of the ARF-p53 pathway. Cancer Res 67(15):7212-22. PubMed: 17671189MGI: J:123914
- Alexander BM; Van Kirk EA; Naughton LM; Murdoch WJ. 2007. Ovarian morphometrics in TP53-deficient mice. Anat Rec (Hoboken) 290(1):59-64. PubMed: 17441198MGI: J:174177
- Allen SM; Florell SR; Hanks AN; Alexander A; Diedrich MJ; Altieri DC; Grossman D. 2003. Survivin expression in mouse skin prevents papilloma regression and promotes chemical-induced tumor progression. Cancer Res 63(3):567-72. PubMed: 12566297MGI: J:81530
- Amleh A; Nair SJ; Sun J; Sutherland A; Hasty P; Li R. 2009. Mouse cofactor of BRCA1 (Cobra1) is required for early embryogenesis. PLoS One 4(4):e5034. PubMed: 19340312MGI: J:148508
- Amson R; Lassalle JM; Halley H; Prieur S; Lethrosne F; Roperch JP; Israeli D; Gendron MC; Duyckaerts C; Checler F; Dausset J; Cohen D; Oren M; Telerman A. 2000. Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient mice. Proc Natl Acad Sci U S A 97(10):5346-50. PubMed: 10805794MGI: J:111370
- An JY; Kim EA; Jiang Y; Zakrzewska A; Kim DE; Lee MJ; Mook-Jung I; Zhang Y; Kwon YT. 2010. UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination. Proc Natl Acad Sci U S A 107(5):1912-7. PubMed: 20080676MGI: J:157596
- Antonini D; Russo MT; De Rosa L; Gorrese M; Del Vecchio L; Missero C. 2010. Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells. J Invest Dermatol 130(5):1249-57. PubMed: 20090763MGI: J:159929
- Armata HL; Garlick DS; Sluss HK. 2007. The ataxia telangiectasia-mutated target site Ser18 is required for p53-mediated tumor suppression. Cancer Res 67(24):11696-703. PubMed: 18089799MGI: J:130855
- Armata HL; Golebiowski D; Jung DY; Ko HJ; Kim JK; Sluss HK. 2010. Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis. Mol Cell Biol 30(24):5787-94. PubMed: 20956556MGI: J:191181
- Armata HL; Shroff P; Garlick DE; Penta K; Tapper AR; Sluss HK. 2011. Loss of p53 Ser18 and Atm results in embryonic lethality without cooperation in tumorigenesis. PLoS One 6(9):e24813. PubMed: 21980358MGI: J:191179
- Aubrecht J; Secretan MB; Bishop AJ; Schiestl RH. 1999. Involvement of p53 in X-ray induced intrachromosomal recombination in mice. Carcinogenesis 20(12):2229-36. PubMed: 10590213MGI: J:59211
- Babbe H; Chester N; Leder P; Reizis B. 2007. The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol 27(5):1947-59. PubMed: 17210642MGI: J:118992
- Babbe H; McMenamin J; Hobeika E; Wang J; Rodig SJ; Reth M; Leder P. 2009. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol 182(1):347-60. PubMed: 19109166MGI: J:142894
- Bachelier R; Xu X; Li C; Qiao W; Furth PA; Lubet RA; Deng CX. 2005. Effect of bilateral oophorectomy on mammary tumor formation in BRCA1 mutant mice. Oncol Rep 14(5):1117-20. PubMed: 16211273MGI: J:103868
- Bachelier R; Xu X; Wang X; Li W; Naramura M; Gu H; Deng CX. 2003. Normal lymphocyte development and thymic lymphoma formation in Brca1 exon-11-deficient mice. Oncogene 22(4):528-37. PubMed: 12555066MGI: J:81541
- Bae BI; Xu H; Igarashi S; Fujimuro M; Agrawal N; Taya Y; Hayward SD; Moran TH; Montell C; Ross CA; Snyder SH; Sawa A. 2005. p53 Mediates Cellular Dysfunction and Behavioral Abnormalities in Huntington's Disease. Neuron 47(1):29-41. PubMed: 15996546MGI: J:99630
- Bagchi A; Papazoglu C; Wu Y; Capurso D; Brodt M; Francis D; Bredel M; Vogel H; Mills AA. 2007. CHD5 is a tumor suppressor at human 1p36. Cell 128(3):459-75. PubMed: 17289567MGI: J:121726
- Bagchi D; Balmoori J; Bagchi M; Ye X; Williams CB; Stohs SJ. 2000. Role of p53 tumor suppressor gene in the toxicity of TCDD, endrin, naphthalene, and chromium (vi) in liver and brain tissues of mice Free Radic Biol Med 28(6):895-903. PubMed: 10802220MGI: J:62442
- Bailey SL; Gurley KE; Hoon-Kim K; Kelly-Spratt KS; Kemp CJ. 2008. Tumor suppression by p53 in the absence of Atm. Mol Cancer Res 6(7):1185-92. PubMed: 18583527MGI: J:139874
- Bajenaru ML; Donahoe J; Corral T; Reilly KM; Brophy S; Pellicer A; Gutmann DH. 2001. Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia 33(4):314-23. PubMed: 11246230MGI: J:80411
- Balboni AL; Hutchinson JA; DeCastro AJ; Cherukuri P; Liby K; Sporn MB; Schwartz GN; Wells WA; Sempere LF; Yu PB; DiRenzo J. 2013. DeltaNp63alpha-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res 73(2):1020-30. PubMed: 23243027MGI: J:194364
- Barazzone C; Horowitz S; Donati YR; Rodriguez I; Piguet PF. 1998. Oxygen toxicity in mouse lung: pathways to cell death. Am J Respir Cell Mol Biol 19(4):573-81. PubMed: 9761753MGI: J:51593
- Barlow JL; Drynan LF; Hewett DR; Holmes LR; Lorenzo-Abalde S; Lane AL; Jolin HE; Pannell R; Middleton AJ; Wong SH; Warren AJ; Wainscoat JS; Boultwood J; McKenzie AN. 2010. A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. Nat Med 16(1):59-66. PubMed: 19966810MGI: J:155870
- Barrington RE; Subler MA; Rands E; Omer CA; Miller PJ; Hundley JE; Koester SK; Troyer DA; Bearss DJ; Conner MW; Gibbs JB; Hamilton K; Koblan KS; Mosser SD; O'Neill TJ; Schaber MD; Senderak ET; Windle JJ; Oliff A; Kohl NE. 1998. A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Mol Cell Biol 18(1):85-92. PubMed: 9418856MGI: J:78608
- Bassing CH; Ranganath S; Murphy M; Savic V; Gleason M; Alt FW. 2008. Aberrant V(D)J recombination is not required for rapid development of H2ax/p53-deficient thymic lymphomas with clonal translocations. Blood 111(4):2163-9. PubMed: 17855626MGI: J:131202
- Bassing CH; Suh H; Ferguson DO; Chua KF; Manis J; Eckersdorff M; Gleason M; Bronson R; Lee C; Alt FW. 2003. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114(3):359-70. PubMed: 12914700MGI: J:84879
- Baxter EW; Blyth K; Donehower LA; Cameron ER; Onions DE; Neil JC. 1996. Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development? J Virol 70(4):2095-100. PubMed: 8642629MGI: J:93778
- Beer S; Zetterberg A; Ihrie RA; McTaggart RA; Yang Q; Bradon N; Arvanitis C; Attardi LD; Feng S; Ruebner B; Cardiff RD; Felsher DW. 2004. Developmental Context Determines Latency of MYC-Induced Tumorigenesis. PLoS Biol 2(11):E332. PubMed: 15455033MGI: J:93372
- Behesti H; Bhagat H; Dubuc AM; Taylor MD; Marino S. 2013. Bmi1 overexpression in the cerebellar granule cell lineage of mice affects cell proliferation and survival without initiating medulloblastoma formation. Dis Model Mech 6(1):49-63. PubMed: 23065639MGI: J:193730
- Berton TR; Mitchell DL; Guo R; Johnson DG. 2005. Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation. Oncogene 24(15):2449-60. PubMed: 15735727MGI: J:97525
- Bhandoola A; Dolnick B; Fayad N; Nussenzweig A; Singer A. 2000. Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. J Exp Med 192(6):891-7. PubMed: 10993919MGI: J:112013
- Bianchetta MJ; Lam TT; Jones SN; Morabito MA. 2011. Cyclin-dependent kinase 5 regulates PSD-95 ubiquitination in neurons. J Neurosci 31(33):12029-35. PubMed: 21849563MGI: J:176050
- Biggs PJ; Vogel H; Sage M; Martin LA; Donehower LA; Bradley A. 2003. Allelic phasing of a mouse chromosome 11 deficiency influences p53 tumorigenicity. Oncogene 22(21):3288-96. PubMed: 12761499MGI: J:83780
- Billington CJ Jr; Ng B; Forsman C; Schmidt B; Bagchi A; Symer DE; Schotta G; Gopalakrishnan R; Sarver AL; Petryk A. 2011. The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice. Dev Biol 355(1):21-31. PubMed: 21549111MGI: J:173627
- Bishop AJ; Hollander MC; Kosaras B; Sidman RL; Fornace AJ Jr; Schiestl RH. 2003. Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development. Cancer Res 63(17):5335-43. PubMed: 14500365MGI: J:85514
- Blyth K; Terry A; O'Hara M; Baxter EW; Campbell M; Stewart M; Donehower LA; Onions DE; Neil JC; Cameron ER. 1995. Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss. Oncogene 10(9):1717-23. PubMed: 7753548MGI: J:75383
- Blyth K; Vaillant F; Hanlon L; Mackay N; Bell M; Jenkins A; Neil JC; Cameron ER. 2006. Runx2 and MYC collaborate in lymphoma development by suppressing apoptotic and growth arrest pathways in vivo. Cancer Res 66(4):2195-201. PubMed: 16489021MGI: J:106649
- Boehme SA; Lenardo MJ. 1996. TCR-mediated death of mature T lymphocytes occurs in the absence of p53. J Immunol 156(11):4075-8. PubMed: 8666771MGI: J:110825
- Bogue MA; Zhu C; Aguilar-Cordova E; Donehower LA; Roth DB. 1996. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes. Genes Dev 10(5):553-65. PubMed: 8598286MGI: J:31868
- Bohgaki T; Bohgaki M; Cardoso R; Panier S; Zeegers D; Li L; Stewart GS; Sanchez O; Hande MP; Durocher D; Hakem A; Hakem R. 2011. Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. PLoS Genet 7(4):e1001381. PubMed: 21552324MGI: J:198260
- Bouffler SD; Kemp CJ; Balmain A; Cox R. 1995. Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice. Cancer Res 55(17):3883-9. PubMed: 7641208MGI: J:28444
- Braig M; Lee S; Loddenkemper C; Rudolph C; Peters AH; Schlegelberger B; Stein H; Dorken B; Jenuwein T; Schmitt CA. 2005. Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436(7051):660-5. PubMed: 16079837MGI: J:100109
- Brianna Caddle L; Grant JL; Szatkiewicz J; van Hase J; Shirley BJ; Bewersdorf J; Cremer C; Arneodo A; Khalil A; Mills KD. 2007. Chromosome neighborhood composition determines translocation outcomes after exposure to high-dose radiation in primary cells. Chromosome Res 15(8):1061-73. PubMed: 18060570MGI: J:130472
- Brightbill H; Schlissel MS. 2009. The effects of c-Abl mutation on developing B cell differentiation and survival. Int Immunol 21(5):575-85. PubMed: 19299624MGI: J:148105
- Broccoli D; Godley LA; Donehower LA; Varmus HE; de Lange T. 1996. Telomerase activation in mouse mammary tumors: lack of detectable telomere shortening and evidence for regulation of telomerase RNA with cell proliferation. Mol Cell Biol 16(7):3765-72. PubMed: 8668193MGI: J:71575
- Brodie SG; Xu X; Li C; Kuo A; Leder P; Deng CX. 2001. Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis. Oncogene 20(12):1445-54. PubMed: 11313888MGI: J:69223
- Brodie SG; Xu X; Qiao W; Li WM; Cao L; Deng CX. 2001. Multiple genetic changes are associated with mammary tumorigenesis in Brca1 conditional knockout mice. Oncogene 20(51):7514-23. PubMed: 11709723MGI: J:72815
- Brosh R; Assia-Alroy Y; Molchadsky A; Bornstein C; Dekel E; Madar S; Shetzer Y; Rivlin N; Goldfinger N; Sarig R; Rotter V. 2013. p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition. Cell Death Differ 20(2):312-20. PubMed: 22996684MGI: J:205627
- Bruggeman SW; Valk-Lingbeek ME; van der Stoop PP; Jacobs JJ; Kieboom K; Tanger E; Hulsman D; Leung C; Arsenijevic Y; Marino S; van Lohuizen M. 2005. Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice. Genes Dev 19(12):1438-43. PubMed: 15964995MGI: J:105559
- Buettner VL; Hill KA; Nishino H; Schaid DJ; Frisk CS; Sommer SS. 1996. Increased mutation frequency and altered spectrum in one of four thymic lymphomas derived from tumor prone p53/Big Blue double transgenic mice. Oncogene 13(11):2407-13. PubMed: 8957082MGI: J:90313
- Bulavin DV; Phillips C; Nannenga B; Timofeev O; Donehower LA; Anderson CW; Appella E; Fornace AJ Jr. 2004. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway. Nat Genet 36(4):343-50. PubMed: 14991053MGI: J:121570
- Burds AA; Lutum AS; Sorger PK. 2005. Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc Natl Acad Sci U S A 102(32):11296-301. PubMed: 16055552MGI: J:100464
- Burga LN; Hu H; Juvekar A; Tung NM; Troyan SL; Hofstatter EW; Wulf GM. 2011. Loss of BRCA1 leads to an increase in epidermal growth factor receptor expression in mammary epithelial cells, and epidermal growth factor receptor inhibition prevents estrogen receptor-negative cancers in BRCA1-mutant mice. Breast Cancer Res 13(2):R30. PubMed: 21396117MGI: J:175588
- Burr KL; Smith AG; Dubrova YE. 2005. p53 deficiency does not affect mutation rate in the mouse germline. Oncogene 24(26):4315-8. PubMed: 15806156MGI: J:99550
- Busch SE; Gurley KE; Moser RD; Kemp CJ. 2012. ARF suppresses hepatic vascular neoplasia in a carcinogen-exposed murine model. J Pathol 227(3):298-305. PubMed: 22430984MGI: J:185457
- Caddle LB; Hasham MG; Schott WH; Shirley BJ; Mills KD. 2008. Homologous recombination is necessary for normal lymphocyte development. Mol Cell Biol 28(7):2295-303. PubMed: 18212067MGI: J:134209
- Cai Q; Dmitrieva NI; Ferraris JD; Michea LF; Salvador JM; Hollander MC; Fornace AJ Jr; Fenton RA; Burg MB. 2006. Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells. Am J Physiol Renal Physiol 291(2):F341-9. PubMed: 16597604MGI: J:110650
- Callen E; Jankovic M; Wong N; Zha S; Chen HT; Difilippantonio S; Di Virgilio M; Heidkamp G; Alt FW; Nussenzweig A; Nussenzweig M. 2009. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Mol Cell 34(3):285-97. PubMed: 19450527MGI: J:150435
- Cano A; Gamallo C; Kemp CJ; Benito N; Palacios J; Quintanilla M; Balmain A. 1996. Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice. Int J Cancer 65(2):254-62. PubMed: 8567126MGI: J:101805
- Cao L; Kim S; Xiao C; Wang RH; Coumoul X; Wang X; Li WM; Xu XL; De Soto JA; Takai H; Mai S; Elledge SJ; Motoyama N; Deng CX. 2006. ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. EMBO J 25(10):2167-77. PubMed: 16675955MGI: J:108783
- Cao L; Li W; Kim S; Brodie SG; Deng CX. 2003. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev 17(2):201-13. PubMed: 12533509MGI: J:81559
- Cao L; Xu X; Bunting SF; Liu J; Wang RH; Cao LL; Wu JJ; Peng TN; Chen J; Nussenzweig A; Deng CX; Finkel T. 2009. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell 35(4):534-41. PubMed: 19716796MGI: J:154193
- Cao L; Xu X; Cao LL; Wang RH; Coumoul X; Kim SS; Deng CX. 2007. Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach. Carcinogenesis 28(7):1401-7. PubMed: 17363841MGI: J:122899
- Carmichael NG; Debruyne EL; Bigot-Lasserre D. 2000. The p53 heterozygous knockout mouse as a model for chemical carcinogenesis in vascular tissue Environ Health Perspect 108(1):61-5. PubMed: 10620525MGI: J:60035
- Carstens MJ; Krempler A; Triplett AA; Van Lohuizen M; Wagner KU. 2004. Cell cycle arrest and cell death are controlled by p53-dependent and p53-independent mechanisms in Tsg101-deficient cells. J Biol Chem 279(34):35984-94. PubMed: 15210712MGI: J:92528
- Celeste A; Difilippantonio S; Difilippantonio MJ; Fernandez-Capetillo O; Pilch DR; Sedelnikova OA; Eckhaus M; Ried T; Bonner WM; Nussenzweig A. 2003. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell 114(3):371-83. PubMed: 12914701MGI: J:86590
- Cellurale C; Sabio G; Kennedy NJ; Das M; Barlow M; Sandy P; Jacks T; Davis RJ. 2011. Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation. Mol Cell Biol 31(7):1565-76. PubMed: 21282468MGI: J:170101
- Chan LH; Wang W; Yeung W; Deng Y; Yuan P; Mak KK. 2014. Hedgehog signaling induces osteosarcoma development through Yap1 and H19 overexpression. Oncogene 33(40):4857-66. PubMed: 24141783MGI: J:214349
- Chandrasekaran Y; Richburg JH. 2005. The p53 protein influences the sensitivity of testicular germ cells to mono-(2-ethylhexyl) phthalate-induced apoptosis by increasing the membrane levels of Fas and DR5 and decreasing the intracellular amount of c-FLIP. Biol Reprod 72(1):206-13. PubMed: 15371270MGI: J:115452
- Chang WC; Coudry RA; Clapper ML; Zhang X; Williams KL; Spittle CS; Li T; Cooper HS. 2007. Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium. Carcinogenesis 28(11):2375-81. PubMed: 17557903MGI: J:126538
- Chen CS; Squire JA; Wells PG. 2009. Reduced tumorigenesis in p53 knockout mice exposed in utero to low-dose vitamin E. Cancer 115(7):1563-75. PubMed: 19195043MGI: J:151126
