C57BL/6J x STOCK Hdlk/GrsrJ

Stock number: 012596
Product name: Hypodactyly like
Research areas: Developmental Biology Research

Description

These mice exhibit a degree of toe fusion that is similar to the phenotype of Hoxa13^Hd mice.

Detailed description

Heterozygotes have one fused digit on the hind feet, absent terminal phalanx of the first or first and second digit of the hind feet, and normal fore feet. Homozygotes lack the most anterior digit of both fore feet and hind feet, and are sterile

Development

The Hdlk mutation arose spontaneously in a transgenic stock that had 129S1/Sv, 129X1/SvJ, and ICR in its genetic background and had been sibling inbred for over 10 generations at The Jackson Laboratory when the Hdlk mutation arose. The parental transgenic stock was maintained segregating for the X-linked transgenic insertion and this was selected out of the mutant subline (stock# 010982) through selective sibling inbreeding. In 2010 sperm were cryopreserved from heterozygous males at generation F17, and the assigned oocyte donor for cryorecovery of this bankstock is C57BL/6J.

Allele

Symbol: Hdlk
Name: hypodactyly like
MGI accession ID: MGI:4367718
Generation method: Spontaneous
Marker symbol: Hdlk
Marker name: hypodactyly like
Chromosome: 6
Strain of origin: Not Specified
Molecular note: This spontaneous mutation was identified at The Jackson Laboratory.