These mice exhibit a degree of toe fusion that is similar to the phenotype of Hoxa13Hd mice.
Read More +Genetic Background | Generation |
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|
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Hdlk | hypodactyly like |
Heterozygotes have one fused digit on the hind feet, absent terminal phalanx of the first or first and second digit of the hind feet, and normal fore feet. Homozygotes lack the most anterior digit of both fore feet and hind feet, and are sterile
The Hdlk mutation arose spontaneously in a transgenic stock that had 129S1/Sv, 129X1/SvJ, and ICR in its genetic background and had been sibling inbred for over 10 generations at The Jackson Laboratory when the Hdlk mutation arose. The parental transgenic stock was maintained segregating for the X-linked transgenic insertion and this was selected out of the mutant subline (stock# 010982) through selective sibling inbreeding. In 2010 sperm were cryopreserved from heterozygous males at generation F17, and the assigned oocyte donor for cryorecovery of this bankstock is C57BL/6J.
When using the Hypodactyly like mouse strain in a publication, please cite the originating article(s) and include JAX stock #012596 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or wildtype for Hdlk |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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