- Chen CS; Wells PG. 2006. Enhanced tumorigenesis in p53 knockout mice exposed in utero to high-dose vitamin E. Carcinogenesis 27(7):1358-68. PubMed: 16401638MGI: J:112086
- Cheo DL; Burns DK; Meira LB; Houle JF; Friedberg EC. 1999. Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. Cancer Res 59(4):771-5. PubMed: 10029060MGI: J:52823
- Cheung AM; Elia A; Tsao MS; Done S; Wagner KU; Hennighausen L; Hakem R; Mak TW. 2004. Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice. Cancer Res 64(6):1959-65. PubMed: 15026330MGI: J:89150
- Cheung AM; Hande MP; Jalali F; Tsao MS; Skinnider B; Hirao A; McPherson JP; Karaskova J; Suzuki A; Wakeham A; You-Ten A; Elia A; Squire J; Bristow R; Hakem R; Mak TW. 2002. Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis. Cancer Res 62(21):6194-204. PubMed: 12414647MGI: J:79697
- Cheung KJ Jr; Li G. 2001. Tissue-specific regulation of Chk1 expression by p53. Exp Mol Pathol 71(2):156-60. PubMed: 11599922MGI: J:106234
- Chin MY; Li G. 2003. Tissue-specific regulation of checkpoint kinase 2 expression by p53. Exp Mol Pathol 75(2):131-6. PubMed: 14516774MGI: J:105841
- Christophorou MA; Martin-Zanca D; Soucek L; Lawlor ER; Brown-Swigart L; Verschuren EW; Evan GI. 2005. Temporal dissection of p53 function in vitro and in vivo. Nat Genet 37(7):718-26. PubMed: 15924142MGI: J:99305
- Coles AH; Liang H; Zhu Z; Marfella CG; Kang J; Imbalzano AN; Jones SN. 2007. Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis. Cancer Res 67(5):2054-61. PubMed: 17332334MGI: J:118602
- Coles AH; Marfella CG; Imbalzano AN; Steinman HA; Garlick DS; Gerstein RM; Jones SN. 2008. p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis. Cancer Res 68(21):8705-14. PubMed: 18974112MGI: J:140640
- Colombel M; Radvanyi F; Blanche M; Abbou C; Buttyan R; Donehower LA; Chopin D; Thiery JP. 1995. Androgen suppressed apoptosis is modified in p53 deficient mice. Oncogene 10(7):1269-74. PubMed: 7731676MGI: J:24547
- Condorelli GL; Facchiano F; Valtieri M; Proietti E; Vitelli L; Lulli V; Huebner K; Peschle C; Croce CM. 1996. T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice. Cancer Res 56(22):5113-9. PubMed: 8912842MGI: J:101583
- Conley ZR; Hague M; Kurosaka H; Dixon J; Dixon MJ; Trainor PA. 2016. A quantitative method for defining high-arched palate using the Tcof1(+/-) mutant mouse as a model. Dev Biol 415(2):296-305. PubMed: 26772999MGI: J:233608
- Cormier RT; Dove WF. 2000. Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res 60(14):3965-70. PubMed: 10919675MGI: J:63662
- Cowley DO; Muse GW; Van Dyke T. 2005. A dominant interfering Bub1 mutant is insufficient to induce or alter thymic tumorigenesis in vivo, even in a sensitized genetic background. Mol Cell Biol 25(17):7796-802. PubMed: 16107724MGI: J:100551
- Cui W; Kemp CJ; Duffie E; Balmain A; Akhurst RJ. 1994. Lack of transforming growth factor-beta 1 expression in benign skin tumors of p53null mice is prognostic for a high risk of malignant conversion. Cancer Res 54(22):5831-6. PubMed: 7954410MGI: J:21368
- D'Sa-Eipper C; Leonard JR; Putcha G; Zheng TS; Flavell RA; Rakic P; Kuida K; Roth KA. 2001. DNA damage-induced neural precursor cell apoptosis requires p53 and caspase 9 but neither Bax nor caspase 3. Development 128(1):137-46. PubMed: 11092819MGI: J:115386
- Dai C; Celestino JC; Okada Y; Louis DN; Fuller GN; Holland EC. 2001. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes Dev 15(15):1913-25. PubMed: 11485986MGI: J:77287
- Damo LA; Snyder PW; Franklin DS. 2005. Tumorigenesis in p27/p53- and p18/p53-double null mice: Functional collaboration between the pRb and p53 pathways. Mol Carcinog 42(2):109-20. PubMed: 15584024MGI: J:95497
- Darini CY; Pisani DF; Hofman P; Pedeutour F; Sudaka I; Chomienne C; Dani C; Ladoux A. 2012. Self-renewal gene tracking to identify tumour-initiating cells associated with metastatic potential. Oncogene 31(19):2438-49. PubMed: 21927026MGI: J:186139
- Dass SB; Bucci TJ; Heflich RH; Casciano DA. 1999. Evaluation of the transgenic p53+/- mouse for detecting genotoxic liver carcinogens in a short-term bioassay. Cancer Lett 143(1):81-5. PubMed: 10465341MGI: J:57142
- Davies AM; Rosenthal A. 1994. Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins. Neurosci Lett 182(1):112-4. PubMed: 7891874MGI: J:25003
- Deeb KK; Michalowska AM; Yoon CY; Krummey SM; Hoenerhoff MJ; Kavanaugh C; Li MC; Demayo FJ; Linnoila I; Deng CX; Lee EY; Medina D; Shih JH; Green JE. 2007. Identification of an Integrated SV40 T/t-Antigen Cancer Signature in Aggressive Human Breast, Prostate, and Lung Carcinomas with Poor Prognosis. Cancer Res 67(17):8065-8080. PubMed: 17804718MGI: J:124885
- Demidov ON; Timofeev O; Lwin HN; Kek C; Appella E; Bulavin DV. 2007. Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine. Cell Stem Cell 1(2):180-90. PubMed: 18371349MGI: J:139068
- Demidov ON; Zhu Y; Kek C; Goloudina AR; Motoyama N; Bulavin DV. 2012. Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis. Cell Death Differ 19(11):1761-8. PubMed: 22555459MGI: J:204789
- Dierks C; Grbic J; Zirlik K; Beigi R; Englund NP; Guo GR; Veelken H; Engelhardt M; Mertelsmann R; Kelleher JF; Schultz P; Warmuth M. 2007. Essential role of stromally induced hedgehog signaling in B-cell malignancies. Nat Med 13(8):944-51. PubMed: 17632527MGI: J:126550
- Difilippantonio MJ; Petersen S; Chen HT; Johnson R; Jasin M; Kanaar R; Ried T; Nussenzweig A. 2002. Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification. J Exp Med 196(4):469-80. PubMed: 12186839MGI: J:78496
- Difilippantonio MJ; Zhu J; Chen HT; Meffre E; Nussenzweig MC; Max EE; Ried T; Nussenzweig A. 2000. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature 404(6777):510-4. PubMed: 10761921MGI: J:72312
- Donehower LA; Godley LA; Aldaz CM; Pyle R; Shi YP; Pinkel D; Gray J; Bradley A; Medina D; Varmus HE. 1995. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev 9(7):882-95. PubMed: 7705663MGI: J:24407
- Donehower LA; Harvey M; Slagle BL; McArthur MJ; Montgomery CA Jr; Butel JS; Bradley A. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356(6366):215-21. PubMed: 1552940MGI: J:1999
- Donehower LA; Harvey M; Vogel H; McArthur MJ; Montgomery CA Jr; Park SH; Thompson T; Ford RJ; Bradley A. 1995. Effects of genetic background on tumorigenesis in p53-deficient mice. Mol Carcinog 14(1):16-22. PubMed: 7546219MGI: J:29486
- Dong W; Arpin C; Accardi R; Gissmann L; Sylla BS; Marvel J; Tommasino M. 2008. Loss of p53 or p73 in human papillomavirus type 38 E6 and E7 transgenic mice partially restores the UV-activated cell cycle checkpoints. Oncogene 27(20):2923-8. PubMed: 18026133MGI: J:135503
- Duan W; Gao L; Jin D; Otterson GA; Villalona-Calero MA. 2008. Lung specific expression of a human mutant p53 affects cell proliferation in transgenic mice. Transgenic Res 17(3):355-66. PubMed: 17968669MGI: J:135366
- Dube N; Bourdeau A; Heinonen KM; Cheng A; Loy AL; Tremblay ML. 2005. Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. Cancer Res 65(21):10088-95. PubMed: 16267035MGI: J:102693
- Dumble M; Moore L; Chambers SM; Geiger H; Van Zant G; Goodell MA; Donehower LA. 2007. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood 109(4):1736-42. PubMed: 17032926MGI: J:131480
- Dunn SE; Kari FW; French J; Leininger JR; Travlos G; Wilson R ; Barrett JC. 1997. Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res 57(21):4667-72. PubMed: 9354418MGI: J:43765
- Eastin WC; Haseman JK; Mahler JF; Bucher JR. 1998. The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens. Toxicol Pathol 26(4):461-73. PubMed: 9715504MGI: J:217057
- Edagawa M; Kawauchi J; Hirata M; Goshima H; Inoue M; Okamoto T; Murakami A; Maehara Y; Kitajima S. 2014. Role of activating transcription factor 3 (ATF3) in endoplasmic reticulum (ER) stress-induced sensitization of p53-deficient human colon cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis through up-regulation of death receptor 5 (DR5) by zerumbone and celecoxib. J Biol Chem 289(31):21544-61. PubMed: 24939851MGI: J:219618
- Eissmann M; Melzer IM; Fernandez SB; Michel G; Hrabe de Angelis M; Hoefler G; Finkenwirth P; Jauch A; Schoell B; Grez M; Schmidt M; Bartholomae CC; Newrzela S; Haetscher N; Rieger MA; Zachskorn C; Mittelbronn M; Zornig M. 2013. Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms. Oncogene 32(20):2586-91. PubMed: 22751129MGI: J:198019
- El Ghamrasni S; Pamidi A; Halaby MJ; Bohgaki M; Cardoso R; Li L; Venkatesan S; Sethu S; Hirao A; Mak TW; Hande MP; Hakem A; Hakem R. 2011. Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer. PLoS Genet 7(5):e1001385. PubMed: 21625617MGI: J:172721
- Fabris VT. 2014. From chromosomal abnormalities to the identification of target genes in mouse models of breast cancer. Cancer Genet 207(6):233-46. PubMed: 25176624MGI: J:214799
- Fang M; Simeonova I; Bardot B; Lejour V; Jaber S; Bouarich-Bourimi R; Morin A; Toledo F. 2014. Mdm4 loss in mice expressing a p53 hypomorph alters tumor spectrum without improving survival. Oncogene 33(10):1336-9. PubMed: 23474762MGI: J:212378
- Fein M; Peters JH; Baril N; McGarvey M; Chandrasoma P; Shibata D ; Laird PW ; Skinner KA. 1999. Loss of function of Trp53, but not Apc, leads to the development of esophageal adenocarcinoma in mice with jejunoesophageal reflux. J Surg Res 83(1):48-55. PubMed: 10210642MGI: J:55225
- Ferguson DO; Sekiguchi JM; Chang S; Frank KM; Gao Y; DePinho RA; Alt FW. 2000. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci U S A 97(12):6630-3. PubMed: 10823907MGI: J:62721
- Finch A; Prescott J; Shchors K; Hunt A; Soucek L; Dansen TB; Swigart LB; Evan GI. 2006. Bcl-xL gain of function and p19 ARF loss of function cooperate oncogenically with Myc in vivo by distinct mechanisms. Cancer Cell 10(2):113-20. PubMed: 16904610MGI: J:112704
- Finch GL; March TH; Hahn FF; Barr EB; Belinsky SA; Hoover MD; Lechner JF; Nikula KJ; Hobbs CH. 1998. Carcinogenic responses of transgenic heterozygous p53 knockout mice to inhaled 239PuO2 or metallic beryllium. Toxicol Pathol 26(4):484-91. PubMed: 9715507MGI: J:101542
- Finch RA; Donoviel DB; Potter D; Shi M; Fan A; Freed DD; Wang CY; Zambrowicz BP; Ramirez-Solis R; Sands AT; Zhang N. 2002. mdmx is a negative regulator of p53 activity in vivo. Cancer Res 62(11):3221-5. PubMed: 12036937MGI: J:77030
- Finnberg N; Stenius U; Hogberg J. 2004. Heterozygous p53-deficient (+/-) mice develop fewer p53-negative preneoplastic focal liver lesions in response to treatment with diethylnitrosamine than do wild-type (+/+) mice. Cancer Lett 207(2):149-55. PubMed: 15072823MGI: J:89140
- Ford NA; Dunlap SM; Wheatley KE; Hursting SD. 2013. Obesity, independent of p53 gene dosage, promotes mammary tumor progression and upregulates the p53 regulator microRNA-504. PLoS One 8(6):e68089. PubMed: 23840816MGI: J:204324
- Foster KW; Liu Z; Nail CD; Li X; Fitzgerald TJ; Bailey SK; Frost AR; Louro ID; Townes TM; Paterson AJ; Kudlow JE; Lobo-Ruppert SM; Ruppert JM. 2005. Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene 24(9):1491-500. PubMed: 15674344MGI: J:96886
- Fox JG; Li X; Cahill RJ; Andrutis K; Rustgi AK; Odze R; Wang TC. 1996. Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice. Gastroenterology 110(1):155-66. PubMed: 8536852MGI: J:31369
- Franco S; Murphy MM; Li G; Borjeson T; Boboila C; Alt FW. 2008. DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med 205(3):557-64. PubMed: 18316419MGI: J:133132
- Frank KM; Sharpless NE; Gao Y; Sekiguchi JM; Ferguson DO; Zhu C; Manis JP; Horner J; DePinho RA; Alt FW. 2000. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell 5(6):993-1002. PubMed: 10911993MGI: J:63078
- Frappart PO; Tong WM; Demuth I; Radovanovic I; Herceg Z; Aguzzi A; Digweed M; Wang ZQ. 2005. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med 11(6):538-44. PubMed: 15821748MGI: J:98316
- French JE. 2004. Identification and characterization of potential human carcinogens using B6.129tmlTrp53 heterozygous null mice and loss of heterozygosity at the Trp53 locus IARC Sci Publ (157):271-87. PubMed: 15055301MGI: J:90351
- French JE; Lacks GD; Trempus C; Dunnick JK; Foley J; Mahler J; Tice RR; Tennant RW. 2001. Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent. (Errata: Vol. 23(2):373) Carcinogenesis 22(1):99-106. PubMed: 11159747MGI: J:67080
- Frum RA; Singh S; Vaughan C; Mukhopadhyay ND; Grossman SR; Windle B; Deb S; Deb SP. 2014. The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing. Nucleic Acids Res 42(2):926-40. PubMed: 24163099MGI: J:211903
- Fukasawa K; Wiener F; Vande Woude GF; Mai S. 1997. Genomic instability and apoptosis are frequent in p53 deficient young mice. Oncogene 15(11):1295-302. PubMed: 9315097MGI: J:43057
- Funabashi H; Uchida K; Kado S; Matsuoka Y; Ohwaki M. 2001. Establishment of a Tcrb and Trp53 genes deficient mouse strain as an animal model for spontaneous colorectal cancer. Exp Anim 50(1):41-7. PubMed: 11326422MGI: J:68090
- Gaidarenko O; Xu Y. 2009. Transcription activity is required for p53-dependent tumor suppression. Oncogene 28(49):4397-401. PubMed: 19767771MGI: J:157041
- Gao J; Huang HY; Pak J; Cheng J; Zhang ZT; Shapiro E; Pellicer A; Sun TT; Wu XR. 2004. p53 deficiency provokes urothelial proliferation and synergizes with activated Ha-ras in promoting urothelial tumorigenesis. Oncogene 23(3):687-96. PubMed: 14737103MGI: J:88102
- Gate L; Majumdar RS; Lunk A; Tew KD. 2005. Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice. Int J Cancer 113(1):29-35. PubMed: 15386426MGI: J:94440
- Gatza CE; Dumble M; Kittrell F; Edwards DG; Dearth RK; Lee AV; Xu J; Medina D; Donehower LA. 2008. Altered mammary gland development in the p53+/m mouse, a model of accelerated aging. Dev Biol 313(1):130-41. PubMed: 17996864MGI: J:130123
- Geng Y; Walls KC; Ghosh AP; Akhtar RS; Klocke BJ; Roth KA. 2010. Cytoplasmic p53 and activated Bax regulate p53-dependent, transcription-independent neural precursor cell apoptosis. J Histochem Cytochem 58(3):265-75. PubMed: 19901272MGI: J:160504
- Ghebranious N; Sell S. 1998. Hepatitis B injury, male gender, aflatoxin, and p53 expression each contribute to hepatocarcinogenesis in transgenic mice. Hepatology 27(2):383-91. PubMed: 9462635MGI: J:47062
- Ghebranious N; Sell S. 1998. The mouse equivalent of the human p53ser249 mutation p53ser246 enhances aflatoxin hepatocarcinogenesis in hepatitis B surface antigen transgenic and p53 heterozygous null mice. Hepatology 27(4):967-73. PubMed: 9537435MGI: J:47088
- Giuriato S; Ryeom S; Fan AC; Bachireddy P; Lynch RC; Rioth MJ; van Riggelen J; Kopelman AM; Passegue E; Tang F; Folkman J; Felsher DW. 2006. Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Proc Natl Acad Sci U S A 103(44):16266-71. PubMed: 17056717MGI: J:115637
- Gladdy RA; Taylor MD; Williams CJ; Grandal I; Karaskova J; Squire JA; Rutka JT; Guidos CJ; Danska JS. 2003. The RAG-1/2 endonuclease causes genomic instability and controls CNS complications of lymphoblastic leukemia in p53/Prkdc-deficient mice. Cancer Cell 3(1):37-50. PubMed: 12559174MGI: J:81538
- Gostissa M; Yan CT; Bianco JM; Cogne M; Pinaud E; Alt FW. 2009. Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region. Nature 462(7274):803-7. PubMed: 20010689MGI: J:155801
- Gould S; Sidaway J; Sansom N; Betton G; Orton T. 2001. Phenobarbitone - induced liver response in wild type and in p53 deficient mice. Toxicol Lett 122(2):131-40. PubMed: 11439219MGI: J:70628
- Green MR; Monti S; Dalla-Favera R; Pasqualucci L; Walsh NC; Schmidt-Supprian M; Kutok JL; Rodig SJ; Neuberg DS; Rajewsky K; Golub TR; Alt FW; Shipp MA; Manis JP. 2011. Signatures of murine B-cell development implicate Yy1 as a regulator of the germinal center-specific program. Proc Natl Acad Sci U S A 108(7):2873-8. PubMed: 21282644MGI: J:169063
- Greenhalgh DA; Wang XJ; Donehower LA; Roop DR. 1996. Paradoxical tumor inhibitory effect of p53 loss in transgenic mice expressing epidermal-targeted v-rasHa, v-fos, or human transforming growth factor alpha. Cancer Res 56(19):4413-23. PubMed: 8813135MGI: J:101585
- Griesmann H; Schlereth K; Krause M; Samans B; Stiewe T. 2009. p53 and p73 in suppression of Myc-driven lymphomagenesis. Int J Cancer 124(2):502-6. PubMed: 18942718MGI: J:145779
- Grisendi S; Bernardi R; Rossi M; Cheng K; Khandker L; Manova K; Pandolfi PP. 2005. Role of nucleophosmin in embryonic development and tumorigenesis. Nature 437(7055):147-53. PubMed: 16007073MGI: J:101494
- Grossman D; Kim PJ; Blanc-Brude OP; Brash DE; Tognin S; Marchisio PC; Altieri DC. 2001. Transgenic expression of survivin in keratinocytes counteracts UVB-induced apoptosis and cooperates with loss of p53. J Clin Invest 108(7):991-9. PubMed: 11581300MGI: J:93483
- Gu P; Deng W; Lei M; Chang S. 2013. Single strand DNA binding proteins 1 and 2 protect newly replicated telomeres. Cell Res 23(5):705-19. PubMed: 23459151MGI: J:228558
- Guarnerio J; Riccardi L; Taulli R; Maeda T; Wang G; Hobbs RM; Song MS; Sportoletti P; Bernardi R; Bronson RT; Castillo-Martin M; Cordon-Cardo C; Lunardi A; Pandolfi PP. 2015. A genetic platform to model sarcomagenesis from primary adult mesenchymal stem cells. Cancer Discov 5(4):396-409. PubMed: 25614485MGI: J:224246
- Guerra C; Schuhmacher AJ; Canamero M; Grippo PJ; Verdaguer L; Perez-Gallego L; Dubus P; Sandgren EP; Barbacid M. 2007. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell 11(3):291-302. PubMed: 17349585MGI: J:119988
- Guidos CJ; Williams CJ; Grandal I; Knowles G; Huang MT; Danska JS. 1996. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev 10(16):2038-54. PubMed: 8769647MGI: J:102044
- Guijarro MV; Dahiya S; Danielson LS; Segura MF; Vales-Lara FM; Menendez S; Popiolek D; Mittal K; Wei JJ; Zavadil J; Cordon-Cardo C; Pandolfi PP; Hernando E. 2013. Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling. Am J Pathol 182(6):2015-27. PubMed: 23708211MGI: J:199111
- Guikema JE; Gerstein RM; Linehan EK; Cloherty EK; Evan-Browning E; Tsuchimoto D; Nakabeppu Y; Schrader CE. 2011. Apurinic/Apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge. J Immunol 186(4):1943-50. PubMed: 21228350MGI: J:169165
- Guikema JE; Schrader CE; Brodsky MH; Linehan EK; Richards A; El Falaky N; Li DH; Sluss HK; Szomolanyi-Tsuda E; Stavnezer J. 2010. p53 represses class switch recombination to IgG2a through its antioxidant function. J Immunol 184(11):6177-87. PubMed: 20483782MGI: J:161216
- Guimond MJ; Wang B; Fujita J; Terhorst C; Croy BA. 1996. Pregnancy-associated uterine granulated metrial gland cells in mutant and transgenic mice. Am J Reprod Immunol 35(6):501-9. PubMed: 8792932MGI: J:113082
- Guo SL; Ye H; Teng Y; Wang YL; Yang G; Li XB; Zhang C; Yang X; Yang ZZ; Yang X. 2013. Akt-p53-miR-365-cyclin D1/cdc25A axis contributes to gastric tumorigenesis induced by PTEN deficiency. Nat Commun 4:2544. PubMed: 24149576MGI: J:206196
- Gupta A; Guerin-Peyrou TG; Sharma GG; Park C; Agarwal M; Ganju RK; Pandita S; Choi K; Sukumar S; Pandita RK; Ludwig T; Pandita TK. 2008. The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis. Mol Cell Biol 28(1):397-409. PubMed: 17967868MGI: J:128936
- Gurley KE; Vo K; Kemp CJ. 1998. DNA double-strand breaks, p53, and apoptosis during lymphomagenesis in scid/scid mice. Cancer Res 58(14):3111-5. PubMed: 9679979MGI: J:49372
- Ha L; Ichikawa T; Anver M; Dickins R; Lowe S; Sharpless NE; Krimpenfort P; Depinho RA; Bennett DC; Sviderskaya EV; Merlino G. 2007. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proc Natl Acad Sci U S A 104(26):10968-73. PubMed: 17576930MGI: J:122592
- Haapajarvi T; Kivinen L; Heiskanen A; des Bordes C; Datto MB; Wang XF; Laiho M. 1999. UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner. Exp Cell Res 248(1):272-9. PubMed: 10094833MGI: J:115222
- Haks MC; Krimpenfort P; van den Brakel JH; Kruisbeek AM. 1999. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity 11(1):91-101. PubMed: 10435582MGI: J:110456
- Halaby MJ; Hakem A; Li L; El Ghamrasni S; Venkatesan S; Hande PM; Sanchez O; Hakem R. 2013. Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis. PLoS Genet 9(1):e1003259. PubMed: 23382699MGI: J:195154
- Halberg RB; Chen X; Amos-Landgraf JM; White A; Rasmussen K; Clipson L; Pasch C; Sullivan R; Pitot HC; Dove WF. 2008. The pleiotropic phenotype of apc mutations in the mouse: allele specificity and effects of the genetic background. Genetics 180(1):601-9. PubMed: 18723878MGI: J:139675
- Halberg RB; Katzung DS; Hoff PD; Moser AR; Cole CE; Lubet RA; Donehower LA; Jacoby RF; Dove WF. 2000. Tumorigenesis in the multiple intestinal neoplasia mouse: redundancy of negative regulators and specificity of modifiers. Proc Natl Acad Sci U S A 97(7):3461-6. PubMed: 10716720MGI: J:61200
- Hallenborg P; Fjaere E; Liaset B; Petersen RK; Murano I; Sonne SB; Falkerslev M; Winther S; Jensen BA; Ma T; Hansen JB; Cinti S; Blagoev B; Madsen L; Kristiansen K. 2016. p53 regulates expression of uncoupling protein 1 through binding and repression of PPARgamma coactivator-1alpha. Am J Physiol Endocrinol Metab 310(2):E116-28. PubMed: 26578713MGI: J:235907
- Harris MA; Yang H; Low BE; Mukherje J; Guha A; Bronson RT; Shultz LD; Israel MA; Yun K. 2008. Cancer stem cells are enriched in the side population cells in a mouse model of glioma. Cancer Res 68(24):10051-9. PubMed: 19074870MGI: J:142242
- Hartman TR; Liu D; Zilfou JT; Robb V; Morrison T; Watnick T; Henske EP. 2009. The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway. Hum Mol Genet 18(1):151-63. PubMed: 18845692MGI: J:143404
- Harvey M; McArthur MJ; Montgomery CA Jr; Bradley A; Donehower LA. 1993. Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J 7(10):938-43. PubMed: 8344491MGI: J:59272
- Harvey M; McArthur MJ; Montgomery CA Jr; Butel JS; Bradley A; Donehower LA. 1993. Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice [see comments] Nat Genet 5(3):225-9. PubMed: 8275085MGI: J:15423
- Harvey M; Sands AT; Weiss RS; Hegi ME; Wiseman RW; Pantazis P; Giovanella BC; Tainsky MA; Bradley A; Donehower LA. 1993. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8(9):2457-67. PubMed: 8103211MGI: J:14162
- Harvey M; Vogel H; Lee EY; Bradley A; Donehower LA. 1995. Mice deficient in both p53 and Rb develop tumors primarily of endocrine origin. Cancer Res 55(5):1146-51. PubMed: 7867001MGI: J:23284
- Harvey M; Vogel H; Morris D; Bradley A; Bernstein A; Donehower LA. 1995. A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice. Nat Genet 9(3):305-11. PubMed: 7773294MGI: J:23262
- Hasham MG; Donghia NM; Coffey E; Maynard J; Snow KJ; Ames J; Wilpan RY; He Y; King BL; Mills KD. 2010. Widespread genomic breaks generated by activation-induced cytidine deaminase are prevented by homologous recombination. Nat Immunol 11(9):820-6. PubMed: 20657597MGI: J:163929
- Hasham MG; Snow KJ; Donghia NM; Branca JA; Lessard MD; Stavnezer J; Shopland LS; Mills KD. 2012. Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase. J Immunol 189(5):2374-82. PubMed: 22826323MGI: J:189871
- Healy LN; Pluta LJ; James RA; Janszen DB; Torous D; French JE; Recio L. 2001. Induction and time-dependent accumulation of micronuclei in peripheral blood of transgenic p53+/- mice, Tg.AC (v-Ha-ras) and parental wild-type (C57BL/6 and FVB/N) mice exposed to benzene by inhalation. Mutagenesis 16(2):163-8. PubMed: 11230560MGI: J:134552
- Hendley AM; Wang YJ; Polireddy K; Alsina J; Ahmed I; Lafaro KJ; Zhang H; Roy N; Savidge SG; Cao Y; Hebrok M; Maitra A; Reynolds AB; Goggins M; Younes M; Iacobuzio-Donahue CA; Leach SD; Bailey JM. 2016. p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia. Cancer Res 76(11):3351-63. PubMed: 27032419MGI: J:231905
- Hendry JH; Broadbent DA; Roberts SA; Potten CS. 2000. Effects of deficiency in p53 or bcl-2 on the sensitivity of clonogenic cells in the small intestine to low dose-rate irradiation Int J Radiat Biol 76(4):559-65. PubMed: 10815637MGI: J:62429
- Heo KS; Lee H; Nigro P; Thomas T; Le NT; Chang E; McClain C; Reinhart-King CA; King MR; Berk BC; Fujiwara K; Woo CH; Abe J. 2011. PKC{zeta} mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. J Cell Biol 193(5):867-84. PubMed: 21624955MGI: J:172726
- Hernandez-Porras I; Schuhmacher AJ; Garcia-Medina R; Jimenez B; Canamero M; de Martino A; Guerra C. 2016. K-Ras(V14I) -induced Noonan syndrome predisposes to tumour development in mice. J Pathol 239(2):206-17. PubMed: 27174785MGI: J:241552
- Herranz D; Serrano M. 2010. SIRT1: recent lessons from mouse models. Nat Rev Cancer 10(12):819-23. PubMed: 21102633MGI: J:166994
- Herschkowitz JI; Simin K; Weigman VJ; Mikaelian I; Usary J; Hu Z; Rasmussen KE; Jones LP; Assefnia S; Chandrasekharan S; Backlund MG; Yin Y; Khramtsov AI; Bastein R; Quackenbush J; Glazer RI; Brown PH; Green JE; Kopelovich L; Furth PA; Palazzo JP; Olopade OI; Bernard PS; Churchill GA; Van Dyke T; Perou CM. 2007. Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol 8(5):R76. PubMed: 17493263MGI: J:160877
- Hertwig F; Meyer K; Braun S; Ek S; Spang R; Pfenninger CV; Artner I; Prost G; Chen X; Biegel JA; Judkins AR; Englund E; Nuber UA. 2012. Definition of genetic events directing the development of distinct types of brain tumors from postnatal neural stem/progenitor cells. Cancer Res 72(13):3381-92. PubMed: 22719073MGI: J:191033
- Hesselager G; Uhrbom L; Westermark B; Nister M. 2003. Complementary effects of platelet-derived growth factor autocrine stimulation and p53 or Ink4a-Arf deletion in a mouse glioma model. Cancer Res 63(15):4305-9. PubMed: 12907595MGI: J:84848
- Hettmann T; Barton K; Leiden JM. 2000. Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol 222(1):110-23. PubMed: 10885750MGI: J:62578
- Hill KA; Buettner VL; Heidt A; Chen LL; Li W; Gonzalez KD; Wang JC; Scaringe WA; Sommer SS. 2006. Most spontaneous tumors in a mouse model of Li-Fraumeni syndrome do not have a mutator phenotype. Carcinogenesis 27(9):1860-6. PubMed: 16597646MGI: J:113346
- Hirao A; Cheung A; Duncan G; Girard PM; Elia AJ; Wakeham A; Okada H; Sarkissian T; Wong JA; Sakai T; De Stanchina E; Bristow RG; Suda T; Lowe SW; Jeggo PA; Elledge SJ; Mak TW. 2002. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol 22(18):6521-32. PubMed: 12192050MGI: J:78491
- Hirata A; Tsukamoto T; Yamamoto M; Sakai H; Yanai T; Masegi T; Donehower LA; Tatematsu M. 2006. Organ-specific susceptibility of p53 knockout mice to N-bis(2-hydroxypropyl)nitrosamine carcinogenesis. Cancer Lett 238(2):271-83. PubMed: 16150539MGI: J:110174
- Holcomb VB; Vogel H; Marple T; Kornegay RW; Hasty P. 2006. Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. Oncogene 25(54):7159-65. PubMed: 16751807MGI: J:141515
- Holland EC; Hively WP; DePinho RA; Varmus HE. 1998. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev 12(23):3675-85. PubMed: 9851974MGI: J:52161
- Hollander MC; Patterson AD; Salvador JM; Anver MR; Hunger SP; Fornace AJ. 2005. Gadd45a acts as a modifier locus for lymphoblastic lymphoma. Leukemia 19(5):847-50. PubMed: 15744335MGI: J:97896
- Hollander MC; Sheikh MS; Bulavin DV; Lundgren K; Augeri-Henmueller L; Shehee R; Molinaro TA; Kim KE; Tolosa E; Ashwell JD; Rosenberg MP; Zhan Q; Fernandez-Salguero PM; Morgan WF; Deng CX; Fornace AJ Jr. 1999. Genomic instability in Gadd45a-deficient mice. Nat Genet 23(2):176-84. PubMed: 10508513MGI: J:57882
- Hollern DP; Andrechek ER. 2014. A genomic analysis of mouse models of breast cancer reveals molecular features of mouse models and relationships to human breast cancer Breast Cancer Res 16:R59. MGI: J:210803
- Houghtaling S; Granville L; Akkari Y; Torimaru Y; Olson S; Finegold M; Grompe M. 2005. Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice. Cancer Res 65(1):85-91. PubMed: 15665282MGI: J:95530
- Howes KA; Ransom N; Papermaster DS; Lasudry JG; Albert DM; Windle JJ. 1994. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes Dev 8(11):1300-10. PubMed: 7986270MGI: J:78203
- Huang HS; Chu SC; Hsu CF; Chen PC; Ding DC; Chang MY; Chu TY. 2015. Mutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis. Carcinogenesis 36(11):1419-28. PubMed: 26363031MGI: J:226629
- Huang S; Li Y; Chen Y; Podsypanina K; Chamorro M; Olshen AB; Desai KV; Tann A; Petersen D; Green JE; Varmus HE. 2005. Changes in gene expression during the development of mammary tumors in MMTV-Wnt-1 transgenic mice. Genome Biol 6(10):R84. PubMed: 16207355MGI: J:103821
- Hueber AO; Bosser S; Zornig M. 2004. Transgenic overexpression of a dominant negative mutant of FADD that, although counterselected during tumor progression, cooperates in L-myc-induced tumorigenesis. Int J Cancer 112(3):536. PubMed: 15382083MGI: J:92535
- Hulla JE; French JE; Dunnick JK. 2001. Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice. Carcinogenesis 22(1):89-98. PubMed: 11159746MGI: J:67081
- Hundley JE; Koester SK; Troyer DA; Hilsenbeck SG; Subler MA; Windle JJ. 1997. Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53. Mol Cell Biol 17(2):723-31. PubMed: 9001226MGI: J:37670
- Hursting SD; Lavigne JA; Berrigan D; Donehower LA; Davis BJ; Phang JM; Barrett JC; Perkins SN. 2004. Diet-Gene Interactions in p53-Deficient Mice: Insulin-like Growth Factor-1 as a Mechanistic Target. J Nutr 134(9):2482S-6S. PubMed: 15333746MGI: J:92891
- Hursting SD; Perkins SN; Haines DC; Ward JM; Phang JM. 1995. Chemoprevention of spontaneous tumorigenesis in p53-knockout mice. Cancer Res 55(18):3949-53. PubMed: 7664260MGI: J:91181
- Hursting SD; Perkins SN; Phang JM. 1994. Calorie restriction delays spontaneous tumorigenesis in p53-knockout transgenic mice. Proc Natl Acad Sci U S A 91(15):7036-40. PubMed: 8041741MGI: J:97286
- Huse JT; Holland EC. 2009. Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol 19(1):132-43. PubMed: 19076778MGI: J:173443
- Hussain SP; He P; Subleski J; Hofseth LJ; Trivers GE; Mechanic L; Hofseth AB; Bernard M; Schwank J; Nguyen G; Mathe E; Djurickovic D; Haines D; Weiss J; Back T; Gruys E; Laubach VE; Wiltrout RH; Harris CC. 2008. Nitric oxide is a key component in inflammation-accelerated tumorigenesis. Cancer Res 68(17):7130-6. PubMed: 18757428MGI: J:138926
- Hussain SP; Trivers GE; Hofseth LJ; He P; Shaikh I; Mechanic LE; Doja S; Jiang W; Subleski J; Shorts L; Haines D; Laubach VE; Wiltrout RH; Djurickovic D; Harris CC. 2004. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res 64(19):6849-53. PubMed: 15466171MGI: J:93662
- Iatropoulos MJ; Jeffrey AM; Schluter G; Enzmann HG; Williams GM. 2001. Bioassay of mannitol and caprolactam and assessment of response to diethylnitrosamine in heterozygous p53-deficient (+/-) and wild type (+/+) mice. Arch Toxicol 75(1):52-8. PubMed: 11357521MGI: J:69197
- Ibrahim MM; Razmara M; Nguyen D; Donahue RJ; Wubah JA; Knudsen TB. 1998. Altered expression of mitochondrial 16S ribosomal RNA in p53-deficient mouse embryos revealed by differential display. Biochim Biophys Acta 1403(3):254-64. PubMed: 9685670MGI: J:49482
- Ihrie RA; Bronson RT; Attardi LD. 2006. Adult mice lacking the p53/p63 target gene Perp are not predisposed to spontaneous tumorigenesis but display features of ectodermal dysplasia syndromes. Cell Death Differ 13(9):1614-8. PubMed: 16485031MGI: J:126293
- Iidaka T; Tsukamoto T; Totsuka Y; Hirata A; Sakai H; Shirai N; Yamamoto M; Wakabayashi K; Yanai T; Masegi T; Donehower LA; Tatematsu M. 2005. Lack of elevated liver carcinogenicity of aminophenylnorharman in p53-deficient mice. Cancer Lett 217(2):149-59. PubMed: 15617832MGI: J:95218
- Inomata K; Aoto T; Binh NT; Okamoto N; Tanimura S; Wakayama T; Iseki S; Hara E; Masunaga T; Shimizu H; Nishimura EK. 2009. Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation. Cell 137(6):1088-99. PubMed: 19524511MGI: J:157347
- Iozzo RV; Chakrani F; Perrotti D; McQuillan DJ; Skorski T; Calabretta B; Eichstetter I. 1999. Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis. Proc Natl Acad Sci U S A 96(6):3092-7. PubMed: 10077642MGI: J:53511
- Ishimaru N; Arakaki R; Omotehara F; Yamada K; Mishima K; Saito I; Hayashi Y. 2006. Novel role for RbAp48 in tissue-specific, estrogen deficiency-dependent apoptosis in the exocrine glands. Mol Cell Biol 26(8):2924-35. PubMed: 16581768MGI: J:107385
- Israelsen WJ; Dayton TL; Davidson SM; Fiske BP; Hosios AM; Bellinger G; Li J; Yu Y; Sasaki M; Horner JW; Burga LN; Xie J; Jurczak MJ; DePinho RA; Clish CB; Jacks T; Kibbey RG; Wulf GM; Di Vizio D; Mills GB; Cantley LC; Vander Heiden MG. 2013. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell 155(2):397-409. PubMed: 24120138MGI: J:205213
- Ito D; Kamijo R; Nakanishi Y; Toyoshima T; Takizawa K; Sumitani K; Nagumo M. 1999. Altered growth response of oral mucosal keratinocytes in p53-deficient mice. J Oral Pathol Med 28(8):371-6. PubMed: 10478963MGI: J:59498
- Jack MT; Woo RA; Hirao A; Cheung A; Mak TW; Lee PW. 2002. Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response. Proc Natl Acad Sci U S A 99(15):9825-9. PubMed: 12097646MGI: J:126186
- Jen KY; Song IY; Banta KL; Wu D; Mao JH; Balmain A. 2012. Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas. Blood 119(3):805-9. PubMed: 22117044MGI: J:181784
- Jenkins LM; Durell SR; Mazur SJ; Appella E. 2012. p53 N-terminal phosphorylation: a defining layer of complex regulation. Carcinogenesis 33(8):1441-9. PubMed: 22505655MGI: J:190776
- Jiang D; Dumur CI; Massey HD; Ramakrishnan V; Subler MA; Windle JJ. 2015. Comparison of effects of p53 null and gain-of-function mutations on salivary tumors in MMTV-Hras transgenic mice. PLoS One 10(2):e0118029. PubMed: 25695772MGI: J:226205
- Jiang D; Lenardo MJ; Zuniga-Pflucker JC. 1996. p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement. J Exp Med 183(4):1923-8. PubMed: 8666950MGI: J:110862
- Jiang W; Ananthaswamy HN; Muller HK; Kripke ML. 1999. p53 protects against skin cancer induction by UV-B radiation. Oncogene 18(29):4247-53. PubMed: 10435637MGI: J:124236
- Jiang W; Ananthaswamy HN; Muller HK; Ouhtit A; Bolshakov S; Ullrich SE; El-Naggar AK; Kripke ML. 2001. UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53. Proc Natl Acad Sci U S A 98(17):9790-5. PubMed: 11481437MGI: J:70914
- Johansson FK; Brodd J; Eklof C; Ferletta M; Hesselager G; Tiger CF; Uhrbom L; Westermark B. 2004. Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging. Proc Natl Acad Sci U S A 101(31):11334-7. PubMed: 15273287MGI: J:91806
- Johnsen AK; France J; Nagy N; Askew D; Abdul-Karim FW; Gerson SL; Sy MS; Harding CV. 2001. Systemic deficits in transporter for antigen presentation (TAP)-1 or proteasome subunit LMP2 have little or no effect on tumor incidence. Int J Cancer 91(3):366-72. PubMed: 11169961MGI: J:67509
- Johnson RM; Papp E; Grandal I; Kowalski PE; Nutter L; Wong RC; Joseph-George AM; Danska JS; Guidos CJ. 2014. MuLV-related endogenous retroviral elements and Flt3 participate in aberrant end-joining events that promote B-cell leukemogenesis. Genes Dev 28(11):1179-90. PubMed: 24888589MGI: J:211638
- Jones JM; Attardi L; Godley LA; Laucirica R; Medina D; Jacks T ; Varmus HE ; Donehower LA. 1997. Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis. Cell Growth Differ 8(8):829-38. PubMed: 9269892MGI: J:43335
- Jones LP; Tilli MT; Assefnia S; Torre K; Halama ED; Parrish A; Rosen EM; Furth PA. 2008. Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERalpha-negative and ERalpha-positive mammary preneoplasia and cancer. Oncogene 27(6):794-802. PubMed: 17653086MGI: J:132088
- Jones NC; Lynn ML; Gaudenz K; Sakai D; Aoto K; Rey JP; Glynn EF; Ellington L; Du C; Dixon J; Dixon MJ; Trainor PA. 2008. Prevention of the neurocristopathy Treacher Collins syndrome through inhibition of p53 function. Nat Med 14(2):125-33. PubMed: 18246078MGI: J:133682
- Jones SN; Hancock AR; Vogel H; Donehower LA; Bradley A. 1998. Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis. Proc Natl Acad Sci U S A 95(26):15608-12. PubMed: 9861017MGI: J:51661
- Jones SN; Roe AE; Donehower LA; Bradley A. 1995. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature 378(6553):206-8. PubMed: 7477327MGI: J:29811
- Jones SN; Sands AT; Hancock AR; Vogel H; Donehower LA; Linke SP; Wahl GM; Bradley A. 1996. The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2. Proc Natl Acad Sci U S A 93(24):14106-11. PubMed: 8943068MGI: J:37047
- Juvekar A; Burga LN; Hu H; Lunsford EP; Ibrahim YH; Balmana J; Rajendran A; Papa A; Spencer K; Lyssiotis CA; Nardella C; Pandolfi PP; Baselga J; Scully R; Asara JM; Cantley LC; Wulf GM. 2012. Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discov 2(11):1048-63. PubMed: 22915751MGI: J:193222
- Juvekar A; Hu H; Yadegarynia S; Lyssiotis CA; Ullas S; Lien EC; Bellinger G; Son J; Hok RC; Seth P; Daly MB; Kim B; Scully R; Asara JM; Cantley LC; Wulf GM. 2016. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proc Natl Acad Sci U S A 113(30):E4338-47. PubMed: 27402769MGI: J:235157
- Kado S; Uchida K; Funabashi H; Iwata S; Nagata Y; Ando M; Onoue M; Matsuoka Y; Ohwaki M; Morotomi M. 2001. Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice. Cancer Res 61(6):2395-8. PubMed: 11289103MGI: J:68471
- Kalamarides M; Niwa-Kawakita M; Leblois H; Abramowski V; Perricaudet M; Janin A; Thomas G; Gutmann DH; Giovannini M. 2002. Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse. Genes Dev 16(9):1060-5. PubMed: 12000789MGI: J:76478
- Kamimura K; Ohi H; Kubota T; Okazuka K; Yoshikai Y; Wakabayashi Y; Aoyagi Y; Mishima Y; Kominami R. 2007. Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development. Biochem Biophys Res Commun 355(2):538-42. PubMed: 17306224MGI: J:118644
- Kampa KM; Acoba JD; Chen D; Gay J; Lee H; Beemer K; Padiernos E; Boonmark N; Zhu Z; Fan AC; Bailey AS; Fleming WH; Corless C; Felsher DW; Naumovski L; Lopez CD. 2009. Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci U S A 106(11):4390-5. PubMed: 19251665MGI: J:146764
- Karlhofer FM; Orihuela MM; Yokoyama WM. 1995. Ly-49-independent natural killer (NK) cell specificity revealed by NK cell clones derived from p53-deficient mice. J Exp Med 181(5):1785-95. PubMed: 7722455MGI: J:24956
- Kelly-Spratt KS; Gurley KE; Yasui Y; Kemp CJ. 2004. p19( Arf) Suppresses Growth, Progression, and Metastasis of Hras-Driven Carcinomas through p53-Dependent and -Independent Pathways. PLoS Biol 2(8):E242. PubMed: 15314658MGI: J:93298
- Kemp CJ; Donehower LA; Bradley A; Balmain A. 1993. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 74(5):813-22. PubMed: 8374952MGI: J:91178
- Kemp CJ; Sun S; Gurley KE. 2001. p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent. Cancer Res 61(1):327-32. PubMed: 11196181MGI: J:67062
- Kemp CJ; Wheldon T; Balmain A. 1994. p53-deficient mice are extremely susceptible to radiation-induced tumorigenesis. Nat Genet 8(1):66-9. PubMed: 7987394MGI: J:19978
- Keyes WM; Vogel H; Koster MI; Guo X; Qi Y; Petherbridge KM; Roop DR; Bradley A; Mills AA. 2006. p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A 103(22):8435-40. PubMed: 16714381MGI: J:110204
- Kim IS; Baek SH. 2010. Mouse models for breast cancer metastasis. Biochem Biophys Res Commun 394(3):443-7. PubMed: 20230796MGI: J:159230
- Kim KH; Sleat DE; Bernard O; Lobel P. 2009. Genetic modulation of apoptotic pathways fails to alter disease course in tripeptidyl-peptidase 1 deficient mice. Neurosci Lett 453(1):27-30. PubMed: 19429009MGI: J:232391
- Kim SH; Shahani N; Bae BI; Sbodio JI; Chung Y; Nakaso K; Paul BD; Sawa A. 2016. Allele-specific regulation of mutant Huntingtin by Wig1, a downstream target of p53. Hum Mol Genet 25(12):2514-2524. PubMed: 27206983MGI: J:237150
- Kissling GE; Malarkey DE; Vallant MK; Johnson JD; Hejtmancik MR; Herbert RA; Boorman GA. 2009. Evaluation of dichloroacetic acid for carcinogenicity in genetically modified Tg.AC hemizygous and p53 haploinsufficient mice. Toxicol Sci 107(1):19-26. PubMed: 18974089MGI: J:143930
- Klein A; Guhl E; Tzeng YJ; Fuhrhop J; Levrero M; Graessmann M; Graessmann A. 2003. HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53. Oncogene 22(19):2910-9. PubMed: 12771941MGI: J:83717
- Klein A; Guhl E; Zollinger R; Tzeng YJ; Wessel R; Hummel M; Graessmann M; Graessmann A. 2005. Gene expression profiling: cell cycle deregulation and aneuploidy do not cause breast cancer formation in WAP-SVT/t transgenic animals. J Mol Med (Berl) 83(5):362-76. PubMed: 15662539MGI: J:224966
- Klein MA; Ruedi D; Nozaki M; Dell EW; Diserens AC; Seelentag W; Janzer RC; Aguzzi A; Hegi ME. 2000. Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant Oncogene 19(47):5329-37. PubMed: 11103934MGI: J:66184
- Klocke BJ; Latham CB; D'Sa C; Roth KA. 2002. p53 deficiency fails to prevent increased programmed cell death in the Bcl-X(L)-deficient nervous system. Cell Death Differ 9(10):1063-8. PubMed: 12232794MGI: J:115543
- Knostman KA; Jhiang SM; Capen CC. 2007. Genetic alterations in thyroid cancer: the role of mouse models. Vet Pathol 44(1):1-14. PubMed: 17197619MGI: J:129329
- Kollmann K; Heller G; Ott RG; Scheicher R; Zebedin-Brandl E; Schneckenleithner C; Simma O; Warsch W; Eckelhart E; Hoelbl A; Bilban M; Zochbauer-Muller S; Malumbres M; Sexl V. 2011. c-JUN promotes BCR-ABL-induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6. Blood 117(15):4065-75. PubMed: 21300982MGI: J:172844
- Kool J; Uren AG; Martins CP; Sie D; de Ridder J; Turner G; van Uitert M; Matentzoglu K; Lagcher W; Krimpenfort P; Gadiot J; Pritchard C; Lenz J; Lund AH; Jonkers J; Rogers J; Adams DJ; Wessels L; Berns A; van Lohuizen M. 2010. Insertional mutagenesis in mice deficient for p15Ink4b, p16Ink4a, p21Cip1, and p27Kip1 reveals cancer gene interactions and correlations with tumor phenotypes. Cancer Res 70(2):520-31. PubMed: 20068150MGI: J:156751
- Kunnev D; Rusiniak ME; Kudla A; Freeland A; Cady GK; Pruitt SC. 2010. DNA damage response and tumorigenesis in Mcm2-deficient mice. Oncogene 29(25):3630-8. PubMed: 20440269MGI: J:162025
- Kuntz C 4th; Kinoshita Y; Beal MF; Donehower LA; Morrison RS. 2000. Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis. Exp Neurol 165(1):184-90. PubMed: 10964497MGI: J:64503
- Kuznetsov SG; Haines DC; Martin BK; Sharan SK. 2009. Loss of Rad51c leads to embryonic lethality and modulation of Trp53-dependent tumorigenesis in mice. Cancer Res 69(3):863-72. PubMed: 19155299MGI: J:144977
- Lam MY; Youngren KK; Nadeau JH. 2004. Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice. Genetics 166(2):925-33. PubMed: 15020477MGI: J:89604
- Lamar JM; Pumiglia KM; DiPersio CM. 2008. An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion. Cancer Res 68(18):7371-9. PubMed: 18794124MGI: J:141217
- Lau J; Ilkhanizadeh S; Wang S; Miroshnikova YA; Salvatierra NA; Wong RA; Schmidt C; Weaver VM; Weiss WA; Persson AI. 2015. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. Cancer Res 75(20):4302-11. PubMed: 26282165MGI: J:225862
- Lauwen MM; Zwaveling S; de Quartel L; Ferreira Mota SC; Grashorn JA; Melief CJ; van der Burg SH; Offringa R. 2008. Self-tolerance does not restrict the CD4+ T-helper response against the p53 tumor antigen. Cancer Res 68(3):893-900. PubMed: 18245492MGI: J:131863
- Lawler J; Miao WM; Duquette M; Bouck N; Bronson RT; Hynes RO. 2001. Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. Am J Pathol 159(5):1949-56. PubMed: 11696456MGI: J:72391
- Le Guezennec X; Brichkina A; Huang YF; Kostromina E; Han W; Bulavin DV. 2012. Wip1-dependent regulation of autophagy, obesity, and atherosclerosis. Cell Metab 16(1):68-80. PubMed: 22768840MGI: J:187401
- Lebel M; Cardiff RD; Leder P. 2001. Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Cancer Res 61(5):1816-9. PubMed: 11280729MGI: J:68488
- Leder A; McMenamin J; Zhou F; Moran JL; Beier DR; Leder P. 2008. Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency. Oncogene 27(17):2456-65. PubMed: 17952114MGI: J:135518
- Lee AF; Ho DK; Zanassi P; Walsh GS; Kaplan DR; Miller FD. 2004. Evidence that DeltaNp73 promotes neuronal survival by p53-dependent and p53-independent mechanisms. J Neurosci 24(41):9174-84. PubMed: 15483136MGI: J:97170
- Lee H; Haque S; Nieto J; Trott J; Inman JK; McCormick S; Chiorazzi N; Mongini PK. 2012. A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion. J Immunol 188(12):6093-108. PubMed: 22611237MGI: J:188962
- Lee JM; Abrahamson JL; Kandel R; Donehower LA; Bernstein A. 1994. Susceptibility to radiation-carcinogenesis and accumulation of chromosomal breakage in p53 deficient mice. Oncogene 9(12):3731-6. PubMed: 7970733MGI: J:21840
- Lee S; Donehower LA; Herron AJ; Moore DD; Fu L. 2010. Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice. PLoS One 5(6):e10995. PubMed: 20539819MGI: J:161808
- Leonova KI; Brodsky L; Lipchick B; Pal M; Novototskaya L; Chenchik AA; Sen GC; Komarova EA; Gudkov AV. 2013. p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs. Proc Natl Acad Sci U S A 110(1):E89-98. PubMed: 23236145MGI: J:192543
- Li G; Tron V; Ho V. 1998. Induction of squamous cell carcinoma in p53-deficient mice after ultraviolet irradiation. J Invest Dermatol 110(1):72-5. PubMed: 9424091MGI: J:45109
- Li H; Choi YJ; Hanes MA; Marple T; Vogel H; Hasty P. 2009. Deleting Ku70 is milder than deleting Ku80 in p53-mutant mice and cells. Oncogene 28(16):1875-8. PubMed: 19330025MGI: J:148795
- Li H; Frappart L; Moll J; Winkler A; Kroll T; Hamann J; Kufferath I; Groth M; Taudien S; Schutte M; Yaspo ML; Heuer H; Lange BM; Platzer M; Zatloukal K; Herrlich P; Ploubidou A. 2016. Impaired Planar Germ Cell Division in the Testis, Caused by Dissociation of RHAMM from the Spindle, Results in Hypofertility and Seminoma. Cancer Res 76(21):6382-6395. PubMed: 27543603MGI: J:237267
- Li L; Abdel Fattah E; Cao G; Ren C; Yang G; Goltsov AA; Chinault AC; Cai WW; Timme TL; Thompson TC. 2008. Glioma pathogenesis-related protein 1 exerts tumor suppressor activities through proapoptotic reactive oxygen species-c-Jun-NH2 kinase signaling. Cancer Res 68(2):434-43. PubMed: 18199537MGI: J:131419
- Li L; Deng B; Xing G; Teng Y; Tian C; Cheng X; Yin X; Yang J; Gao X; Zhu Y; Sun Q; Zhang L; Yang X; He F. 2007. PACT is a negative regulator of p53 and essential for cell growth and embryonic development. Proc Natl Acad Sci U S A 104(19):7951-6. PubMed: 17470788MGI: J:121586
- Li M; Hu J; Heermeier K; Hennighausen L; Furth PA. 1996. Apoptosis and remodeling of mammary gland tissue during involution proceeds through p53-independent pathways. Cell Growth Differ 7(1):13-20. PubMed: 8788029MGI: J:133842
- Li M; Pehar M; Liu Y; Bhattacharyya A; Zhang SC; O'Riordan KJ; Burger C; D'Adamio L; Puglielli L. 2015. The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism. Neurobiol Aging 36(10):2725-36. PubMed: 26174856MGI: J:232261
- Li T; Kon N; Jiang L; Tan M; Ludwig T; Zhao Y; Baer R; Gu W. 2012. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 149(6):1269-83. PubMed: 22682249MGI: J:186159
- Li T; Ramirez K; Palacios R. 1996. Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes. Cell Growth Differ 7(1):107-14. PubMed: 8788039MGI: J:31364
- Li W; Xiao C; Vonderhaar BK; Deng CX. 2007. A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation. Oncogene 26(51):7204-12. PubMed: 17496925MGI: J:129624
- Li X; Deng W; Nail CD; Bailey SK; Kraus MH; Ruppert JM; Lobo-Ruppert SM. 2006. Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Oncogene 25(4):609-21. PubMed: 16158046MGI: J:186380
- Li Y; Choi PS; Casey SC; Felsher DW. 2014. Activation of Cre recombinase alone can induce complete tumor regression. PLoS One 9(9):e107589. PubMed: 25208064MGI: J:223417
- Liang Y; Gao H; Lin SY; Goss JA; Du C; Li K. 2015. Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model. Oncogene 34(33):4368-78. PubMed: 25362854MGI: J:224255
- Lidonnici MR; Corradini F; Waldron T; Bender TP; Calabretta B. 2008. Requirement of c-Myb for p210BCR/ABL-dependent transformation of hematopoietic progenitors and leukemogenesis. Blood 111(9):4771-9. PubMed: 18227349MGI: J:134360
- Lim DS; Hasty P. 1996. A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol Cell Biol 16(12):7133-43. PubMed: 8943369MGI: J:36540
- Lim DS; Vogel H; Willerford DM; Sands AT; Platt KA; Hasty P. 2000. Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol Cell Biol 20(11):3772-80. PubMed: 10805721MGI: J:62142
- Ling BC; Wu J; Miller SJ; Monk KR; Shamekh R; Rizvi TA; Decourten-Myers G; Vogel KS; DeClue JE; Ratner N. 2005. Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis. Cancer Cell 7(1):65-75. PubMed: 15652750MGI: J:95933
- Liu D; Ou L; Clemenson GD Jr; Chao C; Lutske ME; Zambetti GP; Gage FH; Xu Y. 2010. Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol 12(10):993-8. PubMed: 20818388MGI: J:170216
- Liu Q; Guntuku S; Cui XS; Matsuoka S; Cortez D; Tamai K; Luo G; Carattini-Rivera S; DeMayo F; Bradley A; Donehower LA; Elledge SJ. 2000. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev 14(12):1448-59. PubMed: 10859164MGI: J:62919
- Maas SA; Donghia NM; Tompkins K; Foreman O; Mills KD. 2010. ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells. BMC Biol 8:132. PubMed: 20979627MGI: J:225028
- Maddalena AS; Hainfellner JA; Hegi ME; Glatzel M; Aguzzi A. 1999. No complementation between TP53 or RB-1 and v-src in astrocytomas of GFAP-v-src transgenic mice. Brain Pathol 9(4):627-37. PubMed: 10517501MGI: J:59531
- Mahadevaiah SK; Bourc'his D; de Rooij DG; Bestor TH; Turner JM; Burgoyne PS. 2008. Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation. J Cell Biol 182(2):263-76. PubMed: 18663141MGI: J:139518
- Mahler JF; Flagler ND; Malarkey DE; Mann PC; Haseman JK; Eastin W. 1998. Spontaneous and chemically induced proliferative lesions in Tg.AC transgenic and p53-heterozygous mice. Toxicol Pathol 26(4):501-11. PubMed: 9715509MGI: J:51448
- Maier B; Gluba W; Bernier B; Turner T; Mohammad K; Guise T; Sutherland A; Thorner M; Scrable H. 2004. Modulation of mammalian life span by the short isoform of p53. Genes Dev 18(3):306-19. PubMed: 14871929MGI: J:88068
- Mak TW; Hakem A; McPherson JP; Shehabeldin A; Zablocki E; Migon E; Duncan GS; Bouchard D; Wakeham A; Cheung A; Karaskova J; Sarosi I; Squire J; Marth J; Hakem R. 2000. Brcal required for T cell lineage development but not TCR loci rearrangement. Nat Immunol 1(1):77-82. PubMed: 10881179MGI: J:63282
- Manis JP; Dudley D; Kaylor L; Alt FW. 2002. IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells. Immunity 16(4):607-17. PubMed: 11970883MGI: J:113521
- Mao JH; Perez-Losada J; Wu D; Delrosario R; Tsunematsu R; Nakayama KI; Brown K; Bryson S; Balmain A. 2004. Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature 432(7018):775-9. PubMed: 15592418MGI: J:95108
- Mao JH; Wu D; Perez-Losada J; Jiang T; Li Q; Neve RM; Gray JW; Cai WW; Balmain A. 2007. Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice. Cancer Cell 11(2):161-73. PubMed: 17292827MGI: J:118379
- Marino S; Vooijs M; van Der Gulden H; Jonkers J; Berns A. 2000. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum. Genes Dev 14(8):994-1004. PubMed: 10783170MGI: J:61961
- Martin KR; Jokinen MP; Honeycutt HP; Quinn A; Kari FW; Barrett JC; French JE. 2004. Tumor Spectrum in the p53 Heterozygous Zeta Globin-Promoted Tg.AC (v-Ha-ras) Bitransgenic Mouse Model. Toxicol Pathol 32(4):418-25. PubMed: 15204965MGI: J:91642
- Martin KR; Jokinen MP; Honeycutt HP; Quinn A; Kari FW; Barrett JC; French JE. 2004. Tumor Profile of Novel p53 Heterozygous Tg.AC (v-Ha-ras) Bitransgenic Mice Treated with Benzo(a)pyrene and Fed Dietary N-acetyl-L-cysteine (NAC). Toxicol Sci 81(2):293-301. PubMed: 15254344MGI: J:92165
- Martin KR; Saulnier MJ; Kari FW; Barrett JC; French JE. 2002. Timing of supplementation with the antioxidant N-acetyl-L-cysteine reduces tumor multiplicity in novel, cancer-prone p53 haploinsufficient Tg.AC (v-Ha-ras) transgenic mice but has no impact on malignant progression. Nutr Cancer 43(1):59-66. PubMed: 12467136MGI: J:80270
- Martin KR; Trempus C; Saulnier M; Kari FW; Barrett JC; French JE. 2001. Dietary N-acetyl-L-cysteine modulates benzo[a]pyrene-induced skin tumors in cancer-prone p53 haploinsufficient Tg.AC (v-Ha-ras) mice. Carcinogenesis 22(9):1373-8. PubMed: 11532857MGI: J:71732
- Martinez-Bosch N; Iglesias M; Munne-Collado J; Martinez-Caceres C; Moreno M; Guerra C; Yelamos J; Navarro P. 2014. Parp-1 genetic ablation in Ela-myc mice unveils novel roles for Parp-1 in pancreatic cancer. J Pathol 234(2):214-27. PubMed: 24889936MGI: J:214851
- Marty MS; Singh NP; Holsapple MP; Gollapudi BB. 1999. Influence of p53 zygosity on select sperm parameters of the mouse. Mutat Res 427(1):39-45. PubMed: 10354500MGI: J:56532
- Maser RS; Wong KK; Sahin E; Xia H; Naylor M; Hedberg HM; Artandi SE; DePinho RA. 2007. DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol 27(6):2253-65. PubMed: 17145779MGI: J:118902
- Mathe E; Nguyen GH; Funamizu N; He P; Moake M; Croce CM; Hussain SP. 2012. Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide. Int J Cancer 131(3):760-5. PubMed: 22042537MGI: J:186121
- Matijasevic Z; Steinman HA; Hoover K; Jones SN. 2008. MdmX promotes bipolar mitosis to suppress transformation and tumorigenesis in p53-deficient cells and mice. Mol Cell Biol 28(4):1265-73. PubMed: 18039860MGI: J:132640
- Matin A; Collin GB; Varnum DS; Nadeau JH. 1998. Testicular teratocarcinogenesis in mice--a review. APMIS 106(1):174-82. PubMed: 9524576MGI: J:46683
- Matsumoto A; Susaki E; Onoyama I; Nakayama K; Hoshino M; Nakayama KI. 2011. Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice. Mol Cell Biol 31(20):4176-92. PubMed: 21844226MGI: J:178174
- Matsumoto A; Takeishi S; Nakayama KI. 2014. p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling. Blood 123(22):3429-39. PubMed: 24652995MGI: J:211680
- Matsusaka H; Ide T; Matsushima S; Ikeuchi M; Kubota T; Sunagawa K; Kinugawa S; Tsutsui H. 2006. Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice. Cardiovasc Res 70(3):457-65. PubMed: 16533502MGI: J:111145
- Mattison J; Kool J; Uren AG; de Ridder J; Wessels L; Jonkers J; Bignell GR; Butler A; Rust AG; Brosch M; Wilson CH; van der Weyden L; Largaespada DA; Stratton MR; Futreal PA; van Lohuizen M; Berns A; Collier LS; Hubbard T; Adams DJ. 2010. Novel candidate cancer genes identified by a large-scale cross-species comparative oncogenomics approach. Cancer Res 70(3):883-95. PubMed: 20103622MGI: J:156861
- Matzinger SA; Crist KA; Stoner GD; Anderson MW; Pereira MA; Steele VE; Kelloff GJ; Lubet RA; You M. 1995. K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate. Carcinogenesis 16(10):2487-92. PubMed: 7586156MGI: J:29998
- McCormick DL; Ryan BM; Findlay JC; Gauger JR; Johnson TR; Morrissey RL; Boorman GA. 1998. Exposure to 60 Hz magnetic fields and risk of lymphoma in PIM transgenic and TSG-p53 (p53 knockout) mice. Carcinogenesis 19(9):1649-53. PubMed: 9771937MGI: J:49894
- McPherson JP; Hande MP; Poonepalli A; Lemmers B; Zablocki E; Migon E; Shehabeldin A; Porras A; Karaskova J; Vukovic B; Squire J; Hakem R. 2006. A role for Brca1 in chromosome end maintenance. Hum Mol Genet 15(6):831-8. PubMed: 16446310MGI: J:106759
- McPherson JP; Lemmers B; Hirao A; Hakem A; Abraham J; Migon E; Matysiak-Zablocki E; Tamblyn L; Sanchez-Sweatman O; Khokha R; Squire J; Hande MP; Mak TW; Hakem R. 2004. Collaboration of Brca1 and Chk2 in tumorigenesis. Genes Dev 18(10):1144-53. PubMed: 15131084MGI: J:90512
- Merritt AJ; Allen TD; Potten CS; Hickman JA. 1997. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation. Oncogene 14(23):2759-66. PubMed: 9190891MGI: J:41195
- Molyneux G; Geyer FC; Magnay FA; McCarthy A; Kendrick H; Natrajan R; Mackay A; Grigoriadis A; Tutt A; Ashworth A; Reis-Filho JS; Smalley MJ. 2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7(3):403-17. PubMed: 20804975MGI: J:164435
- Moore L; Lu X; Ghebranious N; Tyner S; Donehower LA. 2007. Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity. Mech Ageing Dev 128(11-12):717-30. PubMed: 18061646MGI: J:141538
- Moore L; Venkatachalam S; Vogel H; Watt JC; Wu CL; Steinman H; Jones SN; Donehower LA. 2003. Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis. Oncogene 22(49):7831-7. PubMed: 14586409MGI: J:86658
- Mori N; Yamate J; Stassen AP; Oka S; Okumoto M; Tsubura A; Akamatsu T; Sakuma S; Demant P. 1999. Modulations of glucocorticoid-induced apoptosis linked to the p53 deletion and to the apoptosis susceptibility gene Rapop1 (Radiation-induced apoptosis 1). Oncogene 18(29):4282-5. PubMed: 10435642MGI: J:56729
- Mori N; Yamate J; Umesako SI; Hong DP; Okumoto M; Nakao R. 2003. Preferential Induction of Mammary Tumors in p53 Hemizygous BALB/c Mice by Fractionated Irradiation of a Sub-lethal Dose of X-rays. J Radiat Res (Tokyo) 44(3):249-254. PubMed: 14646229MGI: J:87532
- Morita M; Gravel SP; Chenard V; Sikstrom K; Zheng L; Alain T; Gandin V; Avizonis D; Arguello M; Zakaria C; McLaughlan S; Nouet Y; Pause A; Pollak M; Gottlieb E; Larsson O; St-Pierre J; Topisirovic I; Sonenberg N. 2013. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metab 18(5):698-711. PubMed: 24206664MGI: J:206172
- Morrison RS; Wenzel HJ; Kinoshita Y; Robbins CA; Donehower LA; Schwartzkroin PA. 1996. Loss of the p53 tumor suppressor gene protects neurons from kainate-induced cell death. J Neurosci 16(4):1337-45. PubMed: 8778285MGI: J:110591
- Mudhasani R; Zhu Z; Hutvagner G; Eischen CM; Lyle S; Hall LL; Lawrence JB; Imbalzano AN; Jones SN. 2008. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol 181(7):1055-63. PubMed: 18591425MGI: J:139257
- Mulay SR; Thomasova D; Ryu M; Anders HJ. 2012. MDM2 (murine double minute-2) links inflammation and tubular cell healing during acute kidney injury in mice. Kidney Int 81(12):1199-211. PubMed: 22297670MGI: J:198187
- Mulder JE; Bondy GS; Mehta R; Massey TE. 2014. Up-regulation of nucleotide excision repair in mouse lung and liver following chronic exposure to aflatoxin B(1) and its dependence on p53 genotype. Toxicol Appl Pharmacol 275(2):96-103. PubMed: 24380836MGI: J:211958
- Munoz-Fontela C; Macip S; Martinez-Sobrido L; Brown L; Ashour J; Garcia-Sastre A; Lee SW; Aaronson SA. 2008. Transcriptional role of p53 in interferon-mediated antiviral immunity. J Exp Med 205(8):1929-38. PubMed: 18663127MGI: J:139350
- Murphy SP; Lee RJ; McClean ME; Pemberton HE; Uo T; Morrison RS; Bastian C; Baltan S. 2014. MS-275, a Class I histone deacetylase inhibitor, protects the p53-deficient mouse against ischemic injury. J Neurochem 129(3):509-15. PubMed: 24147654MGI: J:208827
- Murray-Zmijewski F; Lane DP; Bourdon JC. 2006. p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ 13(6):962-72. PubMed: 16601753MGI: J:126410
- Nahari D; McDaniel LD; Task LB; Daniel RL; Velasco-Miguel S; Friedberg EC. 2004. Mutations in the Trp53 gene of UV-irradiated Xpc mutant mice suggest a novel Xpc-dependent DNA repair process. DNA Repair (Amst) 3(4):379-86. PubMed: 15010313MGI: J:88558
- Nakles RE; Kallakury BV; Furth PA. 2013. The PPARgamma Agonist Efatutazone Increases the Spectrum of Well-Differentiated Mammary Cancer Subtypes Initiated by Loss of Full-Length BRCA1 in Association with TP53 Haploinsufficiency. Am J Pathol 182(6):1976-85. PubMed: 23664366MGI: J:197441
- Ng SH; Maas SA; Petkov PM; Mills KD; Paigen K. 2009. Colocalization of somatic and meiotic double strand breaks near the Myc oncogene on mouse chromosome 15. Genes Chromosomes Cancer 48(10):925-30. PubMed: 19603522MGI: J:153912
- Nikitin AY; Liu CY; Flesken-Nikitin A; Chen CF; Chen PL; Lee WH. 2002. Cell Lineage-specific Effects Associated with Multiple Deficiencies of Tumor Susceptibility Genes in Msh2(-/-)Rb(+/-) Mice. Cancer Res 62(18):5134-8. PubMed: 12234974MGI: J:79016
- Nilsson LM; Forshell TZ; Rimpi S; Kreutzer C; Pretsch W; Bornkamm GW; Nilsson JA. 2012. Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis. PLoS Genet 8(3):e1002573. PubMed: 22438825MGI: J:183477
- Nishikawa T; Salim EI; Morimura K; Kaneko M; Ogawa M; Kinoshita A; Osugi H; Kinoshita H; Fukushima S. 2003. High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine. Cancer Lett 194(1):45-54. PubMed: 12706858MGI: J:83072
- Nishino H; Knoll A; Buettner VL; Frisk CS; Maruta Y; Haavik J; Sommer SS. 1995. p53 wild-type and p53 nullizygous Big Blue transgenic mice have similar frequencies and patterns of observed mutation in liver, spleen and brain. Oncogene 11(2):263-70. PubMed: 7624143MGI: J:28628
- Nister M; Tang M; Zhang XQ; Yin C; Beeche M; Hu X; Enblad G; van Dyke T; Wahl GM. 2005. p53 must be competent for transcriptional regulation to suppress tumor formation. Oncogene 24(22):3563-73. PubMed: 15750633MGI: J:153341
- O'Leary KA; Rugowski DE; Sullivan R; Schuler LA. 2014. Prolactin cooperates with loss of p53 to promote claudin-low mammary carcinomas. Oncogene 33(23):3075-82. PubMed: 23873024MGI: J:212620
- O'Reilly MA; Staversky RJ; Watkins RH; Reed CK; de Mesy Jensen KL; Finkelstein JN; Keng PC. 2001. The cyclin-dependent kinase inhibitor p21 protects the lung from oxidative stress. Am J Respir Cell Mol Biol 24(6):703-10. PubMed: 11415935MGI: J:114407
- Odorisio T; Rodriguez TA; Evans EP; Clarke AR; Burgoyne PS. 1998. The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis [see comments] Nat Genet 18(3):257-61. PubMed: 9500548MGI: J:46385
- Ohgaki H; Fukuda M; Tohma Y; Huang H; Stoica G; Tatematsu M; Donehower LA. 2000. Effect of intragastric application of N-methylnitrosourea in p53 knockout mice. Mol Carcinog 28(2):97-101. PubMed: 10900466MGI: J:63574
- Ohtsuka H; Sakamoto A; Pan J; Inage S; Horigome S; Ichii H; Arima M; Hatano M; Okada S; Tokuhisa T. 2011. Bcl6 is required for the development of mouse CD4+ and CD8alpha+ dendritic cells. J Immunol 186(1):255-63. PubMed: 21131418MGI: J:168803
- Okazuka K; Wakabayashi Y; Kashihara M; Inoue J; Sato T; Yokoyama M; Aizawa S; Aizawa Y; Mishima Y; Kominami R. 2005. p53 prevents maturation of T cell development to the immature CD4(-)CD8(+) stage in Bcl11b(-/-) mice. Biochem Biophys Res Commun 328(2):545-549. PubMed: 15694382MGI: J:96179
- Ozaki K; Sukata T; Yamamoto S; Uwagawa S; Seki T; Kawasaki H ; Yoshitake A ; Wanibuchi H ; Koide A ; Mori Y ; Fukushima S. 1998. High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele. Cancer Res 58(17):3806-11. PubMed: 9731488MGI: J:49595
- Ozaki M; Ozaki K; Watanabe T; Uwagawa S; Okuno Y; Shirai T. 2005. Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains. Toxicol Pathol 33(2):267-71. PubMed: 15902970MGI: J:98988
- Pamidi A; Cardoso R; Hakem A; Matysiak-Zablocki E; Poonepalli A; Tamblyn L; Perez-Ordonez B; Hande MP; Sanchez O; Hakem R. 2007. Functional Interplay of p53 and Mus81 in DNA Damage Responses and Cancer. Cancer Res 67(18):8527-35. PubMed: 17875692MGI: J:124877
- Papadopoulos P; Gutierrez L; van der Linden R; Kong-A-San J; Maas A; Drabek D; Patrinos GP; Philipsen S; Grosveld F. 2012. A dual reporter mouse model of the human beta-globin locus: applications and limitations. PLoS One 7(12):e51272. PubMed: 23272095MGI: J:195648
- Parker SB; Eichele G; Zhang P; Rawls A; Sands AT; Bradley A; Olson EN; Harper JW; Elledge SJ. 1995. p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells [see comments] Science 267(5200):1024-7. PubMed: 7863329MGI: J:37752
- Pehar M; Ko MH; Li M; Scrable H; Puglielli L. 2014. P44, the 'longevity-assurance' isoform of P53, regulates tau phosphorylation and is activated in an age-dependent fashion. Aging Cell 13(3):449-56. PubMed: 24341977MGI: J:217255
- Pehar M; O'Riordan KJ; Burns-Cusato M; Andrzejewski ME; del Alcazar CG; Burger C; Scrable H; Puglielli L. 2010. Altered longevity-assurance activity of p53:p44 in the mouse causes memory loss, neurodegeneration and premature death. Aging Cell 9(2):174-90. PubMed: 20409077MGI: J:221852
- Perier C; Bove J; Wu DC; Dehay B; Choi DK; Jackson-Lewis V; Rathke-Hartlieb S; Bouillet P; Strasser A; Schulz JB; Przedborski S; Vila M. 2007. Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease. Proc Natl Acad Sci U S A 104(19):8161-6. PubMed: 17483459MGI: J:121592
- Perkins SN; Hursting SD; Haines DC; James SJ; Miller BJ; Phang JM. 1997. Chemoprevention of spontaneous tumorigenesis in nullizygous p53-deficient mice by dehydroepiandrosterone and its analog 16alpha-fluoro-5-androsten-17-one. Carcinogenesis 18(5):989-94. PubMed: 9163685MGI: J:90934
- Perkins SN; Hursting SD; Phang JM; Haines DC. 1998. Calorie restriction reduces ulcerative dermatitis and infection-related mortality in p53-deficient and wild-type mice. J Invest Dermatol 111(2):292-6. PubMed: 9699732MGI: J:48948
- Persson AI; Petritsch C; Swartling FJ; Itsara M; Sim FJ; Auvergne R; Goldenberg DD; Vandenberg SR; Nguyen KN; Yakovenko S; Ayers-Ringler J; Nishiyama A; Stallcup WB; Berger MS; Bergers G; McKnight TR; Goldman SA; Weiss WA. 2010. Non-stem cell origin for oligodendroglioma. Cancer Cell 18(6):669-82. PubMed: 21156288MGI: J:167608
- Petibone DM; Kulkarni RM; Chang CW; Chen JJ; Morris SM. 2012. Evaluation of p53 genotype on gene expression in the testis, liver, and heart from male C57BL/6 mice. Transgenic Res 21(2):257-63. PubMed: 21656205MGI: J:183577
- Petroulakis E; Parsyan A; Dowling RJ; LeBacquer O; Martineau Y; Bidinosti M; Larsson O; Alain T; Rong L; Mamane Y; Paquet M; Furic L; Topisirovic I; Shahbazian D; Livingstone M; Costa-Mattioli M; Teodoro JG; Sonenberg N. 2009. p53-dependent translational control of senescence and transformation via 4E-BPs. Cancer Cell 16(5):439-46. PubMed: 19878875MGI: J:153944
- Pfefferle AD; Herschkowitz JI; Usary J; Harrell JC; Spike BT; Adams JR; Torres-Arzayus MI; Brown M; Egan SE; Wahl GM; Rosen JM; Perou CM. 2013. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol 14(11):R125. PubMed: 24220145MGI: J:227323
- Philipp-Staheli J; Kim KH; Liggitt D; Gurley KE; Longton G; Kemp CJ. 2004. Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development. Oncogene 23(4):905-13. PubMed: 14647411MGI: J:87536
- Pietras EM; Lakshminarasimhan R; Techner JM; Fong S; Flach J; Binnewies M; Passegue E. 2014. Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons. J Exp Med 211(2):245-62. PubMed: 24493802MGI: J:208438
- Ponnamperuma RM; King KE; Elsir T; Glick AB; Wahl GM; Nister M; Weinberg WC. 2009. The transcriptional regulatory function of p53 is essential for suppression of mouse skin carcinogenesis and can be dissociated from effects on TGF-beta-mediated growth regulation. J Pathol 219(2):263-74. PubMed: 19718706MGI: J:153066
- Przemeck SM; Duckworth CA; Pritchard DM. 2007. Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am J Physiol Gastrointest Liver Physiol 292(2):G620-7. PubMed: 17068116MGI: J:124814
- Qin B; Minter-Dykhouse K; Yu J; Zhang J; Liu T; Zhang H; Lee S; Kim J; Wang L; Lou Z. 2015. DBC1 functions as a tumor suppressor by regulating p53 stability. Cell Rep 10(8):1324-34. PubMed: 25732823MGI: J:222111
- Raciti M; Granzotto M; Duc MD; Fimiani C; Cellot G; Cherubini E; Mallamaci A. 2013. Reprogramming fibroblasts to neural-precursor-like cells by structured overexpression of pallial patterning genes. Mol Cell Neurosci 57:42-53. PubMed: 24128663MGI: J:215737
- Ramiro AR; Jankovic M; Callen E; Difilippantonio S; Chen HT; McBride KM; Eisenreich TR; Chen J; Dickins RA; Lowe SW; Nussenzweig A; Nussenzweig MC. 2006. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440(7080):105-9. PubMed: 16400328MGI: J:106450
- Ranaldi R; Palma S; Tanzarella C; Lascialfari A; Cinelli S; Pacchierotti F. 2007. Effect of p53 haploinsufficiency on melphalan-induced genotoxic effects in mouse bone marrow and peripheral blood. Mutat Res 615(1-2):57-65. PubMed: 17109898MGI: J:118156
- Ratnam S; Bozek G; Nicolae D; Storb U. 2010. The pattern of somatic hypermutation of Ig genes is altered when p53 is inactivated. Mol Immunol 47(16):2611-8. PubMed: 20691478MGI: J:167102
- Rees D; Nesbitt MN; Goldberg EH. 1994. Skn 2 is linked to Myb on chromosome 10 of the mouse. Immunogenetics 39(5):363-6. PubMed: 8168855MGI: J:18183
- Regeling A; Armata HL; Gallant J; Jones SN; Sluss HK. 2011. Mice defective in p53 nuclear localization signal 1 exhibit exencephaly. Transgenic Res 20(4):899-912. PubMed: 21127973MGI: J:175018
- Ridgeway AG; McMenamin J; Leder P. 2006. P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells. Oncogene 25(25):3518-27. PubMed: 16434961MGI: J:112291
- Robanus-Maandag E; Giovannini M; van der Valk M; Niwa-Kawakita M; Abramowski V; Antonescu C; Thomas G; Berns A. 2004. Synergy of Nf2 and p53 mutations in development of malignant tumours of neural crest origin. Oncogene 23(39):6541-7. PubMed: 15221010MGI: J:92413
- Roberts SA; Strande N; Burkhalter MD; Strom C; Havener JM; Hasty P; Ramsden DA. 2010. Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends. Nature 464(7292):1214-7. PubMed: 20383123MGI: J:159280
- Rong S; Donehower LA; Hansen MF; Strong L; Tainsky M; Jeffers M; Resau JH; Hudson E; Tsarfaty I; Vande Woude GF. 1995. Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients. Cancer Res 55(9):1963-70. PubMed: 7728766MGI: J:24926
- Rooney S; Sekiguchi J; Whitlow S; Eckersdorff M; Manis JP; Lee C; Ferguson DO; Alt FW. 2004. Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. Proc Natl Acad Sci U S A 101(8):2410-5. PubMed: 14983023MGI: J:88663
- Rounbehler RJ; Rogers PM; Conti CJ; Johnson DG. 2002. Inactivation of E2f1 enhances tumorigenesis in a Myc transgenic model. Cancer Res 62(11):3276-81. PubMed: 12036945MGI: J:77029
- Ruddell A; Kelly-Spratt KS; Furuya M; Parghi SS; Kemp CJ. 2008. p19/Arf and p53 suppress sentinel lymph node lymphangiogenesis and carcinoma metastasis. Oncogene 27(22):3145-55. PubMed: 18059331MGI: J:135611
- Russell JL; Weaks RL; Berton TR; Johnson DG. 2006. E2F1 suppresses skin carcinogenesis via the ARF-p53 pathway. Oncogene 25(6):867-76. PubMed: 16205640MGI: J:105657
- Ryan A; Scrable H. 2008. Mutant alleles of HD improve the life span of p53(-/-) mice. Mech Ageing Dev 129(4):238-41. PubMed: 18242663MGI: J:136023
- Ryan AB; Zeitlin SO; Scrable H. 2006. Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis. Neurobiol Dis 24(2):419-27. PubMed: 16978870MGI: J:114544
- Saito M; Kumamoto K; Robles AI; Horikawa I; Furusato B; Okamura S; Goto A; Yamashita T; Nagashima M; Lee TL; Baxendale VJ; Rennert OM; Takenoshita S; Yokota J; Sesterhenn IA; Trivers GE; Hussain SP; Harris CC. 2010. Targeted disruption of Ing2 results in defective spermatogenesis and development of soft-tissue sarcomas. PLoS One 5(11):e15541. PubMed: 21124965MGI: J:167311
- Sakai H; Tsukamoto T; Yamamoto M; Shirai N; Iidaka T; Hirata A; Yanai T; Masegi T; Donehower LA; Tatematsu M. 2003. High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine. J Cancer Res Clin Oncol 129(6):335-40. PubMed: 12743811MGI: J:84233
- Saleem A; Adhihetty PJ; Hood DA. 2009. Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle. Physiol Genomics 37(1):58-66. PubMed: 19106183MGI: J:157970
- Saleem A; Carter HN; Hood DA. 2014. p53 is necessary for the adaptive changes in cellular milieu subsequent to an acute bout of endurance exercise. Am J Physiol Cell Physiol 306(3):C241-9. PubMed: 24284795MGI: J:210903
- Saleem A; Hood DA. 2013. Acute exercise induces tumour suppressor protein p53 translocation to the mitochondria and promotes a p53-Tfam-mitochondrial DNA complex in skeletal muscle. J Physiol 591(Pt 14):3625-36. PubMed: 23690562MGI: J:212139
- Saleem A; Iqbal S; Zhang Y; Hood DA. 2015. Effect of p53 on mitochondrial morphology, import, and assembly in skeletal muscle. Am J Physiol Cell Physiol 308(4):C319-29. PubMed: 25472962MGI: J:223857
- Salz W; Eisenberg D; Plescia J; Garlick DS; Weiss RM; Wu XR; Sun TT; Altieri DC. 2005. A survivin gene signature predicts aggressive tumor behavior. Cancer Res 65(9):3531-4. PubMed: 15867343MGI: J:98361
- Sanders JM; Burka LT; Chanas B; Matthews HB. 2001. Comparative xenobiotic metabolism between Tg.AC and p53+/- genetically altered mice and their respective wild types. Toxicol Sci 61(1):54-61. PubMed: 11294974MGI: J:128799
- Sands AT; Suraokar MB; Sanchez A; Marth JE; Donehower LA; Bradley A. 1995. p53 deficiency does not affect the accumulation of point mutations in a transgene target. Proc Natl Acad Sci U S A 92(18):8517-21. PubMed: 7667322MGI: J:29025
- Sansom OJ; Bishop SM; Bird A; Clarke AR. 2005. MBD2 deficiency does not accelerate p53 mediated lymphomagenesis. Oncogene 24(14):2430-2. PubMed: 15735763MGI: J:97526
- Scherthan H; Jerratsch M; Dhar S; Wang YA; Goff SP; Pandita TK. 2000. Meiotic telomere distribution and sertoli cell nuclear architecture are altered in atm- and atm-p53-deficient mice Mol Cell Biol 20(20):7773-83. PubMed: 11003672MGI: J:64777
- Schito ML; Demidov ON; Saito S; Ashwell JD; Appella E. 2006. Wip1 phosphatase-deficient mice exhibit defective T cell maturation due to sustained p53 activation. J Immunol 176(8):4818-25. PubMed: 16585576MGI: J:131158
- Schwarzkopf M; Coletti D; Sassoon D; Marazzi G. 2006. Muscle cachexia is regulated by a p53-PW1/Peg3-dependent pathway. Genes Dev 20(24):3440-52. PubMed: 17182869MGI: J:116682
- Sell S. 2003. Mouse models to study the interaction of risk factors for human liver cancer. Cancer Res 63(22):7553-62. PubMed: 14633666MGI: J:86647
- Settembre C; Zoncu R; Medina DL; Vetrini F; Erdin S; Erdin S; Huynh T; Ferron M; Karsenty G; Vellard MC; Facchinetti V; Sabatini DM; Ballabio A. 2012. A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J 31(5):1095-108. PubMed: 22343943MGI: J:182149
- Shen SX; Weaver Z; Xu X; Li C; Weinstein M; Chen L; Guan XY; Ried T; Deng CX. 1998. A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability. Oncogene 17(24):3115-24. PubMed: 9872327MGI: J:51834
- Shick L; Carman JH; Choi JK; Somasundaram K; Burrell M; Hill DE; Zeng YX; Wang Y; Wiman KG; Salhany K; Kadesch TR; Monroe JG; Donehower LA; el-Deiry WS. 1997. Decreased immunoglobulin deposition in tumors and increased immature B cells in p53-null mice. Cell Growth Differ 8(2):121-31. PubMed: 9040934MGI: J:133841
- Shinohara S; Rothstein JL. 2004. Interleukin 24 is induced by the RET/PTC3 oncoprotein and is an autocrine growth factor for epithelial cells. Oncogene 23(45):7571-9. PubMed: 15326486MGI: J:93839
- Shirai N; Tsukamoto T; Yamamoto M; Iidaka T; Sakai H; Yanai T; Masegi T; Donehower LA; Tatematsu M. 2002. Elevated susceptibility of the p53 knockout mouse esophagus to methyl-N-amylnitrosamine carcinogenesis. Carcinogenesis 23(9):1541-7. PubMed: 12189199MGI: J:78528
- Shreeram S; Hee WK; Demidov ON; Kek C; Yamaguchi H; Fornace AJ Jr; Anderson CW; Appella E; Bulavin DV. 2006. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med 203(13):2793-9. PubMed: 17158963MGI: J:120284
- Shukla V; Coumoul X; Cao L; Wang RH; Xiao C; Xu X; Ando S; Yakar S; Leroith D; Deng C. 2006. Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. Cancer Res 66(14):7151-7. PubMed: 16849561MGI: J:112124
- Singh P; Alley TL; Wright SM; Kamdar S; Schott W; Wilpan RY; Mills KD; Graber JH. 2009. Global changes in processing of mRNA 3' untranslated regions characterize clinically distinct cancer subtypes. Cancer Res 69(24):9422-30. PubMed: 19934316MGI: J:155538
- Singh S; Ramamoorthy M; Vaughan C; Yeudall WA; Deb S; Palit Deb S. 2013. Human oncoprotein MDM2 activates the Akt signaling pathway through an interaction with the repressor element-1 silencing transcription factor conferring a survival advantage to cancer cells. Cell Death Differ 20(4):558-66. PubMed: 23238568MGI: J:228265
- Sistrunk C; Kim SH; Wang X; Lee SH; Kim Y; Macias E; Rodriguez-Puebla ML. 2013. Skp2 Deficiency Inhibits Chemical Skin Tumorigenesis Independent of p27(Kip1) Accumulation. Am J Pathol 182(5):1854-64. PubMed: 23474082MGI: J:195539
- Smith AP; Henze M; Lee JA; Osborn KG; Keck JM; Tedesco D; Bortner DM; Rosenberg MP; Reed SI. 2006. Deregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland. Oncogene 25(55):7245-59. PubMed: 16751806MGI: J:147407
- Smolen GA; Muir B; Mohapatra G; Barmettler A; Kim WJ; Rivera MN; Haserlat SM; Okimoto RA; Kwak E; Dahiya S; Garber JE; Bell DW; Sgroi DC; Chin L; Deng CX; Haber DA. 2006. Frequent met oncogene amplification in a Brca1/Trp53 mouse model of mammary tumorigenesis. Cancer Res 66(7):3452-5. PubMed: 16585167MGI: J:108217
- Song H; Hollstein M; Xu Y. 2007. p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat Cell Biol 9(5):573-80. PubMed: 17417627MGI: J:126497
- Soond SM; Carroll C; Townsend PA; Sayan E; Melino G; Behrmann I; Knight RA; Latchman DS; Stephanou A. 2007. STAT1 regulates p73-mediated Bax gene expression. FEBS Lett 581(6):1217-26. PubMed: 17346710MGI: J:121450
- Spalding JW; French JE; Stasiewicz S; Furedi-Machacek M; Conner F; Tice RR; Tennant RW. 2000. Responses of transgenic mouse lines p53(+/-) and Tg.AC to agents tested in conventional carcinogenicity bioassays. Toxicol Sci 53(2):213-23. PubMed: 10696769MGI: J:61225
- Steinman HA; Hoover KM; Keeler ML; Sands AT; Jones SN. 2005. Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development. Oncogene 24(53):7935-40. PubMed: 16027727MGI: J:103425
- Stepniak E; Ricci R; Eferl R; Sumara G; Sumara I; Rath M; Hui L; Wagner EF. 2006. c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev 20(16):2306-14. PubMed: 16912279MGI: J:111671
- Stoddart A; Fernald AA; Wang J; Davis EM; Karrison T; Anastasi J; Le Beau MM. 2014. Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice. Blood 123(7):1069-78. PubMed: 24381225MGI: J:208692
- Storer RD; French JE; Haseman J; Hajian G; LeGrand EK; Long GG; Mixson LA; Ochoa R; Sagartz JE; Soper KA. 2001. P53+/- hemizygous knockout mouse: overview of available data. Toxicol Pathol 29 Suppl:30-50. PubMed: 11695560MGI: J:73019
- Su W; Hopkins S; Nesser NK; Sopher B; Silvestroni A; Ammanuel S; Jayadev S; Moller T; Weinstein J; Garden GA. 2014. The p53 transcription factor modulates microglia behavior through microRNA-dependent regulation of c-Maf. J Immunol 192(1):358-66. PubMed: 24319262MGI: J:207158
- Su X; Chakravarti D; Flores ER. 2013. p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer 13(2):136-43. PubMed: 23344544MGI: J:193489
- Sugiarto S; Persson AI; Munoz EG; Waldhuber M; Lamagna C; Andor N; Hanecker P; Ayers-Ringler J; Phillips J; Siu J; Lim DA; Vandenberg S; Stallcup W; Berger MS; Bergers G; Weiss WA; Petritsch C. 2011. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell 20(3):328-40. PubMed: 21907924MGI: J:175969
- Sukata T; Ozaki K; Uwagawa S; Seki T; Wanibuchi H; Yamamoto S; Okuno Y; Fukushima S. 2000. Organ-specific, carcinogen-induced increases in cell proliferation in p53-deficient mice. Cancer Res 60(1):74-9. PubMed: 10646856MGI: J:59949
- Suzuki K; Murphy SH; Xia Y; Yokota M; Nakagomi D; Liu F; Verma IM; Nakajima H. 2011. Tumor suppressor p53 functions as a negative regulator in IgE-mediated mast cell activation. PLoS One 6(9):e25412. PubMed: 21966524MGI: J:177915
- Swann JB; Uldrich AP; van Dommelen S; Sharkey J; Murray WK; Godfrey DI; Smyth MJ. 2009. Type I natural killer T cells suppress tumors caused by p53 loss in mice. Blood 113(25):6382-5. PubMed: 19234138MGI: J:150094
- Takeda H; Miyoshi H; Kojima Y; Oshima M; Taketo MM. 2006. Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Oncogene 25(12):1816-20. PubMed: 16278673MGI: J:107275
- Takemura N; Kawasaki T; Kunisawa J; Sato S; Lamichhane A; Kobiyama K; Aoshi T; Ito J; Mizuguchi K; Karuppuchamy T; Matsunaga K; Miyatake S; Mori N; Tsujimura T; Satoh T; Kumagai Y; Kawai T; Standley DM; Ishii KJ; Kiyono H; Akira S; Uematsu S. 2014. Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome. Nat Commun 5:3492. PubMed: 24637670MGI: J:210311
- Taketani K; Kawauchi J; Tanaka-Okamoto M; Ishizaki H; Tanaka Y; Sakai T; Miyoshi J; Maehara Y; Kitajima S. 2012. Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells. Oncogene 31(17):2210-21. PubMed: 21927023MGI: J:228274
- Tateossian H; Hardisty-Hughes RE; Morse S; Romero MR; Hilton H; Dean C; Brown SD. 2009. Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant. Pathogenetics 2(1):5. PubMed: 19580641MGI: J:156253
- Tateossian H; Morse S; Simon MM; Dean CH; Brown SD. 2015. Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung. Dis Model Mech 8(12):1531-42. PubMed: 26471094MGI: J:226978
- Tazawa H; Tatemichi M; Sawa T; Gilibert I; Ma N; Hiraku Y; Donehower LA; Ohgaki H; Kawanishi S; Ohshima H. 2007. Oxidative and nitrative stress caused by subcutaneous implantation of a foreign body accelerates sarcoma development in Trp53+/- mice. Carcinogenesis 28(1):191-8. PubMed: 16857722MGI: J:116514
- Terrile M; Bryan K; Vaughan L; Hallsworth A; Webber H; Chesler L; Stallings RL. 2011. miRNA expression profiling of the murine TH-MYCN neuroblastoma model reveals similarities with human tumors and identifies novel candidate miRNAs. PLoS One 6(12):e28356. PubMed: 22164278MGI: J:182261
- Theurillat JP; Hainfellner J; Maddalena A; Weissenberger J; Aguzzi A. 1999. Early induction of angiogenetic signals in gliomas of GFAP-v-src transgenic mice. Am J Pathol 154(2):581-90. PubMed: 10027415MGI: J:52816
- Thompson TC; Park SH; Timme TL; Ren C; Eastham JA; Donehower LA; Bradley A; Kadmon D; Yang G. 1995. Loss of p53 function leads to metastasis in ras+myc-initiated mouse prostate cancer. Oncogene 10(5):869-79. PubMed: 7534899MGI: J:23798
- Timme TL; Thompson TC. 1994. Rapid allelotype analysis of p53 knockout mice. Biotechniques 17(3):460,462-3. PubMed: 7818898MGI: J:23193
- Toledo F; Krummel KA; Lee CJ; Liu CW; Rodewald LW; Tang M; Wahl GM. 2006. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell 9(4):273-85. PubMed: 16616333MGI: J:108183
- Toledo F; Lee CJ; Krummel KA; Rodewald LW; Liu CW; Wahl GM. 2007. Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol 27(4):1425-32. PubMed: 17158931MGI: J:118244
- Toledo F; Liu CW; Lee CJ; Wahl GM. 2006. RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. Nucleic Acids Res 34(13):e92. PubMed: 16870721MGI: J:116011
- Tommasi S; Besaratinia A; Wilczynski SP; Pfeifer GP. 2010. Loss of Rassf1a enhances p53-mediated tumor predisposition and accelerates progression to aneuploidy. Oncogene :. PubMed: 20890300MGI: J:164640
- Tomoda K; Yoneda-Kato N; Fukumoto A; Yamanaka S; Kato JY. 2004. Multiple functions of Jab1 are required for early embryonic development and growth potential in mice. J Biol Chem 279(41):43013-8. PubMed: 15299027MGI: J:93979
- Tong WM; Hande MP; Lansdorp PM; Wang ZQ. 2001. DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. Mol Cell Biol 21(12):4046-54. PubMed: 11359911MGI: J:69252
- Tong WM; Ohgaki H; Huang H; Granier C; Kleihues P; Wang ZQ. 2003. Null Mutation of DNA Strand Break-Binding Molecule Poly(ADP-ribose) Polymerase Causes Medulloblastomas in p53(-/-) Mice. Am J Pathol 162(1):343-52. PubMed: 12507917MGI: J:80903
- Tong WM; Yang YG; Cao WH; Galendo D; Frappart L; Shen Y; Wang ZQ. 2007. Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice. Oncogene 26(26):3857-67. PubMed: 17160013MGI: J:122892
- Trimmer PA; Smith TS; Jung AB; Bennett JP Jr. 1996. Dopamine neurons from transgenic mice with a knockout of the p53 gene resist MPTP neurotoxicity. Neurodegeneration 5(3):233-9. PubMed: 8910901MGI: J:36529
- Tsai MS; Chiu YT; Wang SH; Hsieh-Li HM; Li H. 2006. Abolishing Trp53-dependent apoptosis does not benefit spinal muscular atrophy model mice. Eur J Hum Genet 14(3):372-5. PubMed: 16391561MGI: J:129232
- Tuveson DA; Hingorani SR. 2005. Ductal pancreatic cancer in humans and mice. Cold Spring Harb Symp Quant Biol 70:65-72. PubMed: 16869739MGI: J:116752
- Tyner SD; Choi J; Laucirica R; Ford RJ; Donehower LA. 1999. Increased tumor cell proliferation in murine tumors with decreasing dosage of wild-type p53. Mol Carcinog 24(3):197-208. PubMed: 10204804MGI: J:101464
- Tyner SD; Venkatachalam S; Choi J; Jones S; Ghebranious N; Igelmann H; Lu X; Soron G; Cooper B; Brayton C; Hee Park S; Thompson T; Karsenty G; Bradley A; Donehower LA. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature 415(6867):45-53. PubMed: 11780111MGI: J:73757
- Uberti D; Piccioni L; Cadei M; Grigolato P; Rotter V; Memo M. 2001. p53 is dispensable for apoptosis but controls neurogenesis of mouse dentate gyrus cells following gamma-irradiation. Brain Res Mol Brain Res 93(1):81-9. PubMed: 11532341MGI: J:109332
- Uberti D; Schwartz D; Almog N; Goldfinger N; Harmelin A; Memo M; Rotter V. 1999. Epithelial cells of different organs exhibit distinct patterns of p53-dependent and p53-independent apoptosis following DNA insult. Exp Cell Res 252(1):123-33. PubMed: 10502405MGI: J:115353
- Ueki Y; Karl MO; Sudar S; Pollak J; Taylor RJ; Loeffler K; Wilken MS; Reardon S; Reh TA. 2012. P53 is required for the developmental restriction in Muller glial proliferation in mouse retina. Glia 60(10):1579-89. PubMed: 22777914MGI: J:186483
- Umesako S; Fujisawa K; Iiga S; Mori N; Takahashi M; Hong DP; Song CW; Haga S; Imai S; Niwa O; Okumoto M. 2005. Atm heterozygous deficiency enhances development of mammary carcinomas in p53 heterozygous knockout mice. Breast Cancer Res 7(1):R164-70. PubMed: 15642165MGI: J:96285
- Umesako S; Iiga S; Takahashi M; Imura K; Mori N; Hong DP; Song CW; Niwa O; Okumoto M. 2007. Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice. J Radiat Res (Tokyo) 48(2):143-52. PubMed: 17327688MGI: J:122711
- Uo T; Kinoshita Y; Morrison RS. 2007. Apoptotic actions of p53 require transcriptional activation of PUMA and do not involve a direct mitochondrial/cytoplasmic site of action in postnatal cortical neurons. J Neurosci 27(45):12198-210. PubMed: 17989286MGI: J:127443
- Uren AG; Kool J; Matentzoglu K; de Ridder J; Mattison J; van Uitert M; Lagcher W; Sie D; Tanger E; Cox T; Reinders M; Hubbard TJ; Rogers J; Jonkers J; Wessels L; Adams DJ; van Lohuizen M; Berns A. 2008. Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks. Cell 133(4):727-41. PubMed: 18485879MGI: J:136338
- Vaillant F; Blyth K; Andrew L; Neil JC; Cameron ER. 2002. Enforced Expression of Runx2 Perturbs T Cell Development at a Stage Coincident with beta-Selection. J Immunol 169(6):2866-74. PubMed: 12218099MGI: J:79075
- Van Batavia J; Yamany T; Molotkov A; Dan H; Mansukhani M; Batourina E; Schneider K; Oyon D; Dunlop M; Wu XR; Cordon-Cardo C; Mendelsohn C. 2014. Bladder cancers arise from distinct urothelial sub-populations. Nat Cell Biol 16(10):982-91, 1-5. PubMed: 25218638MGI: J:217711
- Vanasse GJ; Halbrook J; Thomas S; Burgess A; Hoekstra MF; Disteche CM; Willerford DM. 1999. Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase. J Clin Invest 103(12):1669-75. PubMed: 10377173MGI: J:119609
- Vasseur S; Afzal S; Tomasini R; Guillaumond F; Tardivel-Lacombe J; Mak TW; Iovanna JL. 2012. Consequences of DJ-1 upregulation following p53 loss and cell transformation. Oncogene 31(5):664-70. PubMed: 21725356MGI: J:181070
- Venkatachalam S; Shi YP; Jones SN; Vogel H; Bradley A; Pinkel D ; Donehower LA. 1998. Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation. EMBO J 17(16):4657-67. PubMed: 9707425MGI: J:49422
- Venkatachalam S; Tyner SD; Pickering CR; Boley S; Recio L; French JE; Donehower LA. 2001. Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing. Toxicol Pathol 29 Suppl:147-54. PubMed: 11695551MGI: J:73022
- Vogel KS; Klesse LJ; Velasco-Miguel S; Meyers K; Rushing EJ; Parada LF. 1999. Mouse tumor model for neurofibromatosis type 1. Science 286(5447):2176-9. PubMed: 10591653MGI: J:58877
- Vooijs M; te Riele H; van der Valk M; Berns A. 2002. Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells. Oncogene 21(30):4635-45. PubMed: 12096340MGI: J:77982
- Wang B; Ohyama H; Haginoya K; Odaka T; Itsukaichi H; Yukawa O; Yamada T; Hayata I. 2000. Adaptive response in embryogenesis. III. Relationship to radiation-induced apoptosis and Trp53 gene status. Radiat Res 154(3):277-82. PubMed: 10956433MGI: J:64384
- Wang C; Bogue MA; Roth DB; Meek K. 1997. Normal junctional diversification of immune receptors in p53-deficient mice. J Immunol 159(2):757-62. PubMed: 9218592MGI: J:110601
- Wang RH; Sengupta K; Li C; Kim HS; Cao L; Xiao C; Kim S; Xu X; Zheng Y; Chilton B; Jia R; Zheng ZM; Appella E; Wang XW; Ried T; Deng CX. 2008. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell 14(4):312-23. PubMed: 18835033MGI: J:140089
- Wang RH; Zheng Y; Kim HS; Xu X; Cao L; Luhasen T; Lee MH; Xiao C; Vassilopoulos A; Chen W; Gardner K; Man YG; Hung MC; Finkel T; Deng CX. 2008. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell 32(1):11-20. PubMed: 18851829MGI: J:141108
- Wang WL; Li Q; Xu J; Cvekl A. 2010. Lens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis. Mol Biol Cell 21(14):2453-68. PubMed: 20484573MGI: J:165054
- Wang X; Wang RH; Li W; Xu X; Hollander MC; Fornace AJ Jr; Deng CX. 2004. Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem 279(28):29606-14. PubMed: 15123655MGI: J:91673
- Wang XJ; Greenhalgh DA; Donehower LA; Roop DR. 2000. Cooperation between Ha-ras and fos or transforming growth factor alpha overcomes a paradoxic tumor-inhibitory effect of p53 loss in transgenic mouse epidermis Mol Carcinog 29(2):67-75. PubMed: 11074603MGI: J:66206
- Ward IM; Difilippantonio S; Minn K; Mueller MD; Molina JR; Yu X; Frisk CS; Ried T; Nussenzweig A; Chen J. 2005. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol 25(22):10079-86. PubMed: 16260621MGI: J:102355
- Warr MR; Binnewies M; Flach J; Reynaud D; Garg T; Malhotra R; Debnath J; Passegue E. 2013. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 494(7437):323-7. PubMed: 23389440MGI: J:194535
- Weaver Z; Montagna C; Xu X; Howard T; Gadina M; Brodie SG; Deng CX; Ried T. 2002. Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer. Oncogene 21(33):5097-107. PubMed: 12140760MGI: J:77948
- Wei M; Wanibuchi H; Morimura K; Salim EI; Moku M; Doi K; Mitsuhashi M; Masuda C; Shen J; Kinoshita A; Fukushima S. 2004. Lack of preventive efficacy of FK228, a histone deacetylase inhibitor, against N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in p53+/- and p53+/+ mice. Anticancer Res 24(2B):785-90. PubMed: 15161027MGI: J:90807
- Weiss WA; Aldape K; Mohapatra G; Feuerstein BG; Bishop JM. 1997. Targeted expression of MYCN causes neuroblastoma in transgenic mice. EMBO J 16(11):2985-95. PubMed: 9214616MGI: J:41126
- Weiss WA; Burns MJ; Hackett C; Aldape K; Hill JR; Kuriyama H; Kuriyama N; Milshteyn N; Roberts T; Wendland MF; DePinho R; Israel MA. 2003. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res 63(7):1589-95. PubMed: 12670909MGI: J:82649
- Welford SM; Bedogni B; Gradin K; Poellinger L; Broome Powell M; Giaccia AJ. 2006. HIF1alpha delays premature senescence through the activation of MIF. Genes Dev 20(24):3366-71. PubMed: 17142669MGI: J:116762
- Wikonkal NM; Remenyik E; Knezevic D; Zhang W; Liu M; Zhao H; Berton TR; Johnson DG; Brash DE. 2003. Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice. Nat Cell Biol 5(7):655-60. PubMed: 12833065MGI: J:84051
- Wilhelm MT; Rufini A; Wetzel MK; Tsuchihara K; Inoue S; Tomasini R; Itie-Youten A; Wakeham A; Arsenian-Henriksson M; Melino G; Kaplan DR; Miller FD; Mak TW. 2010. Isoform-specific p73 knockout mice reveal a novel role for {Delta}Np73 in the DNA damage response pathway. Genes Dev 24(6):549-60. PubMed: 20194434MGI: J:157905
- Wittschieben JP; Patil V; Glushets V; Robinson LJ; Kusewitt DF; Wood RD. 2010. Loss of DNA polymerase zeta enhances spontaneous tumorigenesis. Cancer Res 70(7):2770-8. PubMed: 20215524MGI: J:158922
- Wittschieben JP; Reshmi SC; Gollin SM; Wood RD. 2006. Loss of DNA polymerase zeta causes chromosomal instability in mammalian cells. Cancer Res 66(1):134-42. PubMed: 16397225MGI: J:105028
- Wolyniec K; Shortt J; de Stanchina E; Levav-Cohen Y; Alsheich-Bartok O; Louria-Hayon I; Corneille V; Kumar B; Woods SJ; Opat S; Johnstone RW; Scott CL; Segal D; Pandolfi PP; Fox S; Strasser A; Jiang YH; Lowe SW; Haupt S; Haupt Y. 2012. E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. Blood 120(4):822-32. PubMed: 22689861MGI: J:189091
- Woo Y; Wright SM; Maas SA; Alley TL; Caddle LB; Kamdar S; Affourtit J; Foreman O; Akeson EC; Shaffer D; Bronson RT; Morse HC 3rd; Roopenian D; Mills KD. 2007. The nonhomologous end joining factor Artemis suppresses multi-tissue tumor formation and prevents loss of heterozygosity. Oncogene 26(41):6010-20. PubMed: 17384673MGI: J:130286
- Wright MH; Robles AI; Herschkowitz JI; Hollingshead MG; Anver MR; Perou CM; Varticovski L. 2008. Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1. Mol Cancer 7:29. PubMed: 18394172MGI: J:206998
- Wright SM; Woo YH; Alley TL; Shirley BJ; Akeson EC; Snow KJ; Maas SA; Elwell RL; Foreman O; Mills KD. 2009. Complex oncogenic translocations with gene amplification are initiated by specific DNA breaks in lymphocytes. Cancer Res 69(10):4454-60. PubMed: 19435904MGI: J:148474
- Xiang H; Hochman DW; Saya H; Fujiwara T; Schwartzkroin PA; Morrison RS. 1996. Evidence for p53-mediated modulation of neuronal viability. J Neurosci 16(21):6753-65. PubMed: 8824316MGI: J:36059
- Xiao C; Kim HS; Lahusen T; Wang RH; Xu X; Gavrilova O; Jou W; Gius D; Deng CX. 2010. SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem 285(47):36776-84. PubMed: 20847051MGI: J:167023
- Xie L; Duncan MB; Pahler J; Sugimoto H; Martino M; Lively J; Mundel T; Soubasakos M; Rubin K; Takeda T; Inoue M; Lawler J; Hynes RO; Hanahan D; Kalluri R. 2011. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A 108(24):9939-44. PubMed: 21622854MGI: J:173322
- Xu G; Vogel KS; McMahan CA; Herbert DC; Walter CA. 2010. BAX and tumor suppressor TRP53 are important in regulating mutagenesis in spermatogenic cells in mice. Biol Reprod 83(6):979-87. PubMed: 20739667MGI: J:168357
- Xu X; Aprelikova O; Moens P; Deng CX; Furth PA. 2003. Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Development 130(9):2001-12. PubMed: 12642502MGI: J:82308
- Xu X; Qiao W; Linke SP; Cao L; Li WM; Furth PA; Harris CC; Deng CX. 2001. Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet 28(3):266-71. PubMed: 11431698MGI: J:70271
- Xu X; Wagner KU; Larson D; Weaver Z; Li C; Ried T; Hennighausen L ; Wynshaw-Boris A ; Deng CX. 1999. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation [see comments] Nat Genet 22(1):37-43. PubMed: 10319859MGI: J:54533
- Yamamoto M; Tsukamoto T; Sakai H; Shirai N; Ohgaki H; Furihata C; Donehower LA; Yoshida K; Tatematsu M. 2000. p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis Carcinogenesis 21(10):1891-7. PubMed: 11023548MGI: J:65239
- Yamanaka Y; Heike T; Kumada T; Shibata M; Takaoka Y; Kitano A; Shiraishi K; Kato T; Nagato M; Okawa K; Furushima K; Nakao K; Nakamura Y; Taketo MM; Aizawa S; Nakahata T. 2008. Loss of Borealin/DasraB leads to defective cell proliferation, p53 accumulation and early embryonic lethality. Mech Dev 125(5-6):441-50. PubMed: 18337066MGI: J:135988
- Yan CT; Kaushal D; Murphy M; Zhang Y; Datta A; Chen C; Monroe B; Mostoslavsky G; Coakley K; Gao Y; Mills KD; Fazeli AP; Tepsuporn S; Hall G; Mulligan R; Fox E; Bronson R; De Girolami U; Lee C; Alt FW. 2006. XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A 103(19):7378-83. PubMed: 16670198MGI: J:109585
- Yin L; Ghebranious N; Chakraborty S; Sheehan CE; Ilic Z; Sell S. 1998. Control of mouse hepatocyte proliferation and ploidy by p53 and p53ser246 mutation in vivo. Hepatology 27(1):73-80. PubMed: 9425920MGI: J:90869
- Yokoyama A; Ficara F; Murphy MJ; Meisel C; Naresh A; Kitabayashi I; Cleary ML. 2011. Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways. J Cell Sci 124(Pt 13):2208-19. PubMed: 21670200MGI: J:183048
- Yoshikai Y; Sato T; Morita S; Kohara Y; Takagi R; Mishima Y; Kominami R. 2008. Effect of Bcl11b genotypes and gamma-radiation on the development of mouse thymic lymphomas. Biochem Biophys Res Commun 373(2):282-5. PubMed: 18558082MGI: J:137956
- Yoshizuka N; Lai M; Liao R; Cook R; Xiao C; Han J; Sun P. 2012. PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway. Mol Cancer Res 10(6):810-20. PubMed: 22665523MGI: J:205386
- Youssef AF; Borellini F; Jacobson-Kram D; Fort FL. 2001. Analysis for loss of heterozygosity (LOH) of p53 allele in tumors derived from p53+/- and CD-1 mice following repeated subcutaneous injections of solutions containing antioxidants. Environ Mol Mutagen 37(1):27-30. PubMed: 11170239MGI: J:67508
- Yue HH; Diehl GE; Winoto A. 2005. Loss of TRAIL-R does not affect thymic or intestinal tumor development in p53 and adenomatous polyposis coli mutant mice. Cell Death Differ 12(1):94-7. PubMed: 15514675MGI: J:94118
- Zaidi AU; D'Sa-Eipper C; Brenner J; Kuida K; Zheng TS; Flavell RA; Rakic P; Roth KA. 2001. Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J Neurosci 21(1):169-75. PubMed: 11150333MGI: J:66953
- Zerafa N; Westwood JA; Cretney E; Mitchell S; Waring P; Iezzi M; Smyth MJ. 2005. Cutting edge: TRAIL deficiency accelerates hematological malignancies. J Immunol 175(9):5586-90. PubMed: 16237043MGI: J:103779
- Zhang H; Cicchetti G; Onda H; Koon HB; Asrican K; Bajraszewski N; Vazquez F; Carpenter CL; Kwiatkowski DJ. 2003. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest 112(8):1223-33. PubMed: 14561707MGI: J:162300
- Zhang QS; Eaton L; Snyder ER; Houghtaling S; Mitchell JB; Finegold M; Van Waes C; Grompe M. 2008. Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Cancer Res 68(5):1601-8. PubMed: 18316625MGI: J:132758
- Zhang QS; Tang W; Deater M; Phan N; Marcogliese AN; Li H; Al-Dhalimy M; Major A; Olson S; Monnat RJ Jr; Grompe M. 2016. Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice. Blood 128(24):2774-2784. PubMed: 27756748MGI: J:238747
- Zhang Z; Christin JR; Wang C; Ge K; Oktay MH; Guo W. 2016. Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation. Cell Rep 16(12):3146-56. PubMed: 27653681MGI: J:239126
- Zhang Z; Liu Q; Lantry LE; Wang Y; Kelloff GJ; Anderson MW; Wiseman RW; Lubet RA; You M. 2000. A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin. Cancer Res 60(4):901-7. PubMed: 10706103MGI: J:61217
- Zheng SJ; Lamhamedi-Cherradi SE; Wang P; Xu L; Chen YH. 2005. Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function. Diabetes 54(5):1423-8. PubMed: 15855329MGI: J:105195
- Zhou T; Hasty P; Walter CA; Bishop AJ; Scott LM; Rebel VI. 2013. Myelodysplastic syndrome: an inability to appropriately respond to damaged DNA? Exp Hematol 41(8):665-74. PubMed: 23643835MGI: J:215438
- Zhou XZ; Huang P; Shi R; Lee TH; Lu G; Zhang Z; Bronson R; Lu KP. 2011. The telomerase inhibitor PinX1 is a major haploinsufficient tumor suppressor essential for chromosome stability in mice. J Clin Invest 121(4):1266-82. PubMed: 21436583MGI: J:171997
- Zhu C; Mills KD; Ferguson DO; Lee C; Manis J; Fleming J; Gao Y; Morton CC; Alt FW. 2002. Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations. Cell 109(7):811-21. PubMed: 12110179MGI: J:77972
- Zhu J; Nguyen MT; Nakamura E; Yang J; Mackem S. 2012. Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway. Genesis 50(2):102-11. PubMed: 21913308MGI: J:187873
- Zhu M; Yi M; Kim CH; Deng C; Li Y; Medina D; Stephens RM; Green JE. 2011. Integrated miRNA and mRNA expression profiling of mouse mammary tumor models identifies miRNA signatures associated with mammary tumor lineage. Genome Biol 12(8):R77. PubMed: 21846369MGI: J:216041
- di Masi A; Antoccia A; Dimauro I; Argentino-Storino A; Mosiello A; Mango R; Novelli G; Tanzarella C. 2006. Gene expression and apoptosis induction in p53-heterozygous irradiated mice. Mutat Res 594(1-2):49-62. PubMed: 16169021MGI: J:106402
- van Meyel DJ; Sanchez-Sweatman OH; Kerkvliet N; Stitt L; Ramsay DA; Khokha R; Chambers AF; Cairncross JG. 1998. Genetic background influences timing, morphology and dissemination of lymphomas in p53-deficient mice. Int J Oncol 13(5):917-22. PubMed: 9772279MGI: J:51144
- van Vlijmen BJ; Gerritsen G; Franken AL; Boesten LS; Kockx MM; Gijbels MJ; Vierboom MP; van Eck M; van De Water B; van Berkel TJ; Havekes LM. 2001. Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE*3-Leiden transgenic mice. Circ Res 88(8):780-6. PubMed: 11325869MGI: J:133095
- van de Vrugt HJ; Eaton L; Hanlon Newell A; Al-Dhalimy M; Liskay RM; Olson SB; Grompe M. 2009. Embryonic lethality after combined inactivation of Fancd2 and Mlh1 in mice. Cancer Res 69(24):9431-8. PubMed: 19934329MGI: J:155534
- van der Weyden L; Adams DJ. 2013. Cancer of mice and men: old twists and new tails. J Pathol 230(1):4-16. PubMed: 23436574MGI: J:196071
Additional - Tg(LGB-cre)74Acl related
- Akhtar N; Marlow R; Lambert E; Schatzmann F; Lowe ET; Cheung J; Katz E; Li W; Wu C; Dedhar S; Naylor MJ; Streuli CH. 2009. Molecular dissection of integrin signalling proteins in the control of mammary epithelial development and differentiation. Development 136(6):1019-27. PubMed: 19211680MGI: J:146635
- Akhtar N; Streuli CH. 2013. An integrin-ILK-microtubule network orients cell polarity and lumen formation in glandular epithelium. Nat Cell Biol 15(1):17-27. PubMed: 23263281MGI: J:195230
- Baxter FO; Came PJ; Abell K; Kedjouar B; Huth M; Rajewsky K; Pasparakis M; Watson CJ. 2006. IKK{beta}/2 induces TWEAK and apoptosis in mammary epithelial cells. Development 133(17):3485-94. PubMed: 16887827MGI: J:112268
- Chapman RS; Lourenco PC; Tonner E; Flint DJ; Selbert S; Takeda K; Akira S; Clarke AR; Watson CJ. 1999. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev 13(19):2604-16. PubMed: 10521404MGI: J:58106
- Chester N; Babbe H; Pinkas J; Manning C; Leder P. 2006. Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol 26(17):6713-26. PubMed: 16914751MGI: J:112115
- Daly CS; Shaw P; Ordonez LD; Williams GT; Quist J; Grigoriadis A; Van Es JH; Clevers H; Clarke AR; Reed KR. 2017. Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium. Oncogene 36(13):1793-1803. PubMed: 27694902MGI: J:241092
- Davis KR; Giesy SL; Long Q; Krumm CS; Harvatine KJ; Boisclair YR. 2016. XBP1 Regulates the Biosynthetic Capacity of the Mammary Gland During Lactation by Controlling Epithelial Expansion and Endoplasmic Reticulum Formation. Endocrinology 157(1):417-28. PubMed: 26562262MGI: J:233630
- Di-Cicco A; Petit V; Chiche A; Bresson L; Romagnoli M; Orian-Rousseau V; Vivanco Md; Medina D; Faraldo MM; Glukhova MA; Deugnier MA. 2015. Paracrine Met signaling triggers epithelial-mesenchymal transition in mammary luminal progenitors, affecting their fate. Elife 4:. PubMed: 26165517MGI: J:225984
- Farrell AS; Pelz C; Wang X; Daniel CJ; Wang Z; Su Y; Janghorban M; Zhang X; Morgan C; Impey S; Sears RC. 2013. Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis. Mol Cell Biol 33(15):2930-49. PubMed: 23716601MGI: J:204572
- Forys JT; Kuzmicki CE; Saporita AJ; Winkeler CL; Maggi LB Jr; Weber JD. 2014. ARF and p53 coordinate tumor suppression of an oncogenic IFN-beta-STAT1-ISG15 signaling axis. Cell Rep 7(2):514-26. PubMed: 24726362MGI: J:211814
- Francis JC; Melchor L; Campbell J; Kendrick H; Wei W; Armisen-Garrido J; Assiotis I; Chen L; Kozarewa I; Fenwick K; Swain A; Smalley MJ; Lord CJ; Ashworth A. 2015. Whole-exome DNA sequence analysis of Brca2- and Trp53-deficient mouse mammary gland tumours. J Pathol 236(2):186-200. PubMed: 25692405MGI: J:221054
- Gallagher RC; Hay T; Meniel V; Naughton C; Anderson TJ; Shibata H; Ito M; Clevers H; Noda T; Sansom OJ; Mason JO; Clarke AR. 2002. Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene 21(42):6446-57. PubMed: 12226748MGI: J:79068
- Hay T; Matthews JR; Pietzka L; Lau A; Cranston A; Nygren AO; Douglas-Jones A; Smith GC; Martin NM; O'Connor M; Clarke AR. 2009. Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res 69(9):3850-5. PubMed: 19383921MGI: J:148266
- Hughes K; Wickenden JA; Allen JE; Watson CJ. 2012. Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol 227(1):106-17. PubMed: 22081431MGI: J:183317
- Karim SA; Creedon H; Patel H; Carragher NO; Morton JP; Muller WJ; Evans TR; Gusterson B; Sansom OJ; Brunton VG. 2013. Dasatinib inhibits mammary tumour development in a genetically engineered mouse model. J Pathol 230(4):430-40. PubMed: 23616343MGI: J:198826
- Kritikou EA; Sharkey A; Abell K; Came PJ; Anderson E; Clarkson RW; Watson CJ. 2003. A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development 130(15):3459-68. PubMed: 12810593MGI: J:83804
- Li M; Chen Q; Yu X. 2017. Chemopreventive Effects of ROS Targeting in a Murine Model of BRCA1-Deficient Breast Cancer. Cancer Res 77(2):448-458. PubMed: 27815389MGI: J:238429
- Li W; Ferguson BJ; Khaled WT; Tevendale M; Stingl J; Poli V; Rich T; Salomoni P; Watson CJ. 2009. PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool. Proc Natl Acad Sci U S A 106(12):4725-30. PubMed: 19261859MGI: J:147092
- Mamillapalli R; VanHouten J; Dann P; Bikle D; Chang W; Brown E; Wysolmerski J. 2013. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology 154(9):3031-42. PubMed: 23782944MGI: J:202283
- Matthews JR; Clarke AR. 2005. p53 mediates a default programme of mammary gland involution in the absence of STAT3. Oncogene 24(19):3083-90. PubMed: 15735683MGI: J:98296
- McCarthy A; Lord CJ; Savage K; Grigoriadis A; Smith DP; Weigelt B; Reis-Filho JS; Ashworth A. 2009. Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J Pathol 219(3):306-16. PubMed: 19681070MGI: J:153735
- Melchor L; Molyneux G; Mackay A; Magnay FA; Atienza M; Kendrick H; Nava-Rodrigues D; Lopez-Garcia MA; Milanezi F; Greenow K; Robertson D; Palacios J; Reis-Filho JS; Smalley MJ. 2014. Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models. J Pathol 233(2):124-37. PubMed: 24615332MGI: J:210989
- Meniel V; Hay T; Douglas-Jones A; Sansom OJ; Clarke AR. 2005. Mutations in Apc and p53 synergize to promote mammary neoplasia. Cancer Res 65(2):410-6. PubMed: 15695381MGI: J:96023
- Molyneux G; Geyer FC; Magnay FA; McCarthy A; Kendrick H; Natrajan R; Mackay A; Grigoriadis A; Tutt A; Ashworth A; Reis-Filho JS; Smalley MJ. 2010. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 7(3):403-17. PubMed: 20804975MGI: J:164435
- Naylor MJ; Li N; Cheung J; Lowe ET; Lambert E; Marlow R; Wang P; Schatzmann F; Wintermantel T; Schuetz G; Clarke AR; Mueller U; Hynes NE; Streuli CH. 2005. Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. J Cell Biol 171(4):717-28. PubMed: 16301336MGI: J:104534
- Neville MC; Webb P; Ramanathan P; Mannino MP; Pecorini C; Monks J; Anderson SM; MacLean P. 2013. The insulin receptor plays an important role in secretory differentiation in the mammary gland. Am J Physiol Endocrinol Metab 305(9):E1103-14. PubMed: 23982156MGI: J:203934
- Oliver CH; Khaled WT; Frend H; Nichols J; Watson CJ. 2012. The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev 26(10):1086-97. PubMed: 22588720MGI: J:184505
- Rudolph MC; Monks J; Burns V; Phistry M; Marians R; Foote MR; Bauman DE; Anderson SM; Neville MC. 2010. Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium. Am J Physiol Endocrinol Metab 299(6):E918-27. PubMed: 20739508MGI: J:170224
- Sargeant TJ; Lloyd-Lewis B; Resemann HK; Ramos-Montoya A; Skepper J; Watson CJ. 2014. Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. Nat Cell Biol 16(11):1057-68. PubMed: 25283994MGI: J:217705
- Selbert S; Bentley DJ; Melton DW; Rannie D; Lourenco P; Watson CJ; Clarke AR. 1998. Efficient BLG-Cre mediated gene deletion in the mammary gland. Transgenic Res 7(5):387-96. PubMed: 9859227MGI: J:70554
- Stewart MK; Plante I; Bechberger JF; Naus CC; Laird DW. 2014. Mammary gland specific knockdown of the physiological surge in Cx26 during lactation retains normal mammary gland development and function. PLoS One 9(7):e101546. PubMed: 24988191MGI: J:218935
- VanHouten JN; Dann P; Stewart AF; Watson CJ; Pollak M; Karaplis AC; Wysolmerski JJ. 2003. Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. (Correction J Clin Invest 2004:113(3):492)n J Clin Invest 112(9):1429-36. PubMed: 14597768MGI: J:86536
- Wakefield A; Soukupova J; Montagne A; Ranger J; French R; Muller WJ; Clarkson RW. 2013. Bcl3 selectively promotes metastasis of ERBB2-driven mammary tumors. Cancer Res 73(2):745-55. PubMed: 23149915MGI: J:194106
- Yazinski SA; Westcott PM; Ong K; Pinkas J; Peters RM; Weiss RS. 2009. Dual inactivation of Hus1 and p53 in the mouse mammary gland results in accumulation of damaged cells and impaired tissue regeneration. Proc Natl Acad Sci U S A 106(50):21282-7. PubMed: 19918068MGI: J:155573
- Zhang Z; Christin JR; Wang C; Ge K; Oktay MH; Guo W. 2016. Mammary-Stem-Cell-Based Somatic Mouse Models Reveal Breast Cancer Drivers Causing Cell Fate Dysregulation. Cell Rep 16(12):3146-56. PubMed: 27653681MGI: J:239